Pancuronium is a Medicine belongs to Neuromuscular blocker group whose information about Brand can be referenced from   Book : Martindale    Page : 2036   Edition : 38  

  ►   Brandname : Panconium, Neocuron, Panuron, Pavulon
  ►  Strength : Injection with 2 mg/ml.  Injection with 1 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Martindale    Page : 2071   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Endotracheal intubation IV 50 100 micrograms/kg Injection Doses of neuromuscular blockers need to be carefully titrated for individual patients according to response, and may vary with the procedure, the other drugs given, and the state of the patient; monitoring of the degree of block is recommended in order to reduce the risk of overdosage. The maintenance doses are 10 to 20 micrograms/kg.
2 Patients who require assisted ventilation IV 60 micrograms/kg Injection Adult patients under intensive care who require assisted ventilation for conditions such as intractable status asthmaticus or tetanus may be given drug in dose given above every 1 to 1.5 hours or less frequently.

Ref :-  Book : Martindale    Page : 2035   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Endotracheal intubation 30 40 micrograms/kg

Ref :- Book : Martindale    Page : 2035   Edition : 38  
Precaution :- If a Patient is using 'Pancuronium' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

►  Side Effect : Tachycardia, Hypertension, Excessive salivation in some patients
Ref :-   Book : Martindale    Page : 2071   Edition : 37.  

►  Drug Interaction : Drug interaction of Pancuronium is with anticholinesterases,  Lidocaine , Procainamide , Quinidine , Verapamil , Clindamycin , Lincomycin, Colistin, Polymyxin B, Carbamazapine , Phenytoin
Ref :-   Book : Martindale    Page : 2066,2071   Edition : 37.   Martindale    Page : 2031,2035   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Some drugs may influence neuromuscular transmission and thus interfere with the action of both competitive and depolarising neuromuscular blockers, resulting in potentiation or antagonism of neuromuscular block. Some interactions may be advantageous, such as the reversal of competitive neuromuscular block by anticholinesterases. In general, adverse interactions are potentially more serious in patients with impaired neuromuscular function. Lidocaine, procainamide, quinidine, and verapamil all have some neuromuscular blocking activity and may enhance the block produced by neuromuscular blockers. Large doses of lidocaine may reduce the release of acetylcholine and act directly on the muscle membrane. Quinidine has a curare-like action at the neuromuscular junction and depresses the muscle action potential. If given during recovery from neuromuscular block it can result in muscle weakness and apnoea and it should be avoided, if possible, in the immediate postoperative period. Some antibacterials in very high concentration can produce a muscle paralysis that may be additive to or synergistic with that produced by neuromuscular blockers. The neuromuscular block produced by antibacterials may be enhanced in patients with intracellular potassium deficiency, low plasma-calcium concentration, neuromuscular disease, or a tendency to a high plasma-antibacterial concentration, for example after large doses or in renal impairment.The interaction appears to be more important for competitive neuromuscular blockers. The antibacterials most commonly implicated are aminoglycosides, lincosamides, polymyxins, and, more rarely, tetracyclines.
Ref :-   Book : Martindale    Page : 2031,2035   Edition : 38.  

►  Contraindication : Renal impairment, Respiratory insufficiency or pulmonary disease
Ref :-   Book : Martindale    Page : 2066   Edition : 37.  
  ►  Mechanism of Action :   Competitive neuromuscular blockers act by competing with acetylcholine for receptors on the motor end-plate of the neuromuscular junction to produce blockade. The muscles that produce fine rapid movements such as those of the face are the first to be affected, followed by those of the limbs and torso; the last to be affected are those of the diaphragm. The paralysis is reversible with recovery occurring in reverse order.
Ref :-   Book : Martindale    Page : 2030   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal, Biliary
Ref :-   Book : Martindale    Page : 2071   Edition : 37.  

►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 2071   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : .