Pantoprazole is a Medicine belongs to Gastrointestinal drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1915   Edition : 37      Page :   Edition :   

  ►   Brandname : Pantop, Pantocid, Pantodac, Protium, Protonix, Pantocid-DSR, Somac, Pantozol, Pan, Pan 40, Pan D, Pan L, Pansec L, Pantakind, Pantakind DSR, Pantop 40, Pantop D
  ►  Strength : Delayed- release tablets with 20 Mg.  Delayed- release tablets with 40 Mg.  Suspension with 40 Mg.  Injection with 40 mg/vial. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV
Reference :-   Book : Goodman    Page : 1312   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gastro-oesophageal reflux disease Oral 20 80 mg Tablet o.d. Treatment is usually given for 4 weeks, increased to 8 weeks if necessary. Pantoprazole may be given i.v, as the sodium salt, over 2 to 15 minutes, either as a slow injection or a short-term infusion. The recommended dose is 40 mg daily.
2 Peptic ulcer disease Oral 40 80 mg Tablet o.d. Treatment is usually given for 2 to 4 weeks for duodenal ulceration, or 4 to 8 weeks for benign gastric ulceration. Pantoprazole may be given i.v, as the sodium salt, over 2 to 15 minutes, either as a slow injection or a short-term infusion. The recommended dose is 40 mg daily.
3 Eradication of H. pylori Oral 40 mg Tablet b.d. Pantoprazole may be combined with two antibacterials in a 1-week triple therapy regimen.
4 NSAIDS associated ulcer Oral / i.v 20 mg o.d. Patients who require prophylaxis for NSAID-associated ulceration.
5 Pathological hypersecretory states Oral / i.v For treatment of hypersecretory states such as the Zollinger-Ellison syndrome. The initial dose is 80 mg daily, adjusted as required. Doses of up to 240 mg daily have been used. Daily doses greater than 80 mg should be given in 2 divided doses. IV dose of 80 mg once or twice daily may be used for Zollinger-Ellison syndrome. Patients should be switched to oral therapy as soon as possible.

Ref :-  Book : Martindale    Page : 1875   Edition : 38   Martindale    Page : 1875-1876   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Eradication of H. pylori 1 mg/kg/day

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1293   Edition : 19  
Precaution :- If a Patient is using 'Pantoprazole' drug in  hypothyroidism  disease, then Please use with caution .

►  Side Effect : Headache, Diarrhea, Rashes, Anorexia, Gastrointestinal discomfort, Asthenia, Back pain, Pancreatitis, Hepatotoxicity, Interstitial nephritis, Possible interference with antiplatelet effects of clopidogrel, Possible increased risk of hip, wrist, and spine fracture, Hospital-acquired pneumonia, Enteric infections including clostridium difficile, Salmonella infection, Escherichia coli
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 818   Edition : 3.  

►  Drug Interaction : Drug interaction of Pantoprazole is with Clopidogrel
Ref :-   Book : Goodman    Page : 1312   Edition : 12.  


  ►    Mechanism of Drug Drug Interaction :  Pantoprazole is less likely to result in interaction with the anticlotting agent, clopidogrel; concurrent use of clopidogrel and PPIs (mainly pantoprazole) significantly reduced GI bleeding without increasing adverse cardiac events.
Ref :-   Book : Goodman    Page : 1312   Edition : 12.  


►  Contraindication : Therapy stopped if liver enzymes are elevated, Gastric malignancies
Ref :-   Book : Martindale    Page : 1870,1876   Edition : 38.  
  ►  Mechanism of Action :   The activated form of pantoprazole binds covalently with sulfhydryl groups of cysteines in the H+, K+-ATPase, irreversibly inactivating the pump molecule.
Ref :-   Book : Goodman    Page : 1311   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with same pathway.   Turmeric with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Inhibit potassium adenosine triphosphatase enzyme --- (Mahmmoud, Y. (2011). Curcumin is a lipid dependent inhibitor of the Na,K-ATPase that likely interacts at the protein-lipid Interface. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1808(1), pp.466-473. )
  • antiulcer property --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL --
  • http://www.sciencedirect.com/science/article/pii/S0005273610003366 .
  • http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor.  

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Basic & Clinical pharmacology    Page : 1086   Edition : 12.  

    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   1.9 hours.  
    Ref :-   Book : Basic & Clinical pharmacology    Page : 1086   Edition : 12.  

    ►    Peak Plasma Concentration :   Min value :-   2.5 hours,    Max value :-   4 hours.  
    Ref :-   Book : Basic & Clinical pharmacology    Page : 1086   Edition : 12.