Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Gastro-oesophageal reflux disease	Oral	20	80	mg	Tablet	o.d.	Treatment is usually given for 4 weeks, increased to 8 weeks if necessary. Pantoprazole may be given i.v, as the sodium salt, over 2 to 15 minutes, either as a slow injection or a short-term infusion. The recommended dose is 40 mg daily.
2	Peptic ulcer disease	Oral	40	80	mg	Tablet	o.d.	Treatment is usually given for 2 to 4 weeks for duodenal ulceration, or 4 to 8 weeks for benign gastric ulceration. Pantoprazole may be given i.v, as the sodium salt, over 2 to 15 minutes, either as a slow injection or a short-term infusion. The recommended dose is 40 mg daily.
3	Eradication of H. pylori	Oral	40		mg	Tablet	b.d.	Pantoprazole may be combined with two antibacterials in a 1-week triple therapy regimen.
4	NSAIDS associated ulcer	Oral / i.v	20		mg		o.d.	Patients who require prophylaxis for NSAID-associated ulceration.
5	Pathological hypersecretory states	Oral / i.v						For treatment of hypersecretory states such as the Zollinger-Ellison syndrome. The initial dose is 80 mg daily, adjusted as required. Doses of up to 240 mg daily have been used. Daily doses greater than 80 mg should be given in 2 divided doses. IV dose of 80 mg once or twice daily may be used for Zollinger-Ellison syndrome. Patients should be switched to oral therapy as soon as possible.

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Gastro-oesophageal reflux disease	Oral	20	80	mg	Tablet	o.d.	Treatment is usually given for 4 weeks, increased to 8 weeks if necessary. Pantoprazole may be given i.v, as the sodium salt, over 2 to 15 minutes, either as a slow injection or a short-term infusion. The recommended dose is 40 mg daily.
2	Peptic ulcer disease	Oral	40	80	mg	Tablet	o.d.	Treatment is usually given for 2 to 4 weeks for duodenal ulceration, or 4 to 8 weeks for benign gastric ulceration. Pantoprazole may be given i.v, as the sodium salt, over 2 to 15 minutes, either as a slow injection or a short-term infusion. The recommended dose is 40 mg daily.
3	Eradication of H. pylori	Oral	40		mg	Tablet	b.d.	Pantoprazole may be combined with two antibacterials in a 1-week triple therapy regimen.
4	NSAIDS associated ulcer	Oral / i.v	20		mg		o.d.	Patients who require prophylaxis for NSAID-associated ulceration.
5	Pathological hypersecretory states	Oral / i.v						For treatment of hypersecretory states such as the Zollinger-Ellison syndrome. The initial dose is 80 mg daily, adjusted as required. Doses of up to 240 mg daily have been used. Daily doses greater than 80 mg should be given in 2 divided doses. IV dose of 80 mg once or twice daily may be used for Zollinger-Ellison syndrome. Patients should be switched to oral therapy as soon as possible.

Ref :-  Book : Martindale    Page : 1875   Edition : 38   Martindale    Page : 1875-1876   Edition : 38  

Pediatric Dose

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1293   Edition : 19  

Precaution :- If a Patient is using 'Pantoprazole' drug in  hypothyroidism  disease, then Please use with caution .

►  Side Effect : Headache, Diarrhea, Rashes, Anorexia, Gastrointestinal discomfort, Asthenia, Back pain, Pancreatitis, Hepatotoxicity, Interstitial nephritis, Possible interference with antiplatelet effects of clopidogrel, Possible increased risk of hip, wrist, and spine fracture, Hospital-acquired pneumonia, Enteric infections including clostridium difficile, Salmonella infection, Escherichia coli
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 818   Edition : 3.  
►  Drug Interaction : Drug interaction of Pantoprazole is with Clopidogrel
Ref :-   Book : Goodman    Page : 1312   Edition : 12.  

Drug interaction

Drug Interaction : Drug interaction of Pantoprazole is with Clopidogrel

Book : Goodman    Page : 1312   Edition : 12.  

  ►    Mechanism of Drug Drug Interaction :  Pantoprazole is less likely to result in interaction with the anticlotting agent, clopidogrel; concurrent use of clopidogrel and PPIs (mainly pantoprazole) significantly reduced GI bleeding without increasing adverse cardiac events.
Ref :-   Book : Goodman    Page : 1312   Edition : 12.  

Mechanism of Drug

Mechanism of Drug Drug Interaction : Pantoprazole is less likely to result in interaction with the anticlotting agent, clopidogrel; concurrent use of clopidogrel and PPIs (mainly pantoprazole) significantly reduced GI bleeding without increasing adverse cardiac events.

Book : Goodman    Page : 1312   Edition : 12.  

►  Contraindication : Therapy stopped if liver enzymes are elevated, Gastric malignancies
Ref :-   Book : Martindale    Page : 1870,1876   Edition : 38.  

  ►  Mechanism of Action :   The activated form of pantoprazole binds covalently with sulfhydryl groups of cysteines in the H+, K+-ATPase, irreversibly inactivating the pump molecule.
Ref :-   Book : Goodman    Page : 1311   Edition : 12.  

►   Route of Elimination :   Renal
Ref :-   Book : Basic & Clinical pharmacology    Page : 1086   Edition : 12.  
►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   1.9 hours.  
Ref :-   Book : Basic & Clinical pharmacology    Page : 1086   Edition : 12.  
►    Peak Plasma Concentration :   Min value :-   2.5 hours,    Max value :-   4 hours.  
Ref :-   Book : Basic & Clinical pharmacology    Page : 1086   Edition : 12.