Pantoprazole is a Medicine belongs to Gastrointestinal drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1915   Edition : 37,    Page :   Edition : ,

  ►   Brandname :
Pantop,Pantocid,Pantodac,Protium,Protonix,Pantocid-DSR,Somac,Pantozol,Pan,Pan 40,Pan D,Pan L,Pansec L,Pantakind,Pantakind DSR,Pantop 40,Pantop D


  ►  Strength :
Delayed- release tablets with 20  Mg, Delayed- release tablets with 40  Mg, Suspension with 40  Mg, Injection with 40  mg/vial,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration :
Oral, IV,
Reference :-   Book : Goodman    Page : 1312   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gastro-oesophageal reflux disease Oral 20 80 mg Tablet o.d. Given for 4 weeks which may increased to 8 weeks if necessary. For maintenance therapy, treatment can be continued with 20 to 40 mg daily. Pantoprazole may be given i.v, as the sodium salt, over 2 to 15 minutes, either as a slow injection or a short-term infusion. The recommended dose is 40 mg daily.
2 Peptic ulcer disease Oral 40 80 mg Tablet Treatment is usually given for 2 to 4 weeks for duodenal ulceration, or 4 to 8 weeks for benign gastric ulceration. Pantoprazole may be given i.v, as the sodium salt, over 2 to 15 minutes, either as a slow injection or a short-term infusion. The recommended dose is 40 mg daily.
3 Eradication of H. pylori Oral 40 mg Tablet b.d. Pantoprazole may be combined with two antibacterials in a 1-week triple therapy regimen.
4 NSAIDS associated ulcer Oral / i.v 20 mg o.d. For it's prophylaxis.
5 Zollinger-ellison syndrome Oral / i.v 80 240 mg For treatment of pathological hypersecretory states such as the Zollinger-Ellison syndrome. Daily doses greater than 80 mg should be given in 2 divided doses. Pantoprazole may be given i.v, as the sodium salt, over 2 to 15 minutes, either as a slow injection or a short-term infusion. A dose of 80 mg once or twice daily may be used for Zollinger-Ellison syndrome; up to 240 mg daily may be given in divided doses. Patients should be switched to oral therapy as soon as possible.

Ref :-  Book : Martindale    Page : 1875   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antisecretory therapy Oral 40 mg
2 Eradication of H. pylori 1 mg/kg/day

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1293   Edition : 19,
Precaution :- If a Patient is using 'Pantoprazole' drug in  hypothyroidism  disease, then Please use with caution .

►  Side Effect :
headache, diarrhea, Rashes, anorexia, gastrointestinal discomfort, asthenia, back pain, Pancreatitis, hepatotoxicity, interstitial nephritis, possible interference with antiplatelet effects of clopidogrel, possible increased risk of hip, wrist, and spine fracture, hospital-acquired pneumonia, enteric infections including clostridium difficile, salmonella infection, Escherichia coli,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 818   Edition : 3,
►  Drug Interaction : Drug interaction of Pantoprazole is with
Clopidogrel ,
Ref :-   Book : Goodman    Page : 1312   Edition : 12,

  ►    Mechanism of Drug Drug Interaction : 
Pantoprazole is less likely to result in interaction with the anticlotting agent, clopidogrel; concurrent use of clopidogrel and PPIs (mainly pantoprazole) significantly reduced GI bleeding without increasing adverse cardiac events.,
Ref :-   Book : Goodman    Page : 1312   Edition : 12,

►  Contraindication :
therapy stopped if liver enzymes are elevated, Gastric malignancies,
Ref :-   Book : Martindale    Page : 1870,1876   Edition : 38,
  ►  Mechanism of Action :  
The activated form of pantoprazole binds covalently with sulfhydryl groups of cysteines in the H+, K+-ATPase, irreversibly inactivating the pump molecule.,
Ref :-   Book : Goodman    Page : 1311   Edition : 12,

Pathway of Dietry Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with same pathway, Turmeric with Another pathway,

  ►  Pathway with its reference as follows :-
  • Inhibit potassium adenosine triphosphatase enzyme --- (Mahmmoud, Y. (2011). Curcumin is a lipid dependent inhibitor of the Na,K-ATPase that likely interacts at the protein-lipid Interface. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1808(1), pp.466-473. )
  • antiulcer property --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

    •   ►  URL -- http://www.sciencedirect.com/science/article/pii/S0005273610003366, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions

    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

    •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :  
    Renal,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 1086   Edition : 12,

    ►    Plasma Half-life :      
    Min value :-   1 hours,    Max value :-   1.9 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 1086   Edition : 12,

    ►    Peak Plasma Concentration :  
    Min value :-   2.5 hours,    Max value :-   4 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 1086   Edition : 12,