Paracetamol is a Medicine belongs to Analgesics/Anti-inflammatory Drugs/Antipyretics group whose information about Brand can be referenced from   Book : Martindale    Page : 118   Edition : 38, Martindale    Page : 118   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Calpol,Acephen,Crocin,Abdine Cold Relief,Ultracet,Acenac P,Dynapar,Aceva SP,PCM,P U C,Dolo,Panadol,Zerodol P, Zerodol SP,P 250,P 125

  ►  Strength : Capsule with 325  mg, Capsule with 500  mg, Elixir with 80  mg/5mL, Elixir with 120  mg/5mL, Elixir with 160  mg/5mL, Elixir with 500  mg/15ml, Oral solution with 80  mg/1.66 ml, Oral solution with 100  mg/ml, Suppository with 80  mg, Suppository with 120  mg, Suppository with 125  mg, Suppository with 300  mg, Suppository with 325  mg, Suppository with 650  Mg, Injection with   , Tablet with 160  mg, Tablet with 325  mg, Tablet with 500  mg, Tablet with 650  mg, Chewable tablets with 80  mg, caplets with 160  mg, caplets with 500  mg, caplets with 650  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12th, Basic & Clinical pharmacology    Page : 656   Edition : 12, Martindale    Page : 115   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal, IV,
Reference :-   Book : Martindale    Page : 115   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Mild to moderate pain and for fever Oral 0.5 1 gm Tablet Given every 4 to 6 hours. Maximum oral dose is 4 gm daily. Rectal max. dose is above given dose up to 4 times daily.
2 Short-term treatment of moderate pain after surgery and of fever IV infusion 1 gm Injection Given to patients weighing over 50 kg; single doses of 1 g every 4 or more hours, to a maximum of 4 g daily.
3 Short-term treatment of moderate pain after surgery and of fever IV infusion Injection Given to patients weighing from 33 to 50 kg; single doses of 15 mg/kg every 4 or more hours, to a maximum of 60 mg/kg or 3 g daily (whichever is less).

Ref :-  Book : Martindale    Page : 115   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 For pain and fever 3 Month 1 year Oral 60 120 mg Oral solution
2 For pain and fever 1 Year 5 Year Oral 120 250 mg Oral solution
3 For pain and fever 6 Year 12 Year Oral 250 500 mg Oral solution
4 Moderate pain Below 10 kg IV infusion Injection
5 Moderate pain Between 10-33 kg IV infusion Injection
6 Moderate pain From 33-50 kg IV infusion Injection
7 For pain and fever Oral Oral solution
8 For pain and fever Oral Oral solution
9 For more severe symptoms 1 Month 3 Month Oral Oral solution
10 For more severe symptoms Above 3 Months Oral Oral solution
11 For pain and fever 1 Month 3 Month rectal 30 60 mg/kg Suppository
12 For pain and fever above 3 months rectal 30 to 40 90 mg/kg Suppository
13 For pain and fever 3 Month 1 Year rectal 60 125 mg Suppository
14 For pain and fever 1 Year 5 Year rectal 125 250 mg Suppository
15 For pain and fever 6 Year 12 Year rectal 250 500 mg Suppository

Ref :- Book : Martindale    Page : 115   Edition : 37,
►  Organ Affected Liver Disease – (Generates Toxic Metabolite)  

Precaution :- If a Patient is using 'Paracetamol' drug in  Acute Viral Hepatitis  disease, then Please hepatotoxic .

Precaution :- If a Patient is using 'Paracetamol' drug in ACUTE VIRAL HEPATITIS disease, then Please use with caution   if he ever suffered from ABDOMEN PAIN disease.
►  Side Effect : Adverse effects are rare and usually mild, although haematological reactions including thrombocytopenia,, leucopenia, pancytopenia, neutropenia, agranulocytosis have been reported, Skin rashes and other hypersensitivity reactions occur occasionally, injection-site reaction such as pain and burning sensation are common, application site reaction noted after rectal use, ,
Ref :-   Book : Martindale    Page : 115   Edition : 38,

►  Drug Interaction : Drug interaction of Paracetamol is with , ,  Probenecid , Cholestyramine , Metoclopramide ,
Ref :-   Book : Martindale    Page : 114,115   Edition : 37, Martindale    Page : 118   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The risk of paracetamol toxicity may be increased in patients receiving other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes. The absorption of paracetamol may be accelerated by drugs such as metoclopramide. Excretion may be affected and plasma concentrations altered when given with probenecid. Colestyramine reduces the absorption of paracetamol if given within 1 hour of paracetamol.,
Ref :-   Book : Martindale    Page : 118   Edition : 38,


►  Absolute Contraindication : Impaired kidney or liver function.  

►  Contraindication : larger doses should be avoided in patients with hepatic impairment, should be given with care to patients with impaired kidney or liver function, alcohol dependence, chronic malnutrition, or dehydration,
Ref :-   Book : Martindale    Page : 118   Edition : 38,
  ►  Mechanism of Action :   Paracetamol, a para-aminophenol derivative, has analgesic and antipyretic properties and weak antiinflammatory activity. It is poor COX inhibitor. It has been suggested that COX inhibition might be disproportionately pronounced in the brain, explaining its antipyretic efficacy.,
Ref :-   Book : Martindale    Page : 115   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tulsi with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antipyretic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- GLUCOSAMINE with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- BETANIN HCL with Increase the risk of bleeding,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 115   Edition : 37,


    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 115   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   10 min,    Max value :-   60 min,
    Ref :-   Book : Martindale    Page : 118   Edition : 38,