Pefloxacin is a Medicine belongs to FLUOROQUINOLONES group whose information about Brand can be referenced from   Book : Martindale    Page : 338   Edition : 38,

  ►   Brandname : Pelox,Proflox,Qucin

  ►  Strength : Capsule with nf  ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 935   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 341   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gonococcal urethritis Oral 800 mg A single dose given to men.
2 Acute uncomplicated cystitis Oral 800 mg A single dose given to women.

Ref :-  Book : Martindale    Page : 341   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Gastrointestinal upset, allergic reaction, rash, pruritus, arthralgia, pruritus, photosensitivity, anaphylaxis, diarrhea, blue-gray skin pigmentation, Dizziness, headache, Confusion, convulsion, rupture of tendons, corneal precipitates, destructive arthropathy,
Ref :-   Book : Martindale    Page : 263,338   Edition : 38,

►  Drug Interaction : Drug interaction of Pefloxacin is with Sucralfate , Probenecid , Tiagabine, Oxcarbazepine , Zonisamide , Iron , Sildenafil ,
Ref :-   Book : Martindale    Page : 1151,1158,1161   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Sucralfate reduces gastrointestinal absorption of pefloxacin, and probably other quinolones. Antacids may adsorb drugs in gastrointestinal tract, thus decreasing gastrointestinal absorption of pefloxacin. Iron binds with quinolones in gastrointestinal tract, thereby reducing absorption of pefloxacin and other quinolones. The excretion of pefloxacin or related drugs is reduced and plasma concentrations may be increased by probenecid. Cations such as aluminium, calcium, magnesium, reduce the absorption of oral pefloxacin or related drugs when given together. ,
Ref :-   Book : Martindale    Page : 267   Edition : 38,


►  Contraindication : Pregnant and lactating women, G6PD deficiency, renal impairment, Epilepsy, myasthenia gravis,
Ref :-   Book : Martindale    Page : 264,338   Edition : 38,
  ►  Mechanism of Action :   The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many gram-positive bacteria (such as S. aureus), topoisomerase IV is the primary activity inhibited by the quinolones,
Ref :-   Book : Goodman    Page : 1470   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 341   Edition : 38,


►    Plasma Half-life :
  Min value :-   8 hours,    Max value :-   13 hours,
Ref :-   Book : Goodman    Page : 1472   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,