Pegvisomant is a Medicine belongs to GH receptor antagonist group whose information about Brand can be referenced from   Book : Martindale    Page : 1965   Edition : 37,

  ►   Brandname : Somavert

  ►  Strength : Injection with 10  mg, Injection with 15  mg, Injection with 20  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 677   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC,
Reference :-   Book : Martindale    Page : 1965   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acromegaly SC 40 80 mg Injection It's loading dose.

Ref :-  Book : Martindale    Page : 1964   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : NA

►  Drug Interaction : Drug interaction of Pegvisomant is with Insulin , Lamotrigine , Ethinylestradiol ,
Ref :-   Book : Martindale    Page : 1964   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Pegvisomant may increase insulin sensitivity. In patients with diabetes, doses of insulin or oral hypoglycaemics may need to be decreased because of the increased risk of hypoglycaemia. Patients taking opioid analgesics may require higher serum concentrations of pegvisomant to achieve appropriate IGF-I suppression.,
Ref :-   Book : Martindale    Page : 1964   Edition : 37,


►  Contraindication : Hypersensitivity, ,
Ref :-   Book : Martindale    Page : 477   Edition : 37,
  ►  Mechanism of Action :   Antagonize GH receptor ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 477   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1965   Edition : 37,


►    Plasma Half-life :
  Min value :-   74 hours,    Max value :-   172 hours,
Ref :-   Book : Martindale    Page : 1965   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   33 hours,    Max value :-   77 hours,
Ref :-   Book : Martindale    Page : 1965   Edition : 37,