Pegvisomant is a Medicine belongs to Growth hormone and its modulators group whose information about Brand can be referenced from   Book : Martindale    Page : 1965   Edition : 37,

  ►   Brandname : Somavert

  ►  Strength : Injection with 10  mg, Injection with 15  mg, Injection with 20  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 677   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC,
Reference :-   Book : Martindale    Page : 1965   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acromegaly SC 40 80 mg Injection Given above is a loading dose followed by 10 mg daily.

Ref :-  Book : Martindale    Page : 1928   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Common adverse effects:, GI disturbances, elevation of liver-function test values, flu-like symptoms, fatigue, injection-site reactions, arthralgia, myalgia, peripheral oedema, headache, Dizziness, Somnolence, tremor, sweating, pruritus, Rashes, sleep disorders, hypercholesterolaemia, weight gain, hyperglycemia, hunger, hypertension,
Ref :-   Book : Martindale    Page : 1928   Edition : 38,

►  Drug Interaction : Drug interaction of Pegvisomant is with Insulin , Lamotrigine , Ethinylestradiol ,
Ref :-   Book : Martindale    Page : 1964   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Pegvisomant may increase insulin sensitivity. In patients with diabetes, doses of insulin or oral hypoglycaemics may need to be decreased because of the increased risk of hypoglycaemia. Patients taking opioid analgesics may require higher serum concentrations of pegvisomant to achieve appropriate IGF-I suppression.,
Ref :-   Book : Martindale    Page : 1928   Edition : 38,


►  Contraindication : Hypersensitivity, ,
Ref :-   Book : Martindale    Page : 477   Edition : 37,
  ►  Mechanism of Action :   Pegvisomant is a protein of recombinant DNA origin to which several polyethylene glycol polymers are covalently bound. It is an analogue of human growth hormone that acts as an antagonist at growth hormone receptors, and is used in the treatment of acromegaly.,
Ref :-   Book : Martindale    Page : 1928   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1965   Edition : 37,


►    Plasma Half-life :
  Min value :-   Range from 74 hours,    Max value :-   172 hours,
Ref :-   Book : Martindale    Page : 1965   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   Occur after about 33 hours,    Max value :-   77 hours,
Ref :-   Book : Martindale    Page : 1965   Edition : 37,