Pemetrexed Disodium is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 838-839   Edition : 37,

  ►   Brandname : Alimta

  ►  Strength : Injection with 500  mg/m2,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 838   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM,
Reference :-   Book : Martindale    Page : 838   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Lung cancer IV infusion 500 mg/m2 Injection Given as monotherapy or with cisplatin; as infusion over 10 minutes.

Ref :-  Book : Martindale    Page : 838,839   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : fatigue, stomatitis, pharyngitis, dyspnoea, chest pain, neuropathy, hepatitis, colitis, interstitial pneumonitis, fatalities,
Ref :-   Book : Martindale    Page : 838,839   Edition : 37,

►  Drug Interaction : Drug interaction of Pemetrexed Disodium is with Ropivacaine , Aspirin,
Ref :-   Book : Martindale    Page : 838,839   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  High doses of NSAIDs and aspirin may decrease pemetrexed elimination. In patients with mild to moderate renal impairment (creatinine clearance 45 to 79 mL/minute) high doses of NSAIDs and aspirin should be avoided from 2 days before until 2 days after pemetrexed use,
Ref :-   Book : Martindale    Page : 838-839   Edition : 37,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Martindale    Page : 838-839   Edition : 37,
  ►  Mechanism of Action :   Pemetrexed is primarily a thymidylate synthase inhibitor like raltitrexed , but it also inhibits other folate-dependent enzymes involved in purine synthesis such as dihydrofolate reductase and glycinamide ribonucleotide formyltransferase,
Ref :-   Book : Martindale    Page : 838-839   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 838   Edition : 37,


►    Plasma Half-life :
  Min value :-   3.5 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 838   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,