Penicillamine is a Medicine belongs to Disease modifying antirheumatic drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1601   Edition : 37,

  ►   Brandname : Cilamin,Distamine,Cuprimine,Depen

  ►  Strength : Capsule with 125  mg, Capsule with 250  mg, Tablet with 250  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Wilson’s disease Oral 1.5 2 gm Given daily in divided doses initially.
2 Lead poisoning Oral 1 1.5 gm Given daily in divided doses until urinary lead is stabilised at less than 500 micrograms/day.
3 Cystinuria Oral 1 4 gm Given daily in divided doses.
4 Severe active rheumatoid arthritis Oral 125 250 mg o.d.
5 Chronic active hepatitis Oral 500 mg Given daily in divided doses.

Ref :-  Book : Martindale    Page : 1600   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Lead poisoning Oral 15 20 mg/kg
2 Cystinuria Oral 20 30 mg/kg
3 Wilson’s disease >=11 Year Oral 20 mg/kg

Ref :- Book : Martindale    Page : 1567   Edition : 38,
Precaution :- If a Patient is using 'Penicillamine' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution (may cause MG) .

Precaution :- If a Patient is using 'Penicillamine' drug in acute kidney injury disease, then Please use with caution   if he ever suffered from WILSONS DISEASE disease.
►  Side Effect : anorexia, nausea, vomiting, oral ulceration, stomatitis, pruritus, Urticaria, fever, lupus erythematosus, pemphigus, Stevens-Johnson syndrome, thrombocytopenia, haemolytic anaemia, leucopenia, glomerulonephritis, granulocytopenia, nephrotic syndrome, haematuria, Goodpasture’s syndrome, bronchitis, pneumonitis, myasthenia gravis, polymyositis, intrahepatic cholestasis, Pancreatitis, cardiac involvement,
Ref :-   Book : Martindale    Page : 1598   Edition : 37,

►  Drug Interaction : Drug interaction of Penicillamine is with Iron , Probenecid , Sildenafil ,
Ref :-   Book : Martindale    Page : 1600   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Penicillamine forms chelates with metal ions and oral absorption may be reduced if it is given with iron or other metals, antacids, or food.,
Ref :-   Book : Martindale    Page : 1600   Edition : 37,


►  Contraindication : lupus erythematosus, aplastic anaemia, thrombocytopenia, renal impairment,
Ref :-   Book : Martindale    Page : 1599   Edition : 37,
  ►  Mechanism of Action :   Penicillamine is a chelator that aids the elimination from the body of certain heavy-metal ions, including copper, lead, and mercury, by forming stable soluble complexes with them that are readily excreted by the kidney. ,
Ref :-   Book : Martindale    Page : 1600   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- IRON with Penicillamine bind iron .When this drug is taken with iron the absorption and activity of drug is reduced .Form chelate with iron , BROMELAIN with It improved the action of drug ., GUARGUM with Guar gum reduced the absorption of drug ., CALCIUM with Form chelate with calcium ., IRON with Penicillamine bind iron .When this drug is taken with iron the absorption and activity of drug is reduced .Form chelate with iron , IRON with Impairs B6 metabolism & increases urinary excretion ., COPPER with Increases urinary mineral excretion ., ZINC with Increases urinary mineral excretion .,

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • MOHAMMAD ISMAIL, *MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • MOHAMMAD ISMAIL, *MOHAMMAD.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • MOHAMMAD ISMAIL, *MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://ajpcr.com/Vol2Issue4/226.pdf,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1600   Edition : 37,


    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 1600   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 1600   Edition : 37,