Pentazocine is a Medicine belongs to Analgesic opoids group whose information about Brand can be referenced from   Book : Martindale    Page : 121   Edition : 38  

  ►   Brandname : Forstar, Fortwin, Pentawin, Peltazon, Pentagin, Talwin, Fortral
  ►  Strength : Injection with 30 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 562   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, SC, IM, IV, rectal
Reference :-   Book : Martindale    Page : 341   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Obstetric analgesia IM Injection Given 30 mg as a single dose during labour. Alternatively, 20 mg may be given by intravenous injection as soon as contractions occur at regular intervals and repeated 2 or 3 times at intervals of 2 to 3 hours if necessary.

Ref :-  Book : Martindale    Page : 121   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Moderate to severe pain Oral

Ref :- Book : Martindale    Page : 121   Edition : 38  
►  Side Effect : Nausea, Vomiting, Constipation, Drowsiness, Confusion, Dry mouth, Dizziness, Sweating, Facial flushing, Headache, Vertigo, Bradycardia, Tachycardia, palpitations, Orthostatic hypotension, Hypothermia, Restlessness, Changes of mood, Decreased libido, Hallucinations, Miosis, Agranulocytosis, Skin reaction, Erythema multiforme, Toxic epidermal necrolysis, Local tissue damage, Ureteric or biliary spasm, Difficulty in micturition, Antidiuretic effect, Muscle rigidity reported after high doses, The euphoric activity of opioids has led to their abuse
Ref :-   Book : Martindale    Page : 106, 117   Edition : 37.   Martindale    Page : 106,117   Edition : 37.   Martindale    Page : 110   Edition : 38.  

►  Drug Interaction : Drug interaction of Pentazocine is with Mexiletine , Cisapride , Metoclopramide , Domperidone , Ciprofloxacin , Zonisamide , Oxcarbazepine
Ref :-   Book : Martindale    Page : 107,117   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  The actions of opioids may in turn affect the activities of other drugs. For instance, their gastrointestinal effects may delay absorption as with mexiletine or may be counteractive as with cisapride, metoclopramide, or domperidone. Opioid premedicants such as papaveretum have been reported to reduce serum concentrations of ciprofloxacin
Ref :-   Book : Martindale    Page : 107   Edition : 37.  


►  Contraindication : Respiratory depression, Obstructive airway disease, Acute alcoholism, Convulsive disorders, Head injury, Myocardial infraction, Heart failure, Pulmonary hypertension
Ref :-   Book : Martindale    Page : 107,117   Edition : 37.  
  ►  Mechanism of Action :   Pentazocine, a benzomorphan derivative, is an opioid analgesic that has mixed opioid agonist and antagonist actions. Agonist activity is thought to be mainly at κ opioid receptors (with possibly some σ receptor activity); it acts as a weak antagonist or partial agonist at μ receptors.
Ref :-   Book : Martindale    Page : 117   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal
Ref :-   Book : Martindale    Page : 117   Edition : 37.  

►    Plasma Half-life :   Min value :-   After an oral dose; 2 ,    Max value :-   3 hours.  
Ref :-   Book : Martindale    Page : 121   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   After an oral dose; 1,    Max value :-   3 hours.  
Ref :-   Book : Martindale    Page : 121   Edition : 38.