Pentobarbitone/Pentobarbital is a Medicine belongs to Barbiturates group whose information about Brand can be referenced from   Book : Martindale    Page : 1122   Edition : 37,

  ►   Brandname : Nembutal

  ►  Strength : Capsule with 50  mg, Capsule with 100  mg, Elixir with 4  mg/ml, Suppository with 30  mg, Suppository with 60  mg, Suppository with 120  mg, Suppository with 200  mg, Injection with 30  mg/ml, Injection with 60  mg/ml, Injection with 65  mg, Injection with 120  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 387   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : parentral, Oral, rectal,
Reference :-   Book : Martindale    Page : 1122   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Insomnia Oral 100 200 mg h.s.

Ref :-  Book : Martindale    Page : 1122   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Status epilecticus 13 mg/kg

Ref :- Book : Nelson's textbook of Pediatrics    Page : 2039   Edition : 19,
►  Side Effect : drowsiness, Sedation, ataxia, CNS depression, respiratory depression, headache, gastrointestinal disturbance, Skin reactions, Confusion, hepatitis, memory defect, megaloblastic anaemia, cholestasis, photosensitivity, hypotension, shock, laryngospasm, Apnoea,
Ref :-   Book : Martindale    Page : 1064   Edition : 37,

►  Drug Interaction : Drug interaction of Pentobarbitone/Pentobarbital is with Zonisamide , Acarbose ,
Ref :-   Book : Martindale    Page : 1064   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Sedation or respiratory depression may be enhanced by drugs with CNS-depressant properties; in particular alcohol should be avoided. Barbiturates generally induce liver enzymes, and thus increase the rate of metabolism (and decrease the activity) of many other drugs as well as endogenous substances. Continued use may result in induction of their own metabolism. MAOIs may prolong the CNS depressant effects of some barbiturates, probably by inhibition of their metabolism. However, MAOIs, like other antidepressants, also reduce the convulsive threshold and thereby antagonise the anticonvulsant action of barbiturates.,
Ref :-   Book : Martindale    Page : 1064   Edition : 37,


►  Contraindication : depression, pulmonary insufficiency, sleep apnea, CNS depression, coma, hepatic impairment,
Ref :-   Book : Martindale    Page : 1064   Edition : 37,
  ►  Mechanism of Action :   Bind to specific GABAA receptor subunits at CNS neuronal synapsis increasing duration of GABA mediated chloride ion channel opening enhance membrane hyperpolarization.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 386   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- with Long -term anticonvulsant treatment decrease blood levels of biotin .,

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- CAPSCUCIN with Capsicum decrease the absorbtion of pentobarbital,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1122   Edition : 37,


    ►    Plasma Half-life :   Min value :-   15 hours,    Max value :-   50 hours,
    Ref :-   Book : Martindale    Page : 1122   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,