Pentoxifylline is a Medicine belongs to Drugs for peripheral artery disease group whose information about Brand can be referenced from   Book : Harrison's principles of internal medicine    Page : 1501-1502   Edition : 37, Martindale    Page : 1501-1502   Edition : 37,

  ►   Brandname : Trental,Neotren,Kinetal,Trental,Neotren

  ►  Strength : Tablet (Extended Release Tablets) with 400  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 209   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1501   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Peripheral vascular disease Oral 400 mg Tablet t.i.d.

Ref :-  Book : Martindale    Page : 1501   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, gastrointestinal disturbance, Dizziness, headache, flushing, angina, palpitations, cardiac arrhythmia, hypersensitivity reactions, bleeding,
Ref :-   Book : Martindale    Page : 1501   Edition : 37,

►  Drug Interaction : Drug interaction of Pentoxifylline is with Clopamide , Insulin , Exenatide , Ketorolac trometamol, Meloxicam , Theophylline ,
Ref :-   Book : Martindale    Page : 1501   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Pentoxifylline may potentiate the effect of antihypertensives. High parenteral doses of pentoxifylline may enhance the action of insulin and oral hypoglycaemics in diabetic patients. Pentoxifylline should not be given with ketorolac as there is reported to be an increased risk of bleeding and/or prolongation of the prothrombin time. There may also be an increased risk of bleeding during use with meloxicam. Serum levels of theophylline may be raised by pentoxifylline.,
Ref :-   Book : Martindale    Page : 1501   Edition : 37,


►  Contraindication : cerebral haemorrhage, Arrhythmia, myocardial infarction , ischaemic heart disease, , hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 1501   Edition : 37,
  ►  Mechanism of Action :   Pentoxifylline , a xanthine derivative, is thought to act by reducing the viscosity of blood, allowing it to flow more easily through partially obstructed areas.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 207   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Allin & Allicin have improve blood flow --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- VITAMIN E with It reduce damage to normal tissue caused by radiation therapy .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1501   Edition : 37,


    ►    Plasma Half-life :   Min value :-   0.4 hours,    Max value :-   0.8 hours,
    Ref :-   Book : Martindale    Page : 1501   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,