Pergolide is a Medicine belongs to Antiparkinsonian Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 911   Edition : 38  

  ►   Brandname : Permax
  ►  Strength : Tablet with 0.05 mg.  Tablet with 0.25 mg.  Tablet with 1 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 498   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 910   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Parkinson’s disease For use as monotherapy an initial dose equivalent to 50 micrograms of pergolide is given on the first evening of therapy. The dose is thereafter gradually increased: 50 micrograms twice daily is taken on days 2 to 4, then increased by 100 to 250 micrograms every 3 or 4 days, given in 3 divided doses, up to a daily dose of 1.5 mg at day 28. After day 30, the dose should be increased further by a maximum of 250 micrograms twice a week until an optimum response is achieved. Usual maintenance doses are 2.1 to 2.5 mg daily; doses above 3 mg daily are not recommended by the EMEA. The daily dose is usually given in 3 divided doses.
2 Parkinson’s disease For use as adjunctive therapy with levodopa, pergolide should be introduced gradually and during this period patients can have their levodopa dosage decreased gradually until an optimum response is achieved. The initial dose of pergolide is the equivalent of 50 micrograms daily for the first 2 days, increased gradually by 100 or 150 micrograms every third day over the next 12 days of therapy. Further increases of 250 micrograms may then be made every third day until an optimum response is achieved. A usual maintenance dose is 3 mg daily; doses above 3 mg daily are not recommended by the EMEA. The daily dose is usually given in 3 divided doses.

Ref :-  Book : Martindale    Page : 910   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : It is no longer available in the United States because its use has been associated with the development of valvular heart disease
Ref :-   Book : Basic & Clinical pharmacology    Page : 489   Edition : 12.  

►  Drug Interaction : Drug interaction of Pergolide is with Phenothiazines, Butyrophenones, Thioxanthenes, , Macrolide antibacterials,  Metoclopramide , Memantine hydrochloride , Octreotide
Ref :-   Book : Martindale    Page : 899,910   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Dopamine antagonists such as the phenothiazines, butyrophenones, thioxanthenes, and metoclopramide might be expected to reduce the prolactin- lowering and the antiparkinsonian effects of pergolide and domperidone might reduce its prolactin- lowering effect. Memantine may enhance the effects of pergolide. Stimulants of gastrointestinal motility such as macrolide antibacterials or octreotide can increase the bioavailability of pergolide.
Ref :-   Book : Martindale    Page : 899,910   Edition : 38.  


►  Contraindication : NA
  ►  Mechanism of Action :   Pergolide mesilate, an ergot derivative, is a dopamine D2-agonist with actions and uses similar to those of bromocriptine but in contrast to bromocriptine (a dopamine D2-agonist) it also has agonist properties at D1 and D3 receptors.
Ref :-   Book : Martindale    Page : 910   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fava beans i.e. bakla with same compound.  

  ►  Pathway with its reference as follows :-
  • Fava beans rich in levo-dihydroxyphenylalanine(L-Dopa) the precursor of dopamine. --- (Mehran S.M., Mohseni. "Simultaneous Determination Of Levodopa And Carbidopa From Fava Bean, Green Peas And Green Beans By High Performance Liquid Gas Chromatography". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2013): n. pag. Web. 10 Nov. 2016. )

  •   ►  URL --
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708185/ .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Nirgandhi interact with dopamine agonist drug.  

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 911   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA