Perindopril is a Medicine belongs to Angiotensin-conveting Enzyme Inhibitors group whose information about Brand can be referenced from   Book : Martindale    Page : 1503   Edition : 37,

  ►   Brandname : Coversyl,Aceon

  ►  Strength : Tablet with 2  Mg, Tablet with 4  mg, Tablet with 8  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 224   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1502   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 4 mg Tablet o.d. Given as erbumine salt.
2 Heart failure Oral 2 mg Tablet Given as erbumine salt in the morning.
3 Ischaemic heart disease Oral 4 mg Tablet o.d. Given as erbumine salt for 2 weeks.

Ref :-  Book : Martindale    Page : 1503   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : hypotension, Dizziness, fatigue, headache, nausea, gastrointestinal disturbance, angioedema, Skin rashes, photosensitivity, alopecia, hypersensitivity reactions, neutropenia, agranulocytosis, renal failure, stomatitis, abdominal pain, Pancreatitis, hepatocellular injury, cholestatic jaundice, muscle cramp, paraesthesia, mood changes, Sleep disturbances, impotence, dry cough, respiratory symptoms,
Ref :-   Book : Martindale    Page : 1315   Edition : 37,

►  Drug Interaction : Drug interaction of Perindopril is with Tenecteplase , Clopamide , Zonisamide , Magnesium/Magnesium Sulphate, Ropivacaine ,
Ref :-   Book : Martindale    Page : 1318   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Excessive hypotension may occur when ACE inhibitors are used with diuretics, other antihypertensives, or other agent including alcohol. An additive hyperkalaemic effect is possible in patients receiving ACE inhibitors with potassiumsparing diuretics, potassium supplements.,
Ref :-   Book : Martindale    Page : 1318   Edition : 37,


►  Contraindication : renal failure, pregnancy,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3,
  ►  Mechanism of Action :   Inhibition of ACE decreases conversion of angiotensin (AT) to ATII, and thereby decreases arteriolar vasoconstriction, aldosetrone synthesis, renal proximal tubule NaCl reabsorption, and ADH release. ACE inhibitorsalso inhibit the degradation of bradykinin, anthereby increase vasodilation. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Achillea fragrantissima with same pathway, Rhei Rhizoma with same pathway, Rhazya stricta with same pathway, Moringa peregrina with same pathway,

  ►  Pathway with its reference as follows :-
  • Achillea fragrantissima act as ACE inhibitor . --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )
  • Rhazya stricta act as ACE inhibitor . --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )
  • Rhazya stricta act as ACE inhibitor . --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )
  • Moringa peregrina act as ACE inhibitor. --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )

  •   ►  URL -- http://www.academicjournals.org/journal/JMPR/article-abstract/3FB279457381,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Enhancer, POTASSIUM with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- POTASSIUM with Increase the risk of hyperkalemia ., CAPSICUM with Cause risk of cough ,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Mohan, L. (2013). Antihypertensive Drugs Interaction with Herbal Medicine – Review. International Journal Of Pharmaceutical And Phytopharmacological Research (Eijppr), 3(2), 139-143.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://eijppr.com/vol3-issue2/eIJPPR-2013-3-2-139-143.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1502   Edition : 37,


    ►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1502   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1502   Edition : 37,