Pethidine/Meperidine is a Medicine belongs to opioid analgesics group whose information about Brand can be referenced from   Book : Martindale    Page : 124   Edition : 38  

  ►   Brandname : Demerol,Dolcontral
  ►  Strength : Tablet with 50 mg.  Tablet with 100 mg.  Syrup with 50 mg/5mL.  Injection with 10 mg.  Injection with 25 mg.  Injection with 50 mg.  Injection with 75 mg.  Injection with 100 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 562   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV, SC
Reference :-   Book : Martindale    Page : 119   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Pain relief Oral 50 150 mg Tablet May be given every 4 hours.
2 Postoperative pain s.c/ i.m 25 100 mg Injection Drug may be given every 2 to 3 hours if necessary.
3 Obstetric analgesia s.c/ i.m 50 100 mg Injection Given as soon as contractions occur at regular intervals. This dose may be repeated after 1 to 3 hours if necessary up to a maximum of 400 mg in 24 hours.
4 Premedication IM 25 100 mg Injection Given 1 hour before surgery.
5 Adjunct to anaesthesia slow i.v 10 25 mg Injection

Ref :-  Book : Martindale    Page : 123   Edition : 38   Martindale    Page : 119   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Pain relief 2 Month 12 Year Oral 0.5 2 mg/kg
2 Pain relief 2 Month 12 Year s.c/ i.m 0.5 2 mg/kg Injection
3 Pain relief 12 Year 18 Year Oral 50 100 mg Tablet
4 Pain relief 12 Year 18 Year s.c/ i.m 25 100 mg Injection
5 Premedication IM 1 2 mg/kg Injection

Ref :- Book : Martindale    Page : 120   Edition : 37  
►  Side Effect : Sweating, Facial flushing, Vertigo, Bradycardia, Tachycardia, palpitations, Orthostatic hypotension, Hypothermia, Restlessness, Changes of mood, Decreased libido, Hallucinations, Miosis, Hypersensitivity reactions, Increase in heart rate, Dry mouth, Constipation, Nausea, Euphoria, Mydriasis, Vomiting, Dizziness, Headache, Sedation, Urinary retention, pruritus, Serious adverse effects are, Respiratory depression, Hypotension, Confusion, Abuse potential
Ref :-   Book : Martindale    Page : 106,118   Edition : 37.   Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 280,281   Edition : 3.  

►  Drug Interaction : Drug interaction of Pethidine/Meperidine is with Phenothiazines, Monoamine Oxidase Inhibitors,  Ritonavir, Moclobemide , Selegiline
Ref :-   Book : Martindale    Page : 123   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Very severe reactions, including coma, severe respiratory depression, cyanosis, and hypotension have occurred in patients receiving MAOIs (including moclobemide and selegiline) and given pethidine. There are also reports of hyperexcitability, convulsions, tachycardia, hyperpyrexia, and hypertension. Pethidine should not be given to patients receiving MAOIs or within 14 days of their discontinuation. Use of pethidine with phenothiazines has produced severe hypotensive episodes and may prolong the respiratory depression due to pethidine. Plasma concentrations of norpethidine are increased by ritonavir with a resultant risk of toxicity; use together should be avoided.
Ref :-   Book : Martindale    Page : 123   Edition : 38.  


►  Contraindication : Concomitant use of MAO inhibitor
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 281   Edition : 3.  
  ►  Mechanism of Action :   Pethidine, a phenylpiperidine derivative, is a synthetic opioid analgesic that acts mainly as a μ opioid agonist.
Ref :-   Book : Martindale    Page : 119   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal
Ref :-   Book : Martindale    Page : 119   Edition : 37.  

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   After Oral dose; 1 hours,    Max value :-   2 hours.  
Ref :-   Book : Martindale    Page : 123   Edition : 38.