Pethidine/Meperidine is a Medicine belongs to Analgesic opoids group whose information about Brand can be referenced from   Book : Martindale    Page : 120   Edition : 37,

  ►   Brandname : Demerol

  ►  Strength : Tablet with 50  mg, Tablet with 100  mg, Tablet with 50/5  mg/ml, Injection with 10  mg, Injection with 25  mg, Injection with 50  mg, Injection with 75  mg, Injection with 100  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 562   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV, SC,
Reference :-   Book : Martindale    Page : 119   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info

Ref :-  Book :




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : NA

►  Drug Interaction : Drug interaction of Pethidine/Meperidine is with Mexiletine , Cisapride , Metoclopramide , Domperidone , Ciprofloxacin , Acarbose , Phenothiazine, Ritonavir,
Ref :-   Book : Martindale    Page : 107,119   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The actions of opioids may in turn affect the activities of other drugs. For instance, their gastrointestinal effects may delay absorption as with mexiletine or may be counteractive as with cisapride, metoclopramide, or domperidone. Opioid premedicants such as papaveretum have been reported to reduce serum concentrations of ciprofloxacin. Very severe reactions, including coma, severe respiratory depression, cyanosis, and hypotension have occurred in patients receiving MAOIs (including moclobemide and selegiline) and given pethidine. There are also reports of hyperexcitability, convulsions, tachycardia, hyperpyrexia, and hypertension. Pethidine should not be given to patients receiving MAOIs or within 14 days of their discontinuation. Use of pethidine with phenothiazines has produced severe hypotensive episodes and may prolong the respiratory depression due to pethidine. Plasma concentrations of norpethidine are increased by ritonavir. ,
Ref :-   Book : Martindale    Page : 107,119   Edition : 37,


►  Contraindication : respiratory depression, Obstructive airway disease, Acute alcoholism, convulsive disorder, head injury,
Ref :-   Book : Martindale    Page : 107,118   Edition : 37,
  ►  Mechanism of Action :   Pethidine, a phenylpiperidine derivative, is a synthetic opioid analgesic that acts mainly as a μ opioid agonist.,
Ref :-   Book : Martindale    Page : 119   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 119   Edition : 37,


►    Plasma Half-life :
  Min value :-   3 hours,    Max value :-   6 hours,
Ref :-   Book : Martindale    Page : 119   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
Ref :-   Book : Martindale    Page : 119   Edition : 37,