Phenoxymethylpenicillin is a Medicine belongs to PENICILLINS group whose information about Brand can be referenced from   Book : Martindale    Page : 339   Edition : 38,

  ►   Brandname : Kaypen,Pen-Vee K

  ►  Strength : Tablet with 250  mg, Tablet with 500  mg, Solution with 125/5  mg/ml, Solution with 250/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 341   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Rheumatic fever Oral 250 mg b.d. Given to prevent recurrences of rheumatic fever.
2 Group A streptococcal infection Oral 250 500 mg q.i.d. Given for 10 days to prevent secondary cases of invasive group A streptococcal infection.
3 Pneumococcal infection Oral 250 mg b.d. Given for prophylaixs of infection in asplenia, or in patients with sickle-cell disease; Also Ref 2, pg no. 339 ed. 38th.
4 Diphtheria Oral 125 250 mg q.i.d. Given for 14-day course. Also ref 2, pg no. 339 ed. 38th.

Ref :-  Book : Martindale    Page : 339   Edition : 38, Harrison's principles of internal medicine    Page : 1191   Edition : 18,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Gram positive cocci Oral 25 50 mg/kg/day
2 Gram-negative bacteria Oral 25 50 mg/kg/day
3 ACUTE RHEUMATIC FEVER Oral 250 mg b.d.
4 Streptococcal pharyngitis <27 250 mg b.d/t.i.d
5 Streptococcal pharyngitis >27 500 mg b.d/t.i.d
6 Actinomycosis Oral 100 mg/kg/day
7 VULVOVAGINAL INFECTION Oral 250 mg b.d/t.i.d
8 Hereditary spherocytosis <5 Year Oral 125 mg Solution b.d.
9 Hereditary spherocytosis Oral 250 mg b.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 903, 929, 918, 924, 1439, 1440, 1661, 1868.   Edition : 19,
►  Side Effect : nausea, diarrhea, hypersensitivity reactions, allergic reaction, anaphylaxis, angioedema, erythema multiforme, Hepatic injury , renal impairment, haemolytic anaemia, neutropenia, prolongation of bleeding time, defective platelet function, Nephropathy, interstitial nephritis, convulsion, encephalopathy, electrolyte disturbances,
Ref :-   Book : Martindale    Page : 219,338   Edition : 38,

►  Drug Interaction : Drug interaction of Phenoxymethylpenicillin is with Probenecid ,
Ref :-   Book : Martindale    Page : 339   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Probenecid prolongs the half-life of Penicillin V by competing with it for renal tubular secretion and may be used therapeutically for this purpose.,
Ref :-   Book : Martindale    Page : 339   Edition : 38,


►  Contraindication : Hypersensitivity, penicillins, Allergy, renal impairment,
Ref :-   Book : Martindale    Page : 235   Edition : 38,
  ►  Mechanism of Action :   It inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Phenoxymethylpenicillin is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 341   Edition : 38,


►    Plasma Half-life :
  Min value :-   0.5 hours,    Max value :-   1 hours,
Ref :-   Book : Martindale    Page : 341   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   0.5,    Max value :-   1 hours,
Ref :-   Book : Martindale    Page : 341   Edition : 38,