Phenprocoumon is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1468   Edition : 38  

  ►   Brandname : Marcumar, Phenpro, Marcuphen
  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : NA

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Thromboembolic disorders Initial doses are up to 9 mg on the first day followed by 6 mg on the second day. Maintenance doses are usually from 1.5 to 6 mg daily, depending on the response.

Ref :-  Book : Martindale    Page : 1468   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Haematoma, Anaemia, Skin necrosis, Purple discolouration of toes, Alopecia, Fever, Vomiting, Nausea, Diarrhea, Jaundice, Hepatic dysfunction, Pancreatitis
Ref :-   Book : Martindale    Page : 1468,1528   Edition : 38.  

►  Drug Interaction : Drug interaction of Phenprocoumon is with , , , Analgesic, , Contrast media , Alcohol, Barbiturates , , Non Sterodial Anti- Inflammatory Drugs , ,  Cimetidine , Sulfamethoxazole and Trimethoprim (Co-trimoxazole), Phenylbutazone, Aspirin, Clofibrate, L-asparaginase, Epoprostenol, Streptokinase , Urokinase , Acetomenaphthone, Aminoglutethimide , Bosentan , Carbamazapine , Dichloralphenazone, Ethchlorvynol, Glutethimide, Chloral hydrate, Griseofulvin , Nafcillin, Phytomenadione, Rifampicin , Allopurinol , Amiodarone , Cefamandole, Chloramphenicol , Danazol, Dextropropoxyphene, Dextrothyroxine, Dipyridamole , Erythromycin , Etacrynic acid, Ethylestrenol, Fluconazole , Glucagon , Itraconazole , Ketoconazole , Metronidazole , Miconazole, Norethandrolone, Oxymetholone , Quinidine , Stanozolol, Sulfinpyrazone, Tamoxifen citrate , Telithromycin, Tramadol , Triclofos sodium
Ref :-   Book : Martindale    Page : 1468,1530   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Many compounds interact with warfarin (and Phenprocoumon) and other oral anticoagulants. Interactions of a pharmacodynamic nature occurring with one anticoagulant may well apply to another but this may not be the case with pharmacokinetic interactions. Many food and herbal preparations also have the potential to interact with oral anticoagulants. An interaction may be due to increased or decreased anticoagulant metabolism; with warfarin some interacting drugs such as cimetidine, co-trimoxazole, or phenylbutazone have a selective effect on its stereoisomers. Altered absorption may sometimes play a part, as with colestyramine. Displacement of oral anticoagulants from plasma protein binding sites has been reported with many drugs, including some analgesics. Not all reports that have recorded an alteration in the pharmacokinetics of the anticoagulant have, however, shown a corresponding change in clinical response. Interference with the coagulation process may be responsible for the increased risk of haemorrhage when aspirin, clofibrate, or thyroid hormones are used with anticoagulants. Many other compounds, such as asparaginase, some contrast media, epoprostenol, streptokinase, and urokinase also carry this risk; while interactions between these compounds and anticoagulants are not discussed further below, the possibility of an increased risk of haemorrhage should be considered when they are used together. Where there is a risk of serious haemorrhage from an interaction, then use of both drugs is best avoided. In other instances the anticoagulant activity should be carefully monitored so as to increase or decrease the anticoagulant dose as required. Drugs generally recognised as diminishing the effects of oral anticoagulants are included in the following list. Acetomenaphthone, alcohol (chronic ingestion without liver impairment), aminoglutethimide, barbiturates, bosentan, carbamazepine, dichloralphenazone, ethchlorvynol, glutethimide, griseofulvin, nafcillin, phytomenadione, rifampicin, St John’s wort. Drugs recognised or generally reported as enhancing oral anticoagulants are included in the following list. alcohol (acute ingestion or chronic ingestion with liver impairment), allopurinol, amiodarone, aspirin, cefamandole, chloramphenicol, cimetidine, clofibrate, cloral hydrate, co-trimoxazole, danazol, dextropropoxyphene, dextrothyroxine, dipyridamole, disulfiram, erythromycin, etacrynic acid, ethylestrenol, fluconazole, glucagon, itraconazole, ketoconazole, metronidazole, miconazole, norethandrolone, NSAIDs, oxymetholone, quinidine, stanozolol, sulfinpyrazone, tamoxifen, telithromycin, thyroid agents, tramadol, triclofos sodium.
Ref :-   Book : Martindale    Page : 1468,1530   Edition : 38.  

►  Contraindication : Patients who are haemorrhaging
Ref :-   Book : Martindale    Page : 1468,1529   Edition : 38.  
  ►  Mechanism of Action :   Inhibit hepatic epoxide reductase that catalyzes the regeneration of reduce vitamin k, which is required for synthesis of biologically active coagulation factors II, , VII, IX, and anticoagulant proteins C and S.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 397   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal, Faecal
Ref :-   Book : Martindale    Page : 1468   Edition : 38.  

►    Plasma Half-life :   Min value :-   around 6 days,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1468   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA