Phentermine is a Medicine belongs to Stimulants and Anorectics group whose information about Brand can be referenced from   Book : Martindale    Page : 2329   Edition : 38  

  ►   Brandname : Adipex-P, Suprenza, Duromine, Metermine
  ►  Strength : Capsules with .  Tablet with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2329   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 2329   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Obesity The usual dose of phentermine is 15 to 30 mg once daily before breakfast given as an ion-exchange resin complex that provides modified release. A suggested dose for phentermine hydrochloride is 8 mg three times daily before meals or 15 to 37.5 mg once daily in the morning. It should not be given for longer than a few weeks. Regulatory authorities in the EU have called for the withdrawal of phentermine from the market.

Ref :-  Book : Martindale    Page : 2329   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Urticaria, Common adverse effects:, Insomnia, Nervousness, Restlessness, Night terrors, irritability, Euphoria, Fatigue, Depression, There may be , Dryness of the mouth, Anorexia, Abdominal cramp, Other gastrointestinal disturbances, Headache, Dizziness, Tremor, Sweating, Tachycardia, palpitations, Myocardial infarction, Changes in libido, impotence, Increased or decreased blood pressure
Ref :-   Book : Martindale    Page : 2319,2329   Edition : 38.  

►  Drug Interaction : Drug interaction of Phentermine is with Monoamine Oxidase Inhibitors, Beta Blockers , , Tricyclic antidepressants, , , , Anorectics,  Guanethidine, Ethosuximide , Phenobarbital , Phenytoin , Chlorpromazine , Haloperidol , Lithium carbonate , Disulfiram, Halothane , Fenfluramine
Ref :-   Book : Martindale    Page : 2320,2329   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  To avoid precipitating a hypertensive crisis, Phentermine should not be given to patients being treated with an MAOI or within 14 days of stopping such treatment. Use of beta blockers with amfetamines may produce severe hypertension. Phentermine may also diminish the effects of other antihypertensives, including guanethidine and similar drugs, and concurrent use should be avoided. Patients receiving amfetamines and tricyclic antidepressants require careful monitoring as the risk of cardiovascular effects including arrhythmias may be increased. The urinary excretion of amfetamines is reduced by urinary alkalinisers, which may enhance or prolong their effects; excretion is increased by urinary acidifiers. Amfetamines may delay the absorption of ethosuximide, phenobarbital, and phenytoin. The stimulant effects of amfetamines are inhibited by chlorpromazine, haloperidol, and lithium. Disulfiram may inhibit the metabolism and excretion of amfetamines. Use of sympathomimetics i.e Phentermine with volatile liquid anaesthetics such as halothane is associated with an increased risk of cardiac arrhythmias.
Ref :-   Book : Martindale    Page : 2320,2329   Edition : 38.  


►  Contraindication : NA
  ►  Mechanism of Action :   Phentermine is a central stimulant and indirect-acting sympathomimetic with actions similar to those of dexamfetamine. It has been given orally as the base or hydrochloride as an anorectic in the short-term treatment of moderate to severe obesity, although stimulants are no longer recommended for this indication.
Ref :-   Book : Martindale    Page : 2329   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- EPHEDRA with cause overstimulation,nervousness, irritability, insomnia & seizurse or heart arrhythmias..  

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 2329   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA