Phentolamine is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1469   Edition : 38   Martindale    Page : 1504   Edition : 37  

  ►   Brandname : Fentanor, OraVerse, AnTing, Regitine
  ►  Strength : Injection with 5 mg/vial. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 166   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV
Reference :-   Book : Martindale    Page : 1505   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Phaeochromocytoma i.m or i.v 2 5 mg Injection A dose given to patients with hypertensive crises during surgery for phaeochromocytoma and repeated if necessary; blood pressure should be monitored. The intramuscular route may be used pre-operatively and for diagnostic procedures.
2 Dermal necrosis IV infusion Injection For prevention of dermal necrosis during intravenous infusion of noradrenaline, 10 mg of phentolamine mesilate is added to each litre of solution containing noradrenaline. For treatment of extravasation of noradrenaline, 5 to 10 mg of phentolamine mesilate in 10 mL of sodium chloride 0.9% is injected into the affected area.
3 Reversal of soft-tissue anaesthesia Local For Reversal of anaesthesia in the mouth; this drug is given using the same location and technique as for the local anesthetic. The dose depends on the amount of local anesthetic used and ranges from 200 to 800 micrograms.
4 Erectile dysfunction Injection Phentolamine mesilate is given by injection into the corpora cavernosa of the penis. It is usually given with papaverine, but a preparation containing phentolamine with aviptadil (vasoactive intestinal peptide) may also be used.

Ref :-  Book : Martindale    Page : 1469   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Phaeochromocytoma IV Injection
2 Reversal of soft-tissue anaesthesia 6 Year and over 15-30 kg Local 200 micrograms

Ref :- Book : Martindale    Page : 1469   Edition : 38  
►  Side Effect : Postural hypotension, Tachycardia, Palpitation, Xerostomia, Sedation, Miosis, Absence of ejaculation, Serious:, Seizure
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 145   Edition : 3.  

►  Drug Interaction : Drug interaction of Phentolamine is with Adrenaline
Ref :-   Book : Martindale    Page : 1504   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Since phentolamine only blocks alpha receptors, use with drugs such as adrenaline may lead to severe hypotension and tachycardia due to unopposed beta-adrenoceptor stimulation
Ref :-   Book : Martindale    Page : 1504   Edition : 37.  


►  Contraindication : Coronary artery disease
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 145   Edition : 3.  
  ►  Mechanism of Action :   Phentolamine is an alpha-adrenoceptor blocker which also has a direct action on vascular smooth muscle. It produces vasodilatation, an increase in cardiac output, and has a positive inotropic effect, but is reported to have little effect on the blood pressure of patients with essential hypertension. The alpha-receptor blocking action is reversible (‘competitive’) and non-selective, and the duration of effect is relatively short.
Ref :-   Book : Martindale    Page : 1504   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Beet with Another pathway.   Fish with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Having betanine and act as vasodilator --- ( Clifford, T., Howatson, G., West, D., & Stevenson, E. (2015). The Potential Benefits of Red Beetroot Supplementation in Health and Disease. Nutrients, 7(4), 2801-2822. )
  • Fish-EPA & DHA have vasodilator --- (Fleischhauer, F., Yan, W., & Fischell, T. (1993). Fish oil improves endothelium-dependent coronary vasodilation in heart transplant recipients. Journal Of The American College Of Cardiology, 21(4), 982-989. )

  •   ►  URL --
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425174/ .
  • http://content.onlinejacc.org/article.aspx?articleid=1118626 .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 1504   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   After iv doses; 19 min,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1469   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA