Phentolamine is a Medicine belongs to Adrenoceptor blockers group whose information about Brand can be referenced from   Book : Martindale    Page : 1504   Edition : 37,

  ►   Brandname : Rogitine,Regitine

  ►  Strength : Injection with 5  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 166   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV,
Reference :-   Book : Martindale    Page : 1505   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Phaeochromocytoma IV 2 5 mg Injection A dose given to patients with hypertensive crises during surgery for Phaeochromocytoma.
2 Dermal necrosis IV infusion 10 mg Injection For prevention of dermal necrosis during intravenous infusion of noradrenaline.
3 Extravasation of noradrenaline Local 5 10 mg Injection
4 Reversal of soft-tissue anaesthesia Local 200 800 micrograms For Reversal of anaesthesia in the mouth; The dose and technique to be given depends on the local anesthetic used.

Ref :-  Book : Martindale    Page : 1504   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Phaeochromocytoma IV 1 mg Injection
2 Reversal of soft-tissue anaesthesia =<6 Year 15-30 Local >=200 micrograms

Ref :- Book : Martindale    Page : 1504   Edition : 37,
►  Side Effect : Orthostatic hypotension, tachycardia, weakness, Dizziness, flushing, myocardial infarction, anginal pain, arrhythmia, nausea, vomiting, diarrhea,
Ref :-   Book : Martindale    Page : 1504   Edition : 37,

►  Drug Interaction : Drug interaction of Phentolamine is with Adrenaline,
Ref :-   Book : Martindale    Page : 1504   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Since phentolamine only blocks alpha receptors, use with drugs such as adrenaline may lead to severe hypotension and tachycardia due to unopposed beta-adrenoceptor stimulation,
Ref :-   Book : Martindale    Page : 1504   Edition : 37,


►  Contraindication : angina pectoris, ischaemic heart disease, peptic ulcer disease,
Ref :-   Book : Martindale    Page : 1504   Edition : 37,
  ►  Mechanism of Action :   Phentolamine is an alpha-adrenoceptor blocker which also has a direct action on vascular smooth muscle. It produces vasodilatation, an increase in cardiac output, and has a positive inotropic effect, but is reported to have little effect on the blood pressure of patients with essential hypertension. The alpha-receptor blocking action is reversible (‘competitive’) and non-selective, and the duration of effect is relatively short. ,
Ref :-   Book : Martindale    Page : 1504   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Beet with Another pathway, Fish with Another pathway,

  ►  Pathway with its reference as follows :-
  • Having betanine and act as vasodilator --- ( Clifford, T., Howatson, G., West, D., & Stevenson, E. (2015). The Potential Benefits of Red Beetroot Supplementation in Health and Disease. Nutrients, 7(4), 2801-2822. )
  • Fish-EPA & DHA have vasodilator --- (Fleischhauer, F., Yan, W., & Fischell, T. (1993). Fish oil improves endothelium-dependent coronary vasodilation in heart transplant recipients. Journal Of The American College Of Cardiology, 21(4), 982-989. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425174/, http://content.onlinejacc.org/article.aspx?articleid=1118626,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1504   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   0.31 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1504   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,