Phenylephrine is a Medicine belongs to Sympathomimetic Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1672   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Drosyn,Fencel,Boots Decongestant Capsules,AH-chew D,Expect-D

  ►  Strength : Tablet with 10  mg, Injection with 10  mg/ml, Spray with 0.125  %, Spray with 0.16  %, Spray with 0.25  %, Spray with 0.5  %, Spray with 1  %, Ophthalmic Solution with 0.12  %, Ophthalmic Solution with 2.5  %, Ophthalmic Solution with 10  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 148   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical, Oral, parentral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 148   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Nasal congestion Local 0.25 1 % drops Or may be sprayed into each nostril every 4 hours as required.
2 Mydriatic Topical 10 % Ophthalmic Solution
3 Conjunctival decongestant Topical 0.12 % Ophthalmic Solution
4 Hypotension s.c/ i.m 2 5 mg Injection
5 Paroxysmal supraventricular tachycardia IV 500 micrograms Injection Given as a 0.1% solution.

Ref :-  Book : Martindale    Page : 1672, 1673   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Shock 0.5 2.0
2 Nasal congestion 2 Year 6 Year Local 0.125 % Nasal Spray
3 Nasal congestion 6 Year 12 Year Local 0.25 % Nasal Spray
4 Nasal congestion >12 Year intranasal 0.25 0.5 % Nasal Spray
5 Mydriatic Topical 2.5 %

Ref :- Book : Nelson's textbook of Pediatrics    Page : 313, 780   Edition : 19,
►  Side Effect : cardiac arrhythmia, hypertension, headache, insomnia, Nervousness, rebound nasal cogestion,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 144   Edition : 3,

►  Drug Interaction : Drug interaction of Phenylephrine is with (including RIMAs),  Aminophylline , Halothane , Acarbose , Phenelzine, Moclobemide ,
Ref :-   Book : Martindale    Page : 1673   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Phenylephrine has mainly direct alpha-agonist properties and is less liable than adrenaline or noradrenaline to induce ventricular fibrillation if used as a pressor agent during anaesthesia with inhalational anaesthetics such as cyclopropane and halothane; nevertheless, caution is necessary. MAOIs like Phenelzine inhibit the metabolism of some amine drugs (notably indirect-acting sympathomimetics like Phenylephrine), which can lead to dangerous enhancement of their pressor effects. Monoamine oxidase inhibitors (MAOIs) inhibit the action of monoamine oxidase, the enzyme responsible for the metabolism of several biogenic amines and; Reversible inhibitors of monoamine oxidase type A (RIMAs) include moclobemide; therefore medicines containing sympathomimetics (like phenylephrine), should not be taken with moclobemide.,
Ref :-   Book : Martindale    Page : 438,442,1673   Edition : 37,


►  Contraindication : narrow-angle glaucoma, ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 144   Edition : 3,
  ►  Mechanism of Action :   Selectively activate alpha1 adrenergic receptors to increase peripheral vascular resistance,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 144   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Gut, Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 1672   Edition : 38,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA