Pilocarpine is a Medicine belongs to antiglaucoma drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2012   Edition : 38   Martindale    Page : 2012   Edition : 38  

  ►   Brandname : Carpine, Pilocar, Salagen, Isopto Carpine, Pilomann, Rui Er Xin
  ►  Strength : Ophthalmic Solution with 0.5 %.  Ophthalmic Solution with 1 %.  Ophthalmic Solution with 2 %.  Ophthalmic Solution with 3 %.  Ophthalmic Solution with 4 %.  Ophthalmic Solution with 6 %.  Ophthalmic Solution with 8 %.  Ophthalmic Solution with 10 %.  Gel with 4 %.  Tablet with 5 mg.  Ophthalmic sustained-release inserts with 20 mcg.  Ophthalmic sustained-release inserts with 40 mcg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 112   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical, Oral
Reference :-   Book : Basic & Clinical pharmacology    Page : 112   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Open-angle glaucoma Topical 0.5 4 % Eye Drop This drug is given with topical beta blockers or sympathomimetics. It is given up to 4 times daily, adjusted according to response. The higher strengths may sometimes be required in patients with heavily pigmented irides. Pilocarpine may be used before surgery as part of the emergency treatment of acute attacks of angle-closure glaucoma.
2 Dry mouth Oral 5 mg Tablet t.i.d. Pilocarpine hydrochloride is used in the treatment of dry mouth following radiotherapy for malignant neoplasms of the head and neck. It increases salivary flow only in patients with residual salivary gland function.This drug is given with or immediately after meals.
3 Dry eye or mouth Oral 5 mg q.i.d. Given to patients with Sjögren’s syndrome. This dose may be increased to a maximum of 30 mg daily. Treatment should be stopped if no improvement occurs after 3 months of use.

Ref :-  Book : Martindale    Page : 2010, 2011   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Nausea, Vomiting, Diarrhea, Urinary urgency, Salivation, Sweating, Cutaneous vasodilatation, Bronchial constriction
Ref :-   Book : Basic & Clinical pharmacology    Page : 109   Edition : 12.  

►  Drug Interaction : Drug interaction of Pilocarpine is with Quinine , Chloroquine , Hydroxychloroquine , Quinidine , Procainamide , Propafenone, Felbamate, Mivacurium Chloride
Ref :-   Book : Martindale    Page : 688   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Those such as quinine, chloroquine, hydroxychloroquine, quinidine, procainamide, propafenone, lithium, and the beta blockers, that have the potential to aggravate myasthenia gravis, can reduce the effectiveness of treatment with parasympathomimetics
Ref :-   Book : Martindale    Page : 688   Edition : 38.  


►  Contraindication : Acute iritis, Acute uveitis, anterior uveitis, Secondary glaucoma
Ref :-   Book : Martindale    Page : 2011   Edition : 38.  
  ►  Mechanism of Action :   Pilocarpine is a direct-acting tertiary amine parasympathomimetic that has the muscarinic effects of acetylcholine.It is used mainly in the treatment of glaucoma.
Ref :-   Book : Martindale    Page : 2010   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Leaf of Pilocarpus with same compound.  

  ►  Pathway with its reference as follows :-
  • Pilocarpine Pilosine It produces contraction of the iris sphincter muscle, resulting in pupillary constriction (miosis). --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy .
  • +C.+K.+Kokate .
  • +A.P.+Purohit .
  • +S.B.+Gokhale .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 2011   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   Mean elimination half-lives have been reported to be 0.76 and 1.35 hours after repeated oral doses.,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2011   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA