Pilocarpine is a Medicine belongs to Direct acting cholinomimetics group whose information about Brand can be referenced from   Book : Martindale    Page : 2012   Edition : 38,

  ►   Brandname : Carpine,Pilocar,Salagen,Isopto Carpine

  ►  Strength : Ophthalmic Solution with 0.5  %, Ophthalmic Solution with 1  %, Ophthalmic Solution with 2  %, Ophthalmic Solution with 3  %, Ophthalmic Solution with 4  %, Ophthalmic Solution with 6  %, Ophthalmic Solution with 8  %, Ophthalmic Solution with 10  %, Gel with 4  %, Tablet with 5  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical, Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 112   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Open-angle glaucoma Topical 0.5 4 % Eye Drop t.i.d/q.i.d
2 Dry mouth Oral 5 mg Tablet t.i.d. Given for dry mouth following radiotherapy; given with or immediately after meals.
3 Dry eye or mouth Oral 5 mg q.i.d. Given to patients with Sjögren’s syndrome.

Ref :-  Book : Martindale    Page : 2010, 2011   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, diarrhea, urinary urgency, Salivation, sweating, cutaneous vasodilatation, bronchial constriction,
Ref :-   Book : Basic & Clinical pharmacology    Page : 109   Edition : 12,

►  Drug Interaction : Drug interaction of Pilocarpine is with Quinine , Chloroquine , Hydroxychloroquine , Quinidine , Procainamide , Propafenone, Felbamate, Mivacurium Chloride ,
Ref :-   Book : Martindale    Page : 688   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Those such as quinine, chloroquine, hydroxychloroquine, quinidine, procainamide, propafenone, lithium, and the beta blockers, that have the potential to aggravate myasthenia gravis, can reduce the effectiveness of treatment with parasympathomimetics,
Ref :-   Book : Martindale    Page : 688   Edition : 38,


►  Contraindication : Acute iritis, acute uveitis, anterior uveitis, secondary glaucoma, ,
Ref :-   Book : Martindale    Page : 2011   Edition : 38,
  ►  Mechanism of Action :   To stimulate muscarinic receptor activity. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 129   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Leaf of Pilocarpus with same compound,

  ►  Pathway with its reference as follows :-
  • Pilocarpine Pilosine It produces contraction of the iris sphincter muscle, resulting in pupillary constriction (miosis). --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 2011   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   0.76 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2011   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,