Pimozide is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1124   Edition : 37,

  ►   Brandname : Orap

  ►  Strength : Tablet with 1  mg, Tablet with 2  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1124   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 2 mg Tablet o.d.
2 Monosymptomatic hypochondria Oral 4 mg Tablet Dose given daily.
3 Paranoid psychoses Oral 4 mg Tablet Dose given daily.
4 Tourette’s syndrome Oral 1 2 mg Tablet Given daily in divided doses.

Ref :-  Book : Martindale    Page : 1124   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tourette’s syndrome 2 Year 12 Year Oral 1 4 mg
2 Tourette’s syndrome 12 Year 18 Year Oral 2 10 mg Tablet

Ref :- Book : Martindale    Page : 1124   Edition : 37,
►  Side Effect : Sedation, hypotension, antimuscarinic effects, Ventricular arrhythmia, ECG abnormalities, prolong QT interval , T-wave changes, extrapyramidal effects,
Ref :-   Book : Martindale    Page : 1072   Edition : 37,

►  Drug Interaction : Drug interaction of Pimozide is with Abatacept , , Cocaine , Epinephrine (adrenaline) , Cisapride , Clarithromycin , Erythromycin , Troleandomycin, Ketoconazole , Thiamazole (Methimazole), Nefazodone, Zileuton , ,
Ref :-   Book : Martindale    Page : 1124   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The risk of arrhythmias with pimozide may be increased by other drugs that prolong the QT interval including some antiarrhythmics, other antipsychotics (including depot preparations), tricyclic antidepressants, the antihistamines terfenadine and astemizole, antimalarials, and cisapride; use together should be avoided. Pimozide with drugs thatinhibit the cytochrome P450 isoenzyme CYP3A4 is contra-indicated; the resultant decrease in the metabolism of pimozide may lead to increased plasma concentrations and hence greater risk of cardiac arrhythmias. CYP3A4 inhibitors include the macrolide antibacterials such as clarithromycin, erythromycin, and troleandomycin; the azole antifungals including itraconazole and ketoconazole; the HIV-protease inhibitors; the NNRTIs; nefazodone, and zileuton. The metabolism of pimozide may also be inhibited by grapefruit juice and use together should be avoided. ,
Ref :-   Book : Martindale    Page : 1124   Edition : 37,


►  Contraindication : prolonged QT interval , Arrhythmia,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 204   Edition : 3,
  ►  Mechanism of Action :   Antagonize mesolimbic, and possibly mesocortical, D2 receptors; adverse effects are likely mediated by binding to D2 receptors in basal ganglia (nigrostriatal pathway) and pituitary gland.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 204   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 1124   Edition : 37,


►    Plasma Half-life :
  Min value :-   55 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1124   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   12 hours,
Ref :-   Book : Martindale    Page : 1124   Edition : 37,