Pimozide is a Medicine belongs to Antipsychotics group whose information about Brand can be referenced from   Book : Martindale    Page : 1097   Edition : 38  

  ►   Brandname : Orap, Larap, Neurap
  ►  Strength : Tablet with 1 mg.  Tablet with 2 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1124   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 2 mg Tablet o.d. And adjusted thereafter according to response in increments of 2 to 4 mg at intervals of not less than 1 week.The usual does range is 2 to 20 mg daily.
2 Monosymptomatic hypochondria Oral 4 mg Tablet In monosymptomatic hypochondria and paranoid psychoses, the dose adjusted (as given in Schizophrenia) to a maximum daily dose of 16 mg. Pimozide treatment should start at half the usual initial dosage in elderly patients. Dose given daily.
3 Tourette’s syndrome Oral 1 2 mg Tablet In the USA, pimozide is only licensed for the treatment of Tourette’s syndrome; initial dose are 1 to 2 mg daily in divided doses, increased thereafter every other day to a maximum of 10 mg daily or 200 micrograms/kg daily. Dosage adjustment has been sugested for patients who are poor CYP2D6 metabolisers.

Ref :-  Book : Martindale    Page : 1097   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tourette’s syndrome Oral

Ref :- Book : Martindale    Page : 1097   Edition : 38  
►  Side Effect : Sedation, Hypotension, Antimuscarinic effects, Ventricular arrhythmia, ECG abnormalities, Prolong QT interval , T-wave changes, Extrapyramidal effects
Ref :-   Book : Martindale    Page : 1072   Edition : 37.  

►  Drug Interaction : Drug interaction of Pimozide is with Abatacept , , Cocaine , Epinephrine (adrenaline) , Cisapride , Clarithromycin , Erythromycin , Troleandomycin, Ketoconazole , Thiamazole (Methimazole), Nefazodone, Zileuton
Ref :-   Book : Martindale    Page : 1124   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  The risk of arrhythmias with pimozide may be increased by other drugs that prolong the QT interval including some antiarrhythmics, other antipsychotics (including depot preparations), tricyclic antidepressants, the antihistamines terfenadine and astemizole, antimalarials, and cisapride; use together should be avoided. Pimozide with drugs thatinhibit the cytochrome P450 isoenzyme CYP3A4 is contra-indicated; the resultant decrease in the metabolism of pimozide may lead to increased plasma concentrations and hence greater risk of cardiac arrhythmias. CYP3A4 inhibitors include the macrolide antibacterials such as clarithromycin, erythromycin, and troleandomycin; the azole antifungals including itraconazole and ketoconazole; the HIV-protease inhibitors; the NNRTIs; nefazodone, and zileuton. The metabolism of pimozide may also be inhibited by grapefruit juice and use together should be avoided. Pimozide is also metabolised by CYP2D6, albeit to a lesser extent, and in vitro data indicate that the CYP2D6 inhibitor quinidine may reduce the metabolism of pimozide; UK licensed product information contra-indicates the use of such inhibitors with pimozide. The isoenzyme CYP1A2 may also be involved in the metabolism of pimozide and consequently there is a theoretical possibility of interactions with CYP1A2 inhibitors. Pimozide should also not be used with SSRIs such as citalopram, escitalopram, paroxetine, and sertraline.
Ref :-   Book : Martindale    Page : 1097   Edition : 38.  

►  Contraindication : Pre-existing QT prolongation, Or a family history of congenital QT prolongation, History of cardiac arrhythmia
Ref :-   Book : Martindale    Page : 1097   Edition : 38.  
  ►  Mechanism of Action :   It is a dopamine receptor antagonist, may be helpful in patients as a first-line treatment or in those who are either unresponsive to or intolerant of haloperidol.
Ref :-   Book : Basic & Clinical pharmacology    Page : 495   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal
Ref :-   Book : Martindale    Page : 1124   Edition : 37.  

►    Plasma Half-life :   Min value :-   mean elimination half-life of about 55 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1097   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   It is 4 to 12 hours and there is a considerable interindividual variation in the concentrations achieved.,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1097   Edition : 38.