Pindolol is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1506   Edition : 37   Martindale    Page : 1470   Edition : 38  

  ►   Brandname : Visken, Barbloc
  ►  Strength : Tablet with 5 mg.  Tablet with 10 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1506   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 5 mg Tablet b.d/t.i.d It is usually given initially in the above doses, subsequently increased according to response. The usual maintenance dose is 15 to 30 mg once daily. Additional benefit is rarely obtained from doses higher than 45 mg daily, although doses up to 60 mg daily have been given. Pindolol has also been given intravenously in the management of cardiac arrhythmias.
2 Angina pectoris Oral Tablet The usual oral dose for angina pectoris is 2.5 to 5 mg up to three times daily; however, doses of up to 40 mg daily have been used.
3 Glaucoma Topical 1 % Eye Drop

Ref :-  Book : Martindale    Page : 1470   Edition : 38   Martindale    Page : 1506   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Sedation, Decreased libido, Depression, Dyspnoea, Wheezing, Masks symptom of hypoglycemia, Serious adverse effects are, Bronchospasm, Atrioventricular block, Bradyarrhythmia
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 146   Edition : 3.  

►  Drug Interaction : Drug interaction of Pindolol is with Angiotensin conveting enzyme inhibitors , Calcium Channel Blockers , General anaesthetics , Non Sterodial Anti- Inflammatory Drugs , Oral Hypoglycemic Drugs, Antiarrhythmics, , , , Barbiturates ,  Clonidine , Rifampicin , Cimetidine , Erythromycin , Fluvoxamine, Hydralazine , Aldesleukin , Verapamil , Digoxin , Adrenaline, Insulin
Ref :-   Book : Martindale    Page : 1321,1470   Edition : 38.   Martindale    Page : 1352   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  The characteristics of the individual beta blocker must therefore be borne in mind when considering likely interactions. Drugs that enhance the antihypertensive effects of beta blockers, such as ACE inhibitors, calcium-channel blockers, and clonidine may be useful in controlling hypertension. Drugs that cause hypotension such as aldesleukin and general anaesthetics also enhance the antihypertensive effects of beta blockers while other drugs, for example NSAIDs, antagonise the antihypertensive effects. Use of beta blockers with other cardiac depressants such as antiarrhythmics and rate-limiting calcium channel blockers can precipitate bradycardia and heart block; the combination of intravenous verapamil and beta blockers should especially be avoided. Beta blockers may potentiate bradycardia due to digoxin. The interaction between beta blockers and sympathomimetics is complex and depends on the selectivity of both drugs. Patients taking beta blockers may have an exaggerated hypertensive response to adrenaline, caused by unopposed alpha-mediated vasoconstriction, while the bronchodilator effects are inhibited. In diabetic patients beta blockers can reduce the response to insulin and oral hypoglycaemics through their effects on pancreatic beta receptors. Pharmacokinetic interactions occur with drugs that alter the absorption or metabolism of beta blockers. Although these interactions may alter the beta blocker plasma concentration, they are not usually clinically significant since there is little association between plasma concentrations and therapeutic effect or toxicity and there are wide interindividual differences in steady-state plasma concentrations of beta blockers. Drugs that reduce absorption include aluminium salts and bile-acid binding resins such as colestyramine. Metabolism of some beta blockers can be increased by drugs such as barbiturates and rifampicin and decreased with drugs such as cimetidine, erythromycin, fluvoxamine, and hydralazine.cimetidine and hydralazine decrease hepatic blood flow and this contributes to the decreased hepatic clearance seen with these drugs. Drugs that influence hepatic metabolism affect beta blockers that are extensively metabolised, such as labetalol, propranolol, and timolol, while beta blockers that are excreted largely unchanged, for example atenolol and nadolol, are unaffected. Since systemic absorption can occur after ocular use of beta blockers the possibility of similar interactions should be considered.
Ref :-   Book : Martindale    Page : 1321,1470   Edition : 38.  

►  Contraindication : Bronchial asthma or chronic obstructive pulmonary disease, Cardiogenic shock, Decompensated cardiac failure, Severe sinus bradycardia, Second and third degree AV block
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 146   Edition : 3.  
  ►  Mechanism of Action :   Pindolol is a non-cardioselective beta blocker . It is reported to have intrinsic sympathomimetic activity but little membrane-stabilising activity
Ref :-   Book : Martindale    Page : 1506   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   half-life of 3 to 4 hours has been reported in healthy adults,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1470   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   About 1 hours,    Max value :-   2 hours after oral dose..  
Ref :-   Book : Martindale    Page : 1470   Edition : 38.