Piperacillin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 341   Edition : 38   Martindale    Page : 344   Edition : 37      Page :   Edition :   

  ►   Brandname : Pentcillin, Pipracil, Microtaz
  ►  Strength : Injection with 2 gm.  Injection with 3 gm.  Injection with 4 gm. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM
Reference :-   Book : Martindale    Page : 343   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Serious or complicated infections IV 200 300 mg/kg Injection Given daily in divided doses. The usual dose is 3 to 4 g every 4 or 6 hours.
2 Life-threatening infections IV 16 gm Injection For particularly those caused by Pseudomonas or Klebsiella spp.; it should be given in a dose of not less than 16 g daily. The usual maximum daily dose is 24 g, although this has been exceeded.
3 Mild or uncomplicated infections IM or IV Injection From100 to125 mg/kg daily may be given; usual doses are 2 g every 6 or 8 hours, or 4 g every 12 hours, intravenously, or 2 g every 8 or 12 hours intramuscularly.
4 Uncomplicated gonorrhoea IM 2 gm Injection It is treated by a single intramuscular dose of 2 g. Probenecid 1 g may be given orally 30 minutes before the injection.
5 Prophylaxis of infection For prophylaxis of infection during surgery; given 2 g just before the procedure, or when the umbilical cord is clamped in caesarean section, followed by at least 2 doses of 2 g at intervals of 4 or 6 hours within 24 hours of the procedure, may be given.

Ref :-  Book : Martindale    Page : 340   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Mild to moderate infections i.v/i.m Injection

Ref :- Book : Martindale    Page : 340   Edition : 38  
►  Side Effect : Rashes, Nausea, Vomiting, Diarrhea
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 615   Edition : 3.  

►  Drug Interaction : Drug interaction of Piperacillin is with Anticoagulant , ,  Tetracycline , Chloramphenicol , Warfarin
Ref :-   Book : Martindale    Page : 230, 340   Edition : 38.   Martindale    Page : 232, 343, 1566, 340, 827, 2243   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  The possibility of a prolonged bleeding time after oral treatment with a broad-spectrum drug like piperacillin should be borne in mind in patients receiving anticoagulants eg warfarin. Piperacillin may also interact with bacteriostatic antibacterials, such as chloramphenicol or tetracyclines, and may be incompatible in vitro with other drugs, including some other antibacterials.
Ref :-   Book : Martindale    Page : 230,340   Edition : 38.  


►  Contraindication : If patient is hypersensitive to penecillins, Intrathecal route, Skin contact
Ref :-   Book : Martindale    Page : 229,340   Edition : 38.  
  ►  Mechanism of Action :   Piperacillin inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Piperacillin is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies.
Ref :-   Book : Martindale    Page : 373   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Alliin and Allicin have Antibiotic effect --- (Duke, J. & Duke, J. (2002). Handbook of medicinal herbs. Boca Raton, FL: CRC Press. )

  •   ►  URL --
  • https://books.google.co.in/books?id=vPTLBQAAQBAJ&printsec=frontcover&dq=Duke .
  • +J.+%26+Duke .
  • +J.+(2002).+Handbook+of+medicinal+herbs.+Boca+Raton .
  • +FL:+CRC+Press.&hl=en&sa=X&redir_esc=y#v=onepage&q=Duke%2C%20J.%20%26%20Duke%2C%20J. .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Biliary
    Ref :-   Book : Martindale    Page : 343   Edition : 37.   Martindale    Page : 341   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   about 1 hours but is prolonged in neonates,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 341   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   After a 2 g dose: 30 ,    Max value :-   50 minutes.  
    Ref :-   Book : Martindale    Page : 341   Edition : 38.