Piperacillin is a Medicine belongs to PENICILLINS group whose information about Brand can be referenced from   Book : Harrison's principles of internal medicine    Page : 344   Edition : 37, Martindale    Page : 344   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Pipracil,Pipracil,Pipracil,Microtaz

  ►  Strength : Injection with 2  gm, Injection with 3  gm, Injection with 4  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM,
Reference :-   Book : Martindale    Page : 343   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Serious or complicated infections IV 200 300 mg/kg Injection Given daily in divided doses.
2 Life-threatening infections IV 16 gm Injection Those caused by Pseudomonas or Klebsiella spp.; dose given daily.
3 Mild or uncomplicated infections IV 2 gm Injection t.i.d/q.i.d
4 Uncomplicated gonorrhoea IM 2 gm Injection Given with probenecid.
5 Prophylaxis of infection parenteral 2 gm For prophylaxis of infection during surgery; given just before the procedure, or when the umbilical cord is clamped in caesarean section.

Ref :-  Book : Martindale    Page : 344   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Mild to moderate infections 1 Month <1 Month i.v/i.m 100 150 mg/kg Injection
2 Severe infections 1 Month <1 Month i.v/i.m 200 300 mg/kg Injection
3 Infections caused by susceptible organisms >7 Day >2 150 mg/kg
4 Infections caused by susceptible organisms <7 Day <2 300 mg/kg

Ref :- Book : Martindale    Page : 344   Edition : 37,
►  Side Effect : NA

►  Drug Interaction : Drug interaction of Piperacillin is with Probenecid , Tetracycline , Ropinirole , Vecuronium Bromide , Voglibose , Methotrexate,
Ref :-   Book : Martindale    Page : 232, 343, 1566, 340, 827, 2243   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid prolongs the half-life of Piperacillin by competing with it for renal tubular secretion and may be used therapeutically for this purpose. The possibility of a prolonged bleeding time after oral treatment with a broad-spectrum drug like piperacillin should be borne in mind in patients receiving anticoagulants. Antagonism has been reported to occur with some bacteriostatic drugs, such as chloramphenicol or tetracyclines, that interfere with active bacterial growth necessary for piperacillin to achieve its effect. And both enhancement and antagonism of its activity have been demonstrated for beta-lactam combinations. It is reported to prolong the action of competitive muscle relaxants such as vecuronium. Piperacillin as other penicillins may markedly decrease the clearance of methotrexate given intravenously for treatment of neoplasms. Piperacillin may be responsible like ampicillin to decrease oral contraceptive efficacy. Some studies have pointed to interference with intestinal flora involved in enterohepatic circulation of oestrogens as being a likely mechanism for this interaction.,
Ref :-   Book : Martindale    Page : 232,343   Edition : 37,


►  Contraindication : Hypersensitivity, Allergy, Jarisch-Herxheimer reaction, penicillins,
Ref :-   Book : Martindale    Page : 232,235   Edition : 37,
  ►  Mechanism of Action :   Piperacillin inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Piperacillin is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies. Tazobactum is a penicillanic acid sulfone derivative with betalactamase inhibitory properties and therefore has the potential to enhance the activity of beta-lactam antibacterials against betalactamase- producing bacteria. ,
Ref :-   Book : Martindale    Page : 373   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Alliin and Allicin have Antibiotic effect --- (Duke, J. & Duke, J. (2002). Handbook of medicinal herbs. Boca Raton, FL: CRC Press. )

  •   ►  URL -- https://books.google.co.in/books?id=vPTLBQAAQBAJ&printsec=frontcover&dq=Duke, +J.+%26+Duke, +J.+(2002).+Handbook+of+medicinal+herbs.+Boca+Raton, +FL:+CRC+Press.&hl=en&sa=X&redir_esc=y#v=onepage&q=Duke%2C%20J.%20%26%20Duke%2C%20J.,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN K with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 343   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 343   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   0.83 hours,
    Ref :-   Book : Martindale    Page : 343   Edition : 38,