Piperacillin and tazobactum is a Medicine belongs to PENICILLINS group whose information about Brand can be referenced from   Book : Martindale    Page : 344   Edition : 37,

  ►   Brandname : Tazocin,Zosyn

  ►  Strength : Injection with 2  gm, Injection with 3  gm, Injection with 4  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 344   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Bacterial infections IV 4.5 gm Injection q.i.d. In case of neutropenic patients.
2 Nosocomial pnemonia IV 4.5 gm Injection q.i.d.
3 Severe infections IV 4.5 gm Injection q.i.d.
4 Dosing In Obesity: 6.75 gm IV over 4 hours and dosed every 8 hours. No data for patient with impaired renal function. Ref: The Sanford Guide To Antimicrobial Therapy, pg 232 ed. 47th

Ref :-  Book : Martindale    Page : 340   Edition : 38,    Page :    Edition : ,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hospital-acquired pneumonia >1 Day >28 Day IV infusion 90 mg/kg Injection t.i.d.
2 Hospital-acquired pneumonia 1 Month 12 Year IV infusion 90 mg/kg Injection t.i.d/q.i.d
3 Hospital-acquired pneumonia <12 Year IV infusion 4.5 gm Injection t.i.d.
4 Septicaemia >1 Day >28 Day IV infusion 90 mg/kg Injection t.i.d.
5 Septicaemia 1 Month 12 Year IV infusion 90 mg/kg Injection t.i.d/q.i.d
6 Septicaemia <12 Year IV infusion 4.5 gm Injection t.i.d.
7 Complicated urinary tract infection >1 Day >28 Day IV infusion 90 mg/kg Injection t.i.d.
8 Complicated urinary tract infection 1 Month 12 Year IV infusion 90 mg/kg Injection t.i.d/q.i.d
9 Complicated urinary tract infection <12 Year IV infusion 4.5 gm Injection t.i.d.
10 Complicated Skin and soft tissue infections >1 Day >28 Day IV infusion 90 mg/kg Injection t.i.d.
11 Complicated Skin and soft tissue infections 1 Month 12 Year IV infusion 90 mg/kg Injection t.i.d/q.i.d
12 Complicated Skin and soft tissue infections <12 Year IV infusion 4.5 gm Injection t.i.d.

Ref :- Book : Martindale    Page : 340   Edition : 38,
►  Side Effect : prolongation of bleeding time, hypersensitivity reactions, allergic reaction, Skin rashes, pain at the injection site, phlebitis, electrolyte disturbances, hypokalaemia, hypernatraemia, renal impairment, Nephropathy, interstitial nephritis,
Ref :-   Book : Martindale    Page : 232,235,343   Edition : 38,

►  Drug Interaction : Drug interaction of Piperacillin and tazobactum is with Probenecid , Ropinirole , Vecuronium Bromide , Voglibose , Methotrexate,
Ref :-   Book : Martindale    Page : 232, 343, 1566, (340, 827, 2243   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  NA


►  Contraindication : Hypersensitivity, Allergy, penicillins, Jarisch-Herxheimer reaction,
Ref :-   Book : Martindale    Page : 232,235   Edition : 37,
  ►  Mechanism of Action :   NA

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathwayAnother pathway, Red algae with Another pathwayAnother pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 343,369   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA