Piperacillin and tazobactum is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 341   Edition : 38  

  ►   Brandname : Adzopip, Baclin,Tazocin, PiperTaz, Tazobac, An Di Tai,Zosyn
  ►  Strength : Injection with 2 gm.  Injection with 3 gm.  Injection with 4 gm. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Martindale    Page : 344   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Bacterial infections IV 4.5 gm Injection q.i.d. Infections in neutropenic patients.
2 Nosocomial pnemonia IV 4.5 gm Injection q.i.d.
3 Severe infections IV 4.5 gm Injection q.i.d.
4 Dosing In Obesity: 6.75 gm IV over 4 hours and dosed every 8 hours. No data for patient with impaired renal function. Ref: The Sanford Guide To Antimicrobial Therapy, pg 232 ed. 47th

Ref :-  Book : Martindale    Page : 340   Edition : 38      Page :    Edition :   



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hospital-acquired pneumonia IV infusion Injection
2 Septicaemia IV infusion Injection
3 Complicated urinary tract infection IV infusion Injection
4 Complicated Skin and soft tissue infections IV infusion Injection
5 Neutropenia IV infusion Injection
6 Complicated intraabdominal infections caused by susceptible organisms IV infusion Injection

Ref :- Book : Martindale    Page : 340   Edition : 38  
►  Side Effect : Rashes, Vomiting, Nausea, Diarrhea
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 615   Edition : 3.  

►  Drug Interaction : Drug interaction of Piperacillin and tazobactum is with Anticoagulant , ,  Warfarin , Chloramphenicol , Tetracycline
Ref :-   Book : Martindale    Page : 230,340   Edition : 38.   Martindale    Page : 230, 340   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  The possibility of a prolonged bleeding time after oral treatment with a broad-spectrum drug like piperacillin should be borne in mind in patients receiving anticoagulants eg warfarin. Piperacillin may also interact with bacteriostatic antibacterials, such as chloramphenicol or tetracyclines, and may be incompatible in vitro with other drugs, including some other antibacterials.
Ref :-   Book : Martindale    Page : 230,340   Edition : 38.  


►  Contraindication : If patient is hypersensitive to penecillins, Intrathecal route, Skin contact
Ref :-   Book : Martindale    Page : 229,340   Edition : 38.  
  ►  Mechanism of Action :   Piperacillin inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Piperacillin is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies. Tazobactum is a penicillanic acid sulfone derivative with betalactamase inhibitory properties and therefore has the potential to enhance the activity of beta-lactam antibacterials against betalactamase- producing bacteria.
Ref :-   Book : Martindale    Page : 373   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathwayAnother pathway.   Red algae with Another pathwayAnother pathway.  

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .
  • http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy .
  • +C.+K.+Kokate .
  • +A.P.+Purohit .
  • +S.B.+Gokhale .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Biliary
    Ref :-   Book : Martindale    Page : 341   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   About 1 hours but is prolonged in neonates,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 341   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   After a 2 g dose: 30 ,    Max value :-   50 minutes.  
    Ref :-   Book : Martindale    Page : 341   Edition : 38.