Piperaquine is a Medicine belongs to Antimalarials group whose information about Brand can be referenced from   Book : Martindale    Page : 660   Edition : 38      Page :   Edition :   

  ►   Brandname : An Li Kang, Eurartesim, Synriam
  ►  Strength : Tablet with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 660   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 660   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info

Ref :-  Book :

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Treatment of acute uncomplicated malaria caused by P. falciparum Oral Tablet

Ref :- Book : Martindale    Page : 659   Edition : 38  
►  Side Effect : Dizziness, Headache, Nausea, Vomiting, Abdominal pain, Commonly reported adverse effects with the fixed-dose combination of piperaquine and artenimol are anemia, Asthenia, Pyrexia
Ref :-   Book : Martindale    Page : 660   Edition : 38.  

►  Drug Interaction : Drug interaction of Piperaquine is with , , ,  Paracetamol , Theophylline
Ref :-   Book : Martindale    Page : 660   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Piperaquine is metabolised by the cytochrome P450 isoenzyme CYP3A4 and to a lesser extent by CYP2C19 and CYP2C9. It is an inhibitor of the CYP3A4 and CYP2C19 isoenzymes and may inhibit the metabolism of other drugs that are metabolised by this route; it also has the potential to increase the rate of metabolism for CYP2E1 substrates such as paracetamol and theophylline. Drugs that inhibit CYP3A4 may increase plasma conc. of piperaquine and exacerbate the effects of QTc prolongation.
Ref :-   Book : Martindale    Page : 660   Edition : 38.  

►  Contraindication : The fixed-dose combination of piperaquine and artenimol is contraindicated in those with a family history of sudden death, Symptomatic cardiac arrhythmia, Severe hypertension, left ventricular hypertrophy, Congestive heart failure, Congenital prolongation QTc interval, Those with electrolyte disturbances
Ref :-   Book : Martindale    Page : 660   Edition : 38.  
  ►  Mechanism of Action :   The mechanisms by which ACTs exert their antimalarial activity remain contentious. Nevertheless, most studies concur that the activity of artemisinin and its potent derivatives results from reductive scission of the peroxide bridge by reduced heme-iron, which is produced inside the highly acidic digestive vacuole (DV) of the parasite as it digests hemoglobin. In addition to the formation of potentially toxic heme-adducts, activated artemisinin (for which the site of action remains unclear) might in turn generate free radicals that alkylate and oxidize proteins and possibly lipids in parasitized erythrocytes.
Ref :-   Book : Martindale    Page : 1395   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   elimination half-life of about 22 days in adults and 20 days in children.,    Max value :-   NA
Ref :-   Book : Martindale    Page : 660   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   5 hours after an oral dose.,    Max value :-   NA
Ref :-   Book : Martindale    Page : 660   Edition : 38.