Piperazine is a Medicine belongs to Antihelminthic Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 164   Edition : 38  

  ►   Brandname : Avizine
  ►  Strength : Syrup with .  Tablet with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 164   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 161   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Ascariasis A single dose, repeated once after 14 days is used; In adults and children over 12 years of age, a dose equivalent to 4.5 g of piperazine is given orally.
2 Enterobiasis Oral o.d. Piperazine has been given for 7 days. A second course after a 7-day interval may be required. Adults and children over 12 years of age, are given the dose equivalent of 2.25 g of the hydrate once daily.

Ref :-  Book : Martindale    Page : 163   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Ascariasis Oral
2 Enterobiasis Oral

Ref :- Book : Martindale    Page : 163   Edition : 38  
►  Side Effect : Dizziness, Gastrointestinal disturbances
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 648   Edition : 3.   Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 648   Edition : `3.      Page :    Edition : .  

►  Drug Interaction : Drug interaction of Piperazine is with Pyrantel- pamoate
Ref :-   Book : Martindale    Page : 161   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  The anthelmintic effects of piperazine and pyrantel may be antagonised when the two compounds are used together
Ref :-   Book : Martindale    Page : 161   Edition : 37.  


►  Contraindication : Epilepsy, Avoided or given with extreme caution in hepatic impairment, Severe renal impairment
Ref :-   Book : Martindale    Page : 163   Edition : 38.  
  ►  Mechanism of Action :   The predominant effect of piperazine on Ascaris is a flaccid paralysis that results in expulsion of the worm by peristalsis. Affected worms recover if incubated in drug-free medium. Piperazine acts as a GABA-receptor agonist. By increasing chloride ion conductance of Ascaris muscle membrane, the drug produces hyperpolarization and reduced excitability that leads to muscle relaxation and flaccid paralysis.
Ref :-   Book : Goodman    Page : 1458   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 164   Edition : 38.  

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA