Piperazine is a Medicine belongs to Antihelminthic Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 161   Edition : 37,

  ►   Brandname : Pripsen

  ►  Strength : Elixir with nf  ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 161   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Ascariasis Oral 4.5 gm A single dose, repeated once after 14 days is used; A dose equivalent to 4.5 g is given.
2 Enterobiasis Oral 2.25 gm o.d. A dose equivalent to 2.25 g is given. Drug given for 7 days.

Ref :-  Book : Martindale    Page : 161   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Ascariasis <12 Year Oral 4.5 gm
2 Ascariasis 9 Year 12 Year Oral 3.75 gm
3 Ascariasis 6 Year 8 Year Oral 3 gm
4 Ascariasis 4 Year 5 Year Oral 2.25 gm Syrup
5 Ascariasis 1 Year 3 Year Oral 1.5 gm Syrup
6 Ascariasis >1 Year Oral 120 mg/kg
7 Enterobiasis <12 Year Oral 2.25 gm Tablet o.d.
8 Enterobiasis 7 Year 12 Year Oral 1.5 gm Syrup
9 Enterobiasis 4 Year 6 Year Oral 1.125 gm Syrup
10 Enterobiasis 1 Year 3 Year Oral 750 mg Syrup
11 Enterobiasis >1 Year Oral 45 75 mg/kg

Ref :- Book : Martindale    Page : 161   Edition : 37,
►  Side Effect : nausea, vomiting, diarrhea, abdominal pain, Skin rashes, headache, Urticaria, Severe neurotoxicity, ECG abnormalities, Somnolence, Dizziness, nystagmus, muscular incoordination, weakness, ataxia, paraesthesia, myoclonic contractions, choreiform movements, tremor, convulsion, loss of reflexes, Blurred Vision, cataract formation, hypersensitivity reactions, bronchospasm, Stevens-Johnson syndrome, angioedema,
Ref :-   Book : Martindale    Page : 161   Edition : 37,

►  Drug Interaction : Drug interaction of Piperazine is with Pyrantel- pamoate , Phenothiazine, Chlorpromazine ,
Ref :-   Book : Martindale    Page : 161   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The anthelmintic effects of piperazine and pyrantel may be antagonised when the two compounds are used together,
Ref :-   Book : Martindale    Page : 161   Edition : 37,


►  Contraindication : Epilepsy, hepatic impairment, renal impairment, pregnancy,
Ref :-   Book : Martindale    Page : 161   Edition : 37,
  ►  Mechanism of Action :   The predominant effect of piperazine on Ascaris is a flaccid paralysis that results in expulsion of the worm by peristalsis. Affected worms recover if incubated in drug-free medium. Piperazine acts as a GABA-receptor agonist. By increasing chloride ion conductance of Ascaris muscle membrane, the drug produces hyperpolarization and reduced excitability that leads to muscle relaxation and flaccid paralysis. ,
Ref :-   Book : Goodman    Page : 1458   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 161   Edition : 37,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA