Piroxicam is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 123   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Brexic,Dolokam,Dolonex,Feldene,Dolonex DT

  ►  Strength : Capsule with 10  mg, Capsule with 20  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, rectal,
Reference :-   Book : Martindale    Page : 122   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Rheumatic disorders Oral 20 mg Capsule o.d.
2 Painful conditions Topical 0.5 % Gel t.i.d/q.i.d
3 Inflammatory conditions Topical 0.5 % Gel t.i.d/q.i.d

Ref :-  Book : Martindale    Page : 123   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Juvenile idiopathic arthritis =<6 Year >15 Oral 5 mg o.d.
2 Juvenile idiopathic arthiritis =<6 Year 16-25 Oral 10 mg o.d.
3 Juvenile idiopathic arthiritis =<6 Year =<46 Oral 20 mg Capsule o.d.

Ref :- Book : Martindale    Page : 123   Edition : 37,
►  Side Effect : gastrointestinal disturbance, nausea, diarrhea, headache, vertigo, Dizziness, Nervousness, tinnitus, anaemia, thrombocytopenia, neutropenia, eosinophilia, agranulocytosis, local irritation, bleeding, tissue damage at the site of injection,
Ref :-   Book : Martindale    Page : 100,123   Edition : 37,

►  Drug Interaction : Drug interaction of Piroxicam is with possibly,  Ropinirole , Azapropazone, Phenylbutazone, Felbamate, Methotrexate, Cabergoline , Sertraline, Cyclosporine , Tacrolimus , Tenecteplase , Phenytoin , , Trifluoperazine , Pramlintide , Rizatriptan , Clopidogrel , Ticlopidine , Iloprost , Erlotinib, Sibutramine, Zonisamide , Probenecid , Pentoxifylline , Ritonavir, Mifepristone , Aspirin,
Ref :-   Book : Martindale    Page : 103, 122, 123   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Interactions involving NSAIDs include enhancement of the effects of oral anticoagulants (especially by azapropazone and phenylbutazone) and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides. The risk of nephrotoxicity may be increased if given with ACE inhibitors, ciclosporin, tacrolimus, or diuretics. There may also be an increased risk of hyperkalaemia with ACE inhibitors and some diuretics, including potassiumsparing diuretics. The antihypertensive effects of some antihypertensives including ACE inhibitors, beta blockers, and diuretics may be reduced. NSAIDs may increase the effects of phenytoin and sulfonylurea antidiabetics. The risk of gastrointestinal bleeding and ulceration associated with NSAIDs is increased when used with corticosteroids, the SSRIs, the SNRI venlafaxine, the antiplatelets clopidogrel and ticlopidine, iloprost, erlotinib, sibutramine, or, possibly, alcohol, bisphosphonates, or pentoxifylline. Licensed product information for mifepristone advises of a theoretical risk that prostaglandin synthetase inhibition by NSAIDs or aspirin may alter the efficacy of mifepristone. Use of aspirin with piroxicam results in decreased plasma concentrations of piroxicam. Piroxicam with ritonavir may result in increased plasma concentrations of piroxicam and an increased risk of toxicity.,
Ref :-   Book :    Page : 103,122,123   Edition : 37,


►  Contraindication : intracranial bleeding, Coagulation defect, asthma, urticaria, anaphylactic reactions, renal insufficiency, porphyria.,
Ref :-   Book : Martindale    Page : 122   Edition : 37,
  ►  Mechanism of Action :   Inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), decreasing the biosynthesis of downstream eicosanoids and thereby limiting the inflammatory response,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 761   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- BETANIN HCL with Increase the risk of stomach bleeding, FOLIC ACID with It block the activity of enzymes that depend on folic acid ., LITHIUM with It increase the level of lithium and possibly resulting in unwanted side effects such as diarrhea , nausea , muscle weakness , and lack of coordination ., WILLOW BARK with Taking willow bark with this drug significantly lowers blood level of piroxicam and increases the potential for adverse side effects .,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 123   Edition : 37,


    ►    Plasma Half-life :   Min value :-   50 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 123   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   7 hours,
    Ref :-   Book : Martindale    Page : 123   Edition : 37,