Pneumococcal vaccine is a Medicine belongs to vaccine group whose information about Brand can be referenced from   Book : Martindale    Page : 2410   Edition : 38  

  ►   Brandname : Pneumovax 23, Pneumovax II, Prevenar 13, Prevenar, Hui Yi Kang
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2410   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : s.c/ i.m
Reference :-   Book : Martindale    Page : 2410   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Active immunization in patients at increased risk from infection with types of streptococcus pneumoniae contained in the vaccine parenteral Injection An antibody response develops by the third week, and usually lasts about 5 years. The antibody response is less reliable and declines more rapidly in young children and persons with impaired immune function. A single dose of 0.5 mL of the 23-valent vaccine, containing 25 micrograms of each of the 23 polysaccharide types, is given to at-risk adults by intramuscular injection (or subcutaneously if there are bleeding disorders). The vaccine should be given at least 2 weeks (but preferably 4 to 6 weeks) before treatment. Revaccination is not generally recommended except, after 5 years, in patients likely to have rapidly declining antibody concentrations (for example, those with asplenia or splenic dysfunction and those with nephrotic syndrome). The 7 and 13-valent pneumococcal conjugate vaccine is given by intramuscular injection. A single dose of a 23-valent pneumococcal polysaccharide vaccine (PPV) is given to all adults 65 years and over.

Ref :-  Book : Martindale    Page : 2410   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Active immunization in patients at increased risk from infection with types of streptococcus pneumoniae contained in the vaccine
2 Vaccination schedule for the clinical risk groups

Ref :- Book : Martindale    Page : 2410   Edition : 38  
►  Side Effect : Injection of a vaccine may be followed by a local reaction, possibly with inflammation and lymphangitis, An induration or sterile abscess may develop at the injection site, Fever, Headache, Malaise, Hypersensitivity reactions, , Revaccination of adults is not routinely recommended because of the increased incidence and severity of adverse reactions
Ref :-   Book : Martindale    Page : 2375,2410   Edition : 38.      Page :    Edition : .  

►  Drug Interaction : Drug interaction of Pneumococcal vaccine is with , Antineoplastic , Corticosteroids, ,  NA

  ►    Mechanism of Drug Drug Interaction :  The ability of vaccines to induce an immune response can be influenced by the recent use of other vaccines or immunoglobulins. Live vaccines should either be given simultaneously (but at different sites) or an interval of at least 3 weeks allowed between them. Live vaccines should normally be given at least 3 weeks before or at least 3 months after the use of immunoglobulin. However, travellers should receive appropriate vaccines regardless of these limitations if time is short. Patients receiving immunosuppressant therapy, including antineoplastics or therapeutic doses of corticosteroids, may also display a reduced response to vaccines and deferral of immunisation is advised. Any agent that is active against the bacterial or viral strain present in the vaccine may interfere with development of a protective immune response but treatment with antibacterials is not a contra-indication to immunisation.
Ref :-   Book : Martindale    Page : 2375,2410   Edition : 38.  


►  Contraindication : In patients with Hodgkin’s disease the use of pneumococcal vaccines is not recommended in those who have received extensive chemotherapy or nodal irradiation, All vaccines are contra-indicated in those who have had a previous confirmed anaphylactic reaction to a previous dose of a vaccine containing the same antigens or a confirmed anaphylactic reaction to another component contained in the relevant vaccine, Some vaccines are prepared in egg cultures and are contra-indicated in persons with a confirmed anaphylactic reaction to egg, Live vaccines are contra-indicated in immunosuppressed patients
Ref :-   Book : Martindale    Page : 2375,2410   Edition : 38.  
  ►  Mechanism of Action :   Of the many serotypes of Streptococcus pneumoniae the 23 from which antigens are obtained for the most commonly available pneumococcal vaccine are considered to cause up to 96% of pneumococcal disease. Pneumococcal vaccines are used for active immunisation in those at increased risk from infection with the types of Streptococcus pneumoniae contained in the vaccine. Pneumococcal vaccines may be in the form of an unconjugated 23-valent polysaccharide vaccine or as a conjugate vaccine containing 7 serotypes.
Ref :-   Book : Martindale    Page : 2410   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Astragalus ( Huang -Qi ) with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Triterpene Gycosides stimulates macrophages, promotes antibody formation and increases T-Lymphocyte Proliferation --- (Duke, J. & Duke, J. (2002). Handbook of medicinal herbs. Boca Raton, FL: CRC Press. )

  •   ►  URL --
  • https://books.google.co.in/books?id=vPTLBQAAQBAJ&printsec=frontcover&dq=Duke .
  • +J.+%26+Duke .
  • +J.+(2002).+Handbook+of+medicinal+herbs.+Boca+Raton .
  • +FL:+CRC+Press.&hl=en&sa=X&redir_esc=y#v=onepage&q=Duke%2C%20J.%20%26%20Duke%2C%20J.%20(2002).%20Handbook%20of%20medicinal%20herbs. .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA