Polymyxin B is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 343   Edition : 38  

  ►   Brandname : Aerosporin
  ►  Strength : Injection with 500000 units.  Ophthalmic with 500000 units per vial. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 898   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Topical, intrathecal
Reference :-   Book : Martindale    Page : 342   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Skin, ear, and eye infections due to susceptible organisms Topical For topical application polymyxin B is usually available as a 0.1% solution or ointment (10 000 units per mL or per g respectively) combined with other drugs.
2 Infections caused by susceptible Gram-negative organisms Injection Treatment of infections due to susceptible Gram-negative bacteria, especially Pseudomonas aeruginosa. Intravenous doses range from 15 000 to 25 000 units/kg daily, by infusion and may be given every 12 hours. The intramuscular route has also been used despite the severe pain which may be associated with it; doses range from 25 000 to 30 000 units/kg daily, and may be given every 4 or 6 hours.
3 Meningeal infection intrathecal Intrathecal doses of 50 000 units may be given once daily for 3 to 4 days, then on alternate days for at least 2 weeks after the CSF cultures become negative.
4 Eye infections Injection For subconjunctival injection, doses of up to 100 000 units daily may be used for infections of the cornea and conjunctiva.

Ref :-  Book : Martindale    Page : 342   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Infections caused by susceptible organisms
2 Meningeal infection

Ref :- Book : Martindale    Page : 342   Edition : 38   Martindale    Page : 342   Edition : 38`  
►  Side Effect : Hypersensitization is uncommon with topical application, Nephrotoxic, Neuromuscular blockade, Muscle weakness, Paresthesia, Vertigo, Slurred speech
Ref :-   Book : Goodman    Page : 1539   Edition : 12.   Martindale    Page : 1539   Edition : 12.  

►  Drug Interaction : Drug interaction of Polymyxin B is with Neuromuscular blocking drugs , , Nephrotoxic drugs, Aminoglycoside antibiotic ,  NA

  ►    Mechanism of Drug Drug Interaction :  Polymyxins may enhance the action of neuromuscular blockers possibly resulting in respiratory depression and apnoea, and concurrent use should be avoided. Additive neurotoxicity and/or nephrotoxicity may occur if polymyxins are given with other potentially neurotoxic and/or nephrotoxic drugs including aminoglycosides; concurrent use should also be avoided.
Ref :-   Book : Martindale    Page : 342   Edition : 38.  


►  Contraindication : Patients with a history of hypersensitivity to any of the group, Ear drops containing polymyxins should not be used in patients with perforated ear drums, Topical application to large areas of skin should be avoided
Ref :-   Book : Martindale    Page : 343   Edition : 38.  
  ►  Mechanism of Action :   Polymyxin B and the other polymyxin antibacterials act primarily by binding to membrane phospholipids and disrupting the bacterial cytoplasmic membrane. Polymyxin B has a bactericidal action on most Gramnegative bacilli except Proteus spp. It is particularly effective against Pseudomonas aeruginosa.
Ref :-   Book : Martindale    Page : 342   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 343   Edition : 38.  

►    Plasma Half-life :   Min value :-   after i.m injection usually occur within 2 hours, but are variable,    Max value :-   NA
Ref :-   Book : Martindale    Page : 342   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   serum half-life of about 6 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 342   Edition : 38.