Posaconazole is a Medicine belongs to Antifungal group whose information about Brand can be referenced from   Book : Martindale    Page : 593   Edition : 37,

  ►   Brandname : Noxafil

  ►  Strength : Suspension with 40  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oropharyngeal candidiasis Oral 200 mg Suspension This a loading dose given on the first day, followed by 100 mg daily for 13 days.
2 Refractory invasive systemic fungal infection Oral 400 mg Suspension b.d.

Ref :-  Book : Martindale    Page : 592   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : headache, nausea, abdominal pain, anorexia, asthenia, back pain, diarrhea, dyspepsia, Dizziness, dry mouth, dry skin, fatigue, fever, Flatulence, hot flashes, insomnia, neutropenia, paraesthesia, pruritus, rash, Somnolence, vomiting, increased liver enzyme values, hepatotoxicity, Stevens-Johnson syndrome,
Ref :-   Book : Martindale    Page : 592   Edition : 37,

►  Drug Interaction : Drug interaction of Posaconazole is with Clarithromycin , Erythromycin , Cyclosporine , Verapamil , Rifabutin , Phenytoin , Rifampicin , Carbamazapine , Primidone , Phenobarbital , Cimetidine , Astemizole, Cisapride , Halofantrine, Pimozide , Quinidine , Terfenadine, Ergotamine, dihydroergotamine, Atorvastatin , Lovastatin , Simvastatin ,
Ref :-   Book : Martindale    Page : 592   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Posaconazole is metabolised by the uridine diphosphate glucuronosyltransferase UGT1A4, and is a substrate for p-glycoprotein. The use of drugs that either inhibit (for example clarithromycin, erythromycin, ciclosporin, and verapamil) or induce enzymes in this pathway may increase or decrease plasma-posaconazole concentrations, respectively. Rifabutin and phenytoin have been shown to decrease plasma-posaconazole concentrations and a similar effect may be expected with rifampicin, carbamazepine, primidone, and phenobarbital. Concentration of posaconazole are reduced by cimetidine possibly due to reduced absorption of posaconazole as a result of decreased acid production and reduced posaconazole concentrations may also be expected with other H2-antagonists and proton pump inhibitors. Posaconazole is an inhibitor of the cytochrome P450 isoenzyme CYP3A4. Use with ergot alkaloids is also contra-indicated because of the possible risk of ergotism. ,
Ref :-   Book : Martindale    Page : 592   Edition : 37,


►  Contraindication : Proarrhythmic condition, hepatic dysfunction,
Ref :-   Book : Martindale    Page : 592   Edition : 37,
  ►  Mechanism of Action :   Inhibit ultimate conversion of lanosterol to ergosterol by inhibiting 14α-sterol demethylase; the resulting decrease in ergosterol synthesis and accumulation of 14α-methyl sterols disrupt the tightly packed acyl chains of the phospholipids in the fungal membrane. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 627   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Renal,
Ref :-   Book : Martindale    Page : 292`   Edition : 37,


►    Plasma Half-life :
  Min value :-   35 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 592   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   5 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 592   Edition : 37,