Potassium/Potassium Salts is a Medicine belongs to Electrolytes group whose information about Brand can be referenced from   Book : Martindale    Page : 1832   Edition : 37      Page :   Edition :    Martindale    Page : 1794   Edition : 38  

  ►   Brandname : Keylyte, Potklor, Kay-Cee-L, Slow-K, Cena-K, Gen-K, K + 10, Duro-K,Kalinor-retard P, ORS, Di Jia
  ►  Strength : Oral solution with .  Tablet with .  Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1794   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV
Reference :-   Book : Martindale    Page : 1831   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prevention of hypokalaemia Oral 50 mmol Potassium chloride is probably the most commonly used potassium salt. Other salts that are or have been used in the management of potassium deficiency include potassium ascorbate, potassium aspartate, potassium gluconate etc. Above max. dose is given daily and similar doses may be adequate in mild potassium deficiency. Patients with renal impairment should receive correspondingly lower doses.
2 Severe acute hypokalaemia IV infusion Injection This normally entails infusing a solution containing 20 mmol of potassium in 500 mL over 2 to 3 hours under ECG control. A recommended maximum dose is 2 to 3 mmol/kg of potassium in 24 hours. Adequate urine flow must be ensured and careful monitoring of plasma-potassium and other electrolyte concentrations is essential. Potassium chloride is the salt most commonly used and solutions intended for intravenous use that are in a concentrated form (such as 1.5 or 2 mmol/mL) must be diluted to the appropriate concentration before use. Potassium chloride is also available as premixed infusions with sodium chloride and/or glucose containing 10 to 40 mmol/litre of potassium.

Ref :-  Book : Martindale    Page : 1793   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Paresthesia of the extremities, Muscle weakness, Paralysis, Cardiac arrhythmia, heart block, Cardiac arrest, Confusion, Pain, Phlebitis, Nausea, Vomiting, Diarrhea, Abdominal cramp, Gastrointestinal ulceration, Haemorrhage, Perforation
Ref :-   Book : Martindale    Page : 1830   Edition : 37.  

►  Drug Interaction : Drug interaction of Potassium/Potassium Salts is with Piroxicam , Temazepam , Sertraline, Cyclosporine , Magnesium/Magnesium Sulphate, Magnesium/Magnesium Sulphate, Corticotropin
Ref :-   Book : Martindale    Page : 24, 103   Edition : 37.   Martindale    Page : 1831   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Potassium supplements should be used with caution, if at all, in patients receiving drugs that increase serumpotassium concentrations. These include potassiumsparing diuretics, ACE inhibitors, ciclosporin, and drugs that contain potassium such as the potassium salts of penicillin. Antimuscarinics delay gastric emptying and consequently may increase the risk of gastrointestinal adverse effects in patients receiving solid oral dosage forms of potassium.
Ref :-   Book : Martindale    Page : 1831   Edition : 37.  


►  Contraindication : , Cardiac disease, Hyperkalaemia, Dehydration, Pregnant women
Ref :-   Book :    Page :    Edition : .   Martindale    Page : 1830-1831   Edition : 37.  
  ►  Mechanism of Action :   Potassium is mainly an intracellular cation, primarily found in muscle; only about 2% is present in the extracellular fluid. It is essential for numerous metabolic and physiological processes including nerve conduction, muscle contraction, and acid–base regulation. A normal concentration of potassium in plasma is about 3.5 to 5.0 mmol/litre, but factors influencing transfer between intracellular and extracellular fluids such as acid–base disturbances can distort the relationship between plasma concentrations and total body stores.Treatment involves correcting any underlying disorder and replacement therapy with potassium salts. Oral potassium supplements are generally preferred but in severe hypokalaemia associated with cardiac arrhythmias, paralysis or diabetic ketoacidosis, parenteral therapy may be necessary. Potassium salts, usually potassium chloride, may be slowly to avoid causing hyperkalaemia and associated cardiac toxicity; plasma-potassium concentrations should be closely monitored and ECG monitoring may be required. The choice of salt for oral potassium replacement depends on co-existing acid–base and electrolyte disturbances.
Ref :-   Book : Martindale    Page : 1777,1793   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- SALT with Using large amount of salt inplace of potassium chloride is harmful ..   VITAMIN B12 with Reduces vit B 12 absortion..  

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf
    http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf

    ►   Route of Elimination :   Renal, Faecal
    Ref :-   Book : Martindale    Page : 1794   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA