Pralidoxime is a Medicine belongs to Chelators Antidotes and Antagonists group whose information about Brand can be referenced from   Book : Martindale    Page : 1572   Edition : 38,

  ►   Brandname : Aldopam,Neopam,Protopam

  ►  Strength : Injection with 1  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 127   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM, SC, Oral,
Reference :-   Book : Martindale    Page : 1572   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Organophosphorus poisoning IV 1 2 gm Injection
2 Antimyasthenic overdose IV infusion 1 2 gm Injection

Ref :-  Book : Martindale    Page : 1571   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Organophosphorus poisoning IV 1 2 gm Injection

Ref :- Book : Martindale    Page : 1571   Edition : 38,
►  Side Effect : drowsiness, Dizziness, nausea, tachycardia, headache, hyperventilation, muscular weakness, Impaired renal function, Increase in liver enzyme values, hypertension, laryngospasm, Muscle rigidity, transient neuromuscular blockade, disturbances of vision,
Ref :-   Book : Martindale    Page : 1571   Edition : 38,

►  Drug Interaction : Drug interaction of Pralidoxime is with Atropine ,
Ref :-   Book : Martindale    Page : 1571   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  When atropine and pralidoxime are given together, the signs of atropinisation may occur earlier than might be expected when atropine is used alone.,
Ref :-   Book : Martindale    Page : 1571   Edition : 38,


►  Contraindication : ,
Ref :-   Book :    Page :    Edition : ,
  ►  Mechanism of Action :   Pralidoxime is a cholinesterase reactivator. Pralidoxime acts principally to reactivate cholinesterase, restoring the enzymatic destruction of acetylcholine at the neuromuscular junction and relieving muscle paralysis,
Ref :-   Book : Martindale    Page : 1571   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 1572   Edition : 38,


►    Plasma Half-life :
  Min value :-   1 hours,    Max value :-   3 hours,
Ref :-   Book : Martindale    Page : 1572   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   0.83 hours,    Max value :-   0.25,
Ref :-   Book : Martindale    Page : 1572   Edition : 38,