Pralidoxime is a Medicine belongs to Chelators Antidotes and Antagonists group whose information about Brand can be referenced from   Book : Martindale    Page : 1572   Edition : 38  

  ►   Brandname : Aldopam, Neopam, Protopam
  ►  Strength : Injection with 1 gm. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 127   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM, SC, Oral
Reference :-   Book : Martindale    Page : 1572   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Organophosphorus poisoning IV 1 2 gm Injection
2 Antimyasthenic overdose IV infusion 1 2 gm Injection

Ref :-  Book : Martindale    Page : 1571   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Organophosphorus poisoning IV 1 2 gm Injection

Ref :- Book : Martindale    Page : 1571   Edition : 38  
►  Side Effect : Drowsiness, Dizziness, Nausea, Tachycardia, Headache, Hyperventilation, Muscular weakness, Impaired renal function, Increase in liver enzyme values, Hypertension, Laryngospasm, Muscle rigidity, Transient neuromuscular blockade, Disturbances of vision
Ref :-   Book : Martindale    Page : 1571   Edition : 38.  

►  Drug Interaction : Drug interaction of Pralidoxime is with Atropine
Ref :-   Book : Martindale    Page : 1571   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  When atropine and pralidoxime are given together, the signs of atropinisation may occur earlier than might be expected when atropine is used alone.
Ref :-   Book : Martindale    Page : 1571   Edition : 38.  


►  Contraindication :
Ref :-   Book :    Page :    Edition : .  
  ►  Mechanism of Action :   Pralidoxime is a cholinesterase reactivator. Pralidoxime acts principally to reactivate cholinesterase, restoring the enzymatic destruction of acetylcholine at the neuromuscular junction and relieving muscle paralysis
Ref :-   Book : Martindale    Page : 1571   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal
Ref :-   Book : Martindale    Page : 1572   Edition : 38.  

►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   3 hours.  
Ref :-   Book : Martindale    Page : 1572   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   0.83 hours,    Max value :-   0.25.  
Ref :-   Book : Martindale    Page : 1572   Edition : 38.