Pramlintide is a Medicine belongs to Amylin analogue/Endocrine Drug group whose information about Brand can be referenced from   Book : Martindale    Page : 496   Edition : 37,

  ►   Brandname : Symlin

  ►  Strength : Injection with 0.6  mg/ml, Injection with 1  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC,
Reference :-   Book : Martindale    Page : 496   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Type 2 diabetes mellitus SC 15 micrograms Injection Immediately before major meals.
2 Type 2 diabetes mellitus SC 60 micrograms Injection Immediately before major meals.

Ref :-  Book : Martindale    Page : 496   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Severe hypoglycaemia, nausea, vomiting, anorexia, headache,
Ref :-   Book : Martindale    Page : 496   Edition : 37,

►  Drug Interaction : Drug interaction of Pramlintide is with Potassium iodide ,
Ref :-   Book : Martindale    Page : 496   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Pramlintide has the potential to delay the absorption of oral medication; in cases where the rapid onset of action from an oral drug is critical, it should be given at least 1 hour before or 2 hours after pramlintide. Also, pramlintide may interfere with drugs given to alter gastrointestinal motility or absorption. Pramlintide increases the risk of insulin-induced hypoglycaemia. ,
Ref :-   Book : Martindale    Page : 496   Edition : 37,


►  Contraindication : gastroparesis,
Ref :-   Book : Martindale    Page : 496   Edition : 37,
  ►  Mechanism of Action :   Pramlintide is a synthetic analogue of amylin, a pancreatic peptide hormone thought to play a role in the regulation of glucose homoeostasis. with proline at positions 25 (alanine), 28 (serine), and 29 (serine). Pramlintide slows the rate of gastric emptying, prevents the postprandial rise in glucagon concentrations, and reduces appetite,
Ref :-   Book : Martindale    Page : 496   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 496   Edition : 37,


►    Plasma Half-life :
  Min value :-   0.8 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 496   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   0.33 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 496   Edition : 37,