Pravastatin is a Medicine belongs to group whose information about Brand can be referenced from   Book : Martindale    Page : 1509   Edition : 37,

  ►   Brandname : Pravator,Lipostat,Pravachol

  ►  Strength : Tablet with 10  mg, Tablet with 20  mg, Tablet with 40  mg, Tablet with 80  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 633   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1509   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hypercholesterolaemia Oral 10 40 mg Tablet o.d. At bedtime.
2 Hypercholesterolaemia Oral 20 mg Tablet o.d. In patients also taking ciclosporin.

Ref :-  Book : Martindale    Page : 1509   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hypercholesterolaemia 8 Year 13 Year Oral 10 20 mg Tablet o.d.
2 Hypercholesterolaemia 14 Year 18 Year Oral 10 40 mg Tablet o.d.

Ref :- Book : Martindale    Page : 1509   Edition : 37,
►  Side Effect : gastrointestinal disturbance, headache, Skin rashes, Dizziness, Blurred Vision, insomnia, Dysgeusia, hepatitis, Pancreatitis, hypersensitivity reactions, anaphylaxis, angioedema, myopathy, myalgia, muscle weakness,
Ref :-   Book : Martindale    Page : 1526   Edition : 37,

►  Drug Interaction : Drug interaction of Pravastatin is with Cyclosporine ,
Ref :-   Book : Martindale    Page : 1526   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Pravastatin is not significantly metabolised by the cytochrome P450 enzyme system and does not have the same interactions with enzyme inhibitors as simvastatin, although caution has been advised when such combinations are used. Increased plasma-pravastatin concentrations have been reported in some patients receiving ciclosporin and low doses should be used.,
Ref :-   Book : Martindale    Page : 1526   Edition : 37,


►  Contraindication : hepatic disease, Pregnant and lactating women,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 330   Edition : 3,
  ►  Mechanism of Action :   Inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis→LDL decreases up to 60%, HDl increases ̴10% Triglycerides decreases upto 40%. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 330   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor, LITHIUM with Increase in Nutrient Level, FOLIC ACID with Decrease in Nutrient Level, COQ10 with Decrease in Nutrient Level, VITAMIN A with Increase in Nutrient Level,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- COQ10 with Impairs coenzyme Q10 metabolism .,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1509   Edition : 37,


    ►    Plasma Half-life :   Min value :-   1.5 ,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1473   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1 ,    Max value :-   4 hours,
    Ref :-   Book : Goodman    Page : 896   Edition : 12,