Praziquantel is a Medicine belongs to Antihelminthic Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 165   Edition : 38  

  ►   Brandname : Cest,Cysticide, Biltricide, Cesol
  ►  Strength : Tablet with 600 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 946   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Basic & Clinical pharmacology    Page : 946   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Fluke infections Oral Doses in adults in the liver and lung fluke infections are 25 mg/kg three times daily for two days or a single dose of 40 mg/kg. Similar doses may be used in intestinal fluke infections.
2 Schistosomiasis Oral Tablet In the treatment of schistosomiasis it is given on one day as three doses of 20 mg/kg at intervals of 4 to 6 hours or it is given as a single dose of 40 to 60 mg/kg.
3 Tape Worm infections Oral Drug may be given as an oral single dose in the treatment of tapeworm infections in adults. For the treatment of Taenia saginata and T. solium infections the recommended dose is 5 to10 mg/kg, for Hymenolepis nana infections the dose is 15 to 25 mg/kg, and for Diphyllobothrium latum infections doses of 5 to 25 mg/kg have been suggested.
4 Neurocysticercosis Oral Tablet Praziquantel is used in adults in the treatment of neurocysticercosis in a dose of 50 mg/kg daily in 3 divided doses for 14 days. An alternative regimen of 3 doses of 25 mg/kg every 2 hours has been proposed.

Ref :-  Book : Martindale    Page : 164   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Neurocysticercosis Over 4 years Oral
2 Schistosomiasis Over 4 years Oral
3 Fluke infections Over 4 years Oral Tablet
4 Tape Worm infections Over 4 Year Oral

Ref :- Book : Martindale    Page : 164   Edition : 38  
►  Side Effect : Abdominal discomfort, Abdominal pain, Nausea, Diarrhea, Headache, Dizziness, Drowsiness, Malaise, Fever, pruritus, Urticaria, Rashes, Eosinophilia, Most patients with neurocysticercosis who are given praziquantel suffer CNS effects, including, Seizure, Intracranial hypertension, , Hyperthermia
Ref :-   Book : Martindale    Page : 162   Edition : 37.      Page :    Edition : .  

►  Drug Interaction : Drug interaction of Praziquantel is with Carbamazapine , Phenytoin , Cimetidine , Dexamethasone , Rifampicin , Erythromycin , Phenobarbital , Itraconazole , Ketoconazole
Ref :-   Book : Martindale    Page : 165   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Praziquantel is metabolised via various cytochrome P450 isoenzymes including CYP3A4 and therefore has the potential to interact with drugs that are inhibitors or inducers of such enzymes. Enzyme-inducing drugs such as carbamazepine, dexamethasone, phenobarbital, and phenytoin may decrease plasma conc. of praziquantel. Conversely, enzyme inhibitors such as cimetidine, erythromycin, itraconazole, and ketoconazole, may increase plasma conc. of praziquantel. Concomitant use of rifampicin and praziquantel should be avoided as rifampicin is a strong inducer of cytochrome P450 isoenzymes and may cause subtherapeutic concentrations of praziquantel. If treatment with praziquantel is essential rifampicin should be stopped 4 weeks before starting praziquantel; treatment with rifampicin can be restarted one day after finishing praziquantel therapy.
Ref :-   Book : Martindale    Page : 165   Edition : 38.  


►  Contraindication : Ocular or spinal cysticercosis, May cause dizziness or drowsiness and if affected they should not drive or operate machinery during or for 24 hours after treatment
Ref :-   Book : Martindale    Page : 165   Edition : 38.  
  ►  Mechanism of Action :   Praziquantel appears to increase the permeability of trematode and cestode cell membranes to calcium, resulting in paralysis, dislodgement, and death.
Ref :-   Book : Basic & Clinical pharmacology    Page : 944   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Myrrh i .e. stem of Commiphora molmlo with Another pathway.  

  ►  Pathway with its reference as follows :-
  • --- ( Pdr for herbal medicine. (2016) (4th ed., pp. 1-56363-361- 2). )

  •   ►  URL --
  • http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 162   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   1,    Max value :-   1.5 hours and that of the metabolites about 4 hours.  
    Ref :-   Book : Martindale    Page : 165   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   1 ,    Max value :-   4 hours.  
    Ref :-   Book : Martindale    Page : 165   Edition : 38.