Prazosin is a Medicine belongs to Antihypertensive Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 1511   Edition : 37,

  ►   Brandname : Minipress,Hypovase,Kentovase,Prazocip

  ►  Strength : Capsule with 1  mg, Capsule with 2  Mg, Capsule with 5  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1511   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 500 micrograms b.d/t.i.d For 3 to 7 days.
2 hypertension Oral 1 mg b.d/t.i.d
3 Raynaud’s syndrome Oral 500 micrograms b.d.
4 Benign prostatic hyperplasia Oral 500 micrograms b.d.
5 Heart failure Oral 500 micrograms Two to four times daily.

Ref :-  Book : Martindale    Page : 1511   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension Oral 0.05 0.1 mg/kg/day t.i.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1645   Edition : 19,
►  Side Effect : postural hypotension, syncope, headache, Dizziness, asthenia,
Ref :-   Book : Goodman    Page : 308   Edition : 12,

►  Drug Interaction : Drug interaction of Prazosin is with hypotension,  Tenecteplase , Clopamide , Zonisamide , Suxamethonium/Succinylcholinechloride (Suxamethonium chloride) , Mivacurium Chloride ,
Ref :-   Book : Martindale    Page : 1510   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The hypotensive effects of prazosin may be enhanced by use with diuretics and other antihypertensives, and by alcohol and other drugs that cause hypotension. The risk of first-dose hypotension may be particularly increased in patients receiving beta blockers or calcium channel blockers,
Ref :-   Book : Martindale    Page : 1510   Edition : 37,


►  Contraindication : heart failure, not drive or operate machinery,
Ref :-   Book : Martindale    Page : 1510   Edition : 37,
  ►  Mechanism of Action :   Prazosin is an alpha blocker that acts by selective blockade of alpha1-adrenoceptors.Prazosin produces peripheral dilatation of both arterioles and veins and reduction of peripheral resistance, usually without reflex tachycardia.,
Ref :-   Book : Martindale    Page : 1511   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- fish oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • omega 3 fatty acid have cardioprotective effect --- ( Artham, S. (2008). Fish Oil in Primary and Secondary Cardiovascular Prevention. The Oshsner Journal, 8(2), 49 -60. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096360/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1510   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1510   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 1510   Edition : 37,