Prazosin is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1511   Edition : 37   Martindale    Page : 1475   Edition : 38  

  ►   Brandname : Minipress, Hypovase, Kentovase, Prazocip, Cyber, Czopress
  ►  Strength : Capsule with 1 mg.  Capsule with 2 Mg.  Capsule with 5 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1511   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral Capsule In hypertension, the usual initial dose is 500 micrograms two or three times daily for 3 to 7 days; if tolerated the dose may then be increased to 1 mg two or three times daily for a further 3 to 7 days, and thereafter gradually increased, according to the patient’s response, to a usual maximum of 20 mg daily in divided doses.
2 Raynaud’s syndrome Oral 500 micrograms b.d. Then increasing to a maintenance dose not exceeding 2 mg twice daily.
3 Benign prostatic hyperplasia Oral 500 micrograms b.d. Then increasing to a maintenance dose not exceeding 2 mg twice daily.
4 Heart failure Oral 500 micrograms The treatment has been started with 500 micrograms two to four times daily and increased gradually according to response; the usual maintenance dose has been 4 to 20 mg daily. Prazosin is not recommended for the treatment of heart failure caused by mechanical obstruction, for example aortic or mitral valve stenosis, pulmonary embolism, and restrictive pericardial disease.

Ref :-  Book : Martindale    Page : 1474   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension Oral 0.05 0.1 mg/kg/day t.i.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1645   Edition : 19  
►  Side Effect : Postural hypotension, Syncope, Headache, Dizziness, Asthenia
Ref :-   Book : Goodman    Page : 308   Edition : 12.  

►  Drug Interaction : Drug interaction of Prazosin is with , Beta Blockers , , Alcohol, Calcium Channel Blockers ,  NA

  ►    Mechanism of Drug Drug Interaction :  The hypotensive effects of prazosin may be enhanced by use with diuretics and other antihypertensives, and by alcohol and other drugs that cause hypotension. The risk of first-dose hypotension may be particularly increased in patients receiving beta blockers or calcium channel blockers
Ref :-   Book : Martindale    Page : 1510   Edition : 37.  


►  Contraindication : Not drive or operate machinery
Ref :-   Book : Martindale    Page : 1510   Edition : 37.  
  ►  Mechanism of Action :   Prazosin is an alpha blocker that acts by selective blockade of alpha1-adrenoceptors.Prazosin produces peripheral dilatation of both arterioles and veins and reduction of peripheral resistance, usually without reflex tachycardia.
Ref :-   Book : Martindale    Page : 1511   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- fish oil with Another pathway.  

  ►  Pathway with its reference as follows :-
  • omega 3 fatty acid have cardioprotective effect --- ( Artham, S. (2008). Fish Oil in Primary and Secondary Cardiovascular Prevention. The Oshsner Journal, 8(2), 49 -60. )

  •   ►  URL --
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096360/ .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 1510   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   4 hours.  
    Ref :-   Book : Martindale    Page : 1510   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   1,    Max value :-   3 hours after an oral dose..  
    Ref :-   Book : Martindale    Page : 1510   Edition : 37.