Prednisolone is a Medicine belongs to Glucocorticoid for oral & parenteral use group whose information about Brand can be referenced from   Book : Martindale    Page : 1682   Edition : 37,

  ►   Brandname : Predone,Wysolone,Omnacortil,Predone,Deltacortril,Deltastab,Precortisyl,Ak-Pred

  ►  Strength : Tablet with 5  mg, Tablet with 25  mg, Solution with 5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1681   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1681   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anti-inflammatory activity Oral 2.5 60 mg Tablet Daily in divided doses.
2 Anti-inflammatory activity IM 25 100 mg Injection Once or twice weekly.
3 Anti-inflammatory activity intra-articular injection 5 25 mg Injection
4 Inflammatory conditions of the eyes or ears Topical 0.5 % drops

Ref :-  Book : Martindale    Page : 1681   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Allergic conditions Oral 5 mg Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 794   Edition : 19,
Precaution :- If a Patient is using 'Prednisolone' drug in  PEPTIC ULCER DISEASE  disease, then Please do not use .

►  Side Effect : delayed wound healing, hypertension, hypokalaemic alkalosis, increased susceptibility to infection, oedema,
Ref :-   Book : Martindale    Page : 1681   Edition : 37,

►  Drug Interaction : Drug interaction of Prednisolone is with Phenytoin , liraglutide , Ketoconazole , Carbamazapine , Rifampicin ,
Ref :-   Book : Martindale    Page : 1680.3   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Concurrent use of barbiturates, carbamazepine, phenytoin, primidone, or rifampicin may enhance the metabolism and reduce the effects of systemic corticosteroids. Conversely oral contraceptives or ritonavir may increase plasma concentrations of corticosteroids. Use of corticosteroids with potassium-depleting diuretics, such as thiazides or furosemide, may cause excessive potassium loss. There is also an increased risk of hypokalaemia with concurrent amphotericin B or bronchodilator therapy with xanthines or beta2 agonists. There may be an increased incidence of gastrointestinal bleeding and ulceration when corticosteroids are given with NSAIDs. Response to anticoagulants may be altered by corticosteroids and requirements of antidiabetic drugs and antihypertensives may be increased. Corticosteroids may decrease serum concentrations of salicylates and may decrease the effect of anticholinesterases in myasthenia gravis.,
Ref :-   Book : Martindale    Page : 1632   Edition : 37,


►  Contraindication : renal impairment, heart failure, myocardial infraction, , Diabetes mellitus, Epilepsy, Glaucoma, hyperthyroidism, osteoporosis, hepatic impairment, peptic ulcer disease, Psychosis,
Ref :-   Book : Martindale    Page : 1631   Edition : 37,
  ►  Mechanism of Action :   mimic cortisol function by acting as agonists at the glucocorticoid receptor,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 503   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Aloe vera with Another pathway, Onion with Another pathway,

  ►  Pathway with its reference as follows :-
  • anti-inflamatory --- ( B. Aggarwal, B., Prasad, S., Reuter, S., Kannappan, R., R. Yadav, V., & Park, B. et al. (2011). Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach. Current Drug Targets, 12(11), 1595-1653 )
  • antiallergic activity --- (Pdr For Herbal Medicine. 4th ed. 2016. Print. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170500/, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- ALOE VERA with Cause loss of potasssium lead to toxicity , GINSENG I.E ASHWAGANDHA with Interact when taken together, MELATONIN with Cause adverse interaction ,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1681   Edition : 37,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1681   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1681   Edition : 37,