Pregabalin is a Medicine belongs to Antiepileptics group whose information about Brand can be referenced from   Book : Martindale    Page : 547   Edition : 38      Page :   Edition :   

  ►   Brandname : Gabafit, Gabanext, Lyrica, Pregaba, Pregaba M, Pregaba Plus
  ►  Strength : Capsule with 25 mg.  Capsule with 50 mg.  Capsule with 75 mg.  Capsule with 100 mg.  Capsule with 150 Mg.  Capsule with 200 mg.  Capsule with 300 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Epilepsy 150 mg Capsule Pregabalin is given orally in 2 or 3 divided doses daily. The initial above daily dose is then increased after 1 week according to response to 300 mg daily and then to 600 mg daily after another week. Licensed drug information states that if pregabalin therapy has to be stopped, this should be done gradually over a minimum of 1 week, regardless of indication.
2 Generalised anxiety disorder Oral 150 mg Capsule Above given initial daily dose may then be increased at weekly intervals in steps of 150 mg, to a maximum of 600 mg daily. Licensed drug information states that if pregabalin therapy has to be stopped, this should be done gradually over a minimum of 1 week, regardless of indication.
3 Neuropathic pain Oral Capsule For neuropathic pain the initial dose in the UK is 150 mg daily increased after 3 to 7 days according to response to 300 mg daily and then to 600 mg daily after another 7 days. Licensed drug information states that if pregabalin therapy has to be stopped, this should be done gradually over a minimum of 1 week, regardless of indication.
4 Fibromyalgia Oral 150 mg Capsule The above given initial dose is increased after 1 week according to response to 300 mg daily and then to 450 mg daily if necessary. Licensed drug information states that if pregabalin therapy has to be stopped, this should be done gradually over a minimum of 1 week, regardless of indication.

Ref :-  Book : Martindale    Page : 546   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Peripheral oedema, Xerostomia, Asthenia, Ataxia, Dizziness, Somnolence, Tremor, Blurred Vision, Diplopia, Euphoria, Serious adverse effect is, Angioedema
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 237   Edition : 3.  

►  Drug Interaction : Drug interaction of Pregabalin is with NA

  ►    Mechanism of Drug Drug Interaction : 
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : , Hypersensitivity
Ref :-   Book :    Page :    Edition : .   Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 237   Edition : 3.  
  ►  Mechanism of Action :   In spite of their close structural resemblance to GABA, gabapentin and pregabalin do not act directly on GABA receptors. They may, however, modify the synaptic or nonsynaptic release of GABA. Gabapentin and pregabalin bind avidly to the α 2 δ subunit of voltage-gated Ca 2+ channels. This appears to underlie the main mechanism of action, which is decreasing Ca 2+ entry, with a predominant effect on presynaptic N-type channels. A decrease in the synaptic release of glutamate provides the antiepileptic effect.
Ref :-   Book : Basic & Clinical pharmacology    Page : 413   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fish with same pathway.   chondrondendron platphyllum with same pathway.   Manespermum dauricum with same pathway.   Manespermum dauricum with same pathway.   Manespermum dauricum with same pathway.   Peganum harmala with same pathway.  

  ►  Pathway with its reference as follows :-
  • Bind alpha 2 deltasubunits of voltage gated and calcium channels.VGCC. --- ( Alaoui 1 ,, Chaymae. "Inhibition Of Voltage-Gated Calcium Channels By Natural Alkaloids : Pharmacological And Therapeutic Effects". International Journal of Science and Research (IJSR) Index Copernicus Value (2013): 6.14 | Impact Factor (2013): 4.438.2319-7064 (2016): n. pag. Print. )
  • Bind alpha 2 deltasubunits of voltage gated and calcium channels.VGCC. --- (Alaoui 1 ,, Chaymae. "Inhibition Of Voltage-Gated Calcium Channels By Natural Alkaloids : Pharmacological And Therapeutic Effects". International Journal of Science and Research (IJSR) Index Copernicus Value (2013): 6.14 | Impact Factor (2013): 4.438.2319-7064 (2016): n. pag. Print. )

  •   ►  URL --
  • https://www.ijsr.net/archive/v4i9/SUB158303.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 546   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   Mean half life; 6.3 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 546   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 546   Edition : 37.