Prilocaine is a Medicine belongs to Local anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 2030   Edition : 37,

  ►   Brandname : Citanest,Citanest with Octapressin

  ►  Strength : Injection with 4  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 463   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Basic & Clinical pharmacology    Page : 463   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Local anaesthesia 400 mg Injection
2 Local anaesthesia 300 mg Injection With felypressin.
3 Dental infiltration 40 80 mg Injection

Ref :-  Book : Martindale    Page : 2030   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Local anaesthesia < 6 Month 5 mg/kg Injection
2 Dental infiltration >10 Year 40 mg Injection
3 Dental infiltration >10 Year 30 60 mg Injection

Ref :- Book : Martindale    Page : 2030   Edition : 37,
►  Side Effect : cardiac or respiratory arrest, Arrhythmias, decreased myocardial contractility, methaemoglobinaemia, seizure, tinnitus, paraesthesia, tremor, Somnolence, hypotension, Skin irritation, constipation, porphyria,
Ref :-   Book : Martindale    Page : 2030   Edition : 37,

►  Drug Interaction : Drug interaction of Prilocaine is with Adrenaline, Acarbose , , , Amlodipine ,
Ref :-   Book : Martindale    Page : 2013   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  If local anaesthetics containing adrenaline are given for epidural or paracervical block during labour the use of an oxytocic drug post partum may lead to severe hypertension. Methaemoglobinaemia may occur at lower doses of prilocaine in patients receiving therapy with other drugs known to cause such conditions (e.g. sulfonamides such as sulfamethoxazole in co-trimoxazole),
Ref :-   Book : Martindale    Page : 2013   Edition : 37,


►  Contraindication : Hypersensitivity, congenital methemoglobinemia, ideopathic methemoglobinemia,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 161   Edition : 3,
  ►  Mechanism of Action :   Inhibit voltage gated sodium channels in excitable cell membrane,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 161   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 2030   Edition : 37,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA