Primaquine is a Medicine belongs to antimalarial group whose information about Brand can be referenced from   Book : Martindale    Page : 663   Edition : 37,

  ►   Brandname : Malirid,PMQ-INGA,Primacip

  ►  Strength : Tablet with 26.3  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 935   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 935   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Malaria Oral 15 mg Tablet Daily for 14 days.
2 Malaria Oral 500 micrograms/kg Tablet Daily.
3 G6PD deficiency Oral 45 mg Tablet Once every 7 days for 8 weeks For patients with G6PD deficiency.
4 G6PD deficiency Oral 750 micrograms/kg Tablet o.d. Every 7 days for 8 weeks.

Ref :-  Book : Martindale    Page : 662   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Malaria Oral 250 micrograms/kg Tablet o.d.
2 Malaria Oral 500 750 micrograms/kg Tablet

Ref :- Book : Martindale    Page : 662   Edition : 37,
Precaution :- If a Patient is using 'Primaquine' drug in  Malaria  disease, then Please be avoided in patients having G6PD deficiency .

Precaution :- If a Patient is using 'Primaquine' drug in  Malaria  disease, then Please not be given in pregnancy and during lactation phase .

Precaution :- If a Patient is using 'Primaquine' drug in  malaria  disease, then Please G6PD DEFICIENCY TO RULE OUT BEFORE GIVING .

Precaution :- If a Patient is using 'Primaquine' drug in  thallasemia  disease, then Please Avoid .

►  Side Effect : abdominal pain, GI distress, nausea, vomiting, leucocytosis, methaemoglobinaemia, haemolytic anaemia, hypertension, cardiac arrhythmia, leucopenia, agranulocytosis, Leukocytosis, mild anaemia,
Ref :-   Book : Martindale    Page : 662   Edition : 37,

►  Drug Interaction : Drug interaction of Primaquine is with Mepacrine,
Ref :-   Book : Martindale    Page : 662   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Primaquine should not be used with drugs liable to induce haemolysis or bone marrow depression. Theoretically, mepacrine may increase the plasma concentrations of primaquine resulting in a higher risk of toxicity, and it has been recommended that these drugs should not be used together.,
Ref :-   Book : Martindale    Page : 662   Edition : 37,


►  Contraindication : granulocytopenia , lupus erythematosus, G6PD deficiency,
Ref :-   Book : Martindale    Page : 662   Edition : 37, Martindale    Page : 602   Edition : 37,
  ►  Mechanism of Action :   inhibits the plasmodial electron transport chain ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 644   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Neem with Another pathway,

  ►  Pathway with its reference as follows :-
  • Nimbin and Nimbidin have Anti-malerial property --- (Prophylatic Potential of Lemon Grass and Neem as Antimalarial Agents. (2010). Journal Of American Science, 6(8). )

  •   ►  URL -- http://www.jofamericanscience.org/journals/am-sci/am0608/62_3089am0608_503_507.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 622   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   3 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 662   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 662   Edition : 37,