Primidone is a Medicine belongs to Antiseizure drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 548   Edition : 37,

  ►   Brandname : Mysoline

  ►  Strength : Tablet with 50  mg, Tablet with 250  mg, Suspension with 250/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 548   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Epilepsy Oral 125 mg Tablet h.s.
2 Essential tremor Oral 50 mg Syrup
3 Essential tremor Oral 62.5 mg Tablet

Ref :-  Book : Martindale    Page : 548   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Seizures 2 Year Oral 250 500 mg Tablet
2 Seizures 2 Year 5 Year Oral 500 750 mg Tablet
3 Seizures 6 Year 9 Year Oral 750 1000 mg Tablet

Ref :- Book : Martindale    Page : 548   Edition : 37,
►  Side Effect : ataxia, Dizziness, drowsiness, headache, nausea, vomiting, nystagmus, Skin rashes, visual disturbances, agranulocytosis,
Ref :-   Book : Martindale    Page : 548   Edition : 37,

►  Drug Interaction : Drug interaction of Primidone is with Phenytoin , Warfarin , Carbamazapine , Vigabatrin ,
Ref :-   Book : Martindale    Page : 537   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Both phenytoin and carbamazepine have been reported to enhance the metabolism of primidone to phenobarbital and when primidone was combined with phenytoin there have been instances of phenobarbital toxicity. Vigabatrin has been lower plasma concentrations of primidone. Valproate may increase plasma concentrations of primidone and phenobarbital, but patient response seems to be inconsistent.,
Ref :-   Book : Martindale    Page : 548   Edition : 37,


►  Contraindication : NA
  ►  Mechanism of Action :   Block high-frequency firing neurons through action on voltage gated (VG) Na+ channels decreasing synaptic release of glutamate but converted to phenobarbital,
Ref :-   Book : Basic & Clinical pharmacology    Page : 425   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- CALCIUM with Long-term develop below normal blood levels of calcium , which may be related to drug -induced vitamin -D deficiency. ., FOLIC ACID with Reduces blood levels of folic acid dramatically increases homocysteine levels .,

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FOLATE with Impairs metabolism & reduce absorption,high dose of folate antagonize effects., VITAMIN B6 with Decreases serum vitamin lenvel., VITAMIN B12 with Decreases serum vitamin level.,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 548   Edition : 37,


    ►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   15 hours,
    Ref :-   Book : Martindale    Page : 548   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,