Probenecid is a Medicine belongs to Anti gout group whose information about Brand can be referenced from   Book : Martindale    Page : 608   Edition : 37,

  ►   Brandname : Bencid,Benemid

  ►  Strength : Tablet with 500  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 608   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gout Oral 250 mg Tablet b.d.
2 Gonorrhoea Oral 1 gm With a suitable oral antibacterial,

Ref :-  Book : Martindale    Page : 608   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Gout 2 Year <2 Year >= 50 kg Oral 25 mg/kg Tablet

Ref :- Book : Martindale    Page : 608   Edition : 38,
►  Side Effect : vomiting, anorexia, headache, sore gums, flushing, alopecia, Dizziness, anaemia, urinary frequency, hypersensitivity reactions, fever, dermatitis, pruritus, Urticaria, leucopenia, hepatic necrosis, nephrotic syndrome, aplastic anaemia, haemolytic anaemia, anaphylaxis, Stevens-Johnson syndrome,
Ref :-   Book : Martindale    Page : 607   Edition : 37,

►  Drug Interaction : Drug interaction of Probenecid is with Tenecteplase , Pyrazinamide , Chlorpropamide , Aspirin (Acetylsalicylic acid), Methotrexate, Ketorolac trometamol, Tranexamic acid , Amiloride , Etoricoxib , Amlodipine , Dapsone , Meropenem , Glipizide , Rifampicin , Tetrabenazine, Ganciclovir , Zalcitabine, Zidovudine, Famciclovir , Fospropofol , Lorazepam , Nitrazepam, Sertraline, Protamine sulphate , Indomethacin , Ketoprofen , meclofenamate, Naproxen , Paracetamol , Flumazenil , Thiopental Sodium , Midazolam ,
Ref :-   Book : Martindale    Page : 608   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The dose of probenecid may need to be increased if patients are also given drugs, such as diuretics or pyrazinamide, that increase the blood concentration of uric acid. Salicylates, including aspirin, and probenecid are mutually antagonistic and should not be given together. Probenecid may be given with some antibacterials such as the penicillins and cephalosporins to increase their effects. It has been reported that patients receiving probenecid require lower doses of thiopental for induction of anaesthesia. Probenecid may increase the speed of induction of anaesthesia with midazolam.,
Ref :-   Book : Martindale    Page : 608   Edition : 37,


►  Contraindication : blood disorders, peptic ulcer disease,
Ref :-   Book : Martindale    Page : 607,608   Edition : 37,
  ►  Mechanism of Action :   The actions of probenecid are confined largely to inhibition of the transport of organic acids across epithelial barriers. Probenecid inhibits the reabsorption of uric acid by organic anion transporters, principally URAT-1. Uric acid is the only important endogenous compound whose excretion is known to be increased by probenecid. The uricosuric action of probenecid is blunted by the co-administration of salicylates.,
Ref :-   Book : Goodman    Page : 999   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Saffron with Another pathway,

  ►  Pathway with its reference as follows :-
  • It inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules --- ( DrugBank: Colchicine. (2016). Drugbank.ca. Retrieved 22 June 2016 )

  •   ►  URL -- http://www.drugbank.ca/drugs/DB01394,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- RIBOFLAVIN with Decrease in Nutrient Level,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- CALCIUM with Increases urinary mineral excretion., MAGNESIUM with Increases urinary mineral excretion., POTASSIUM with Increases urinary mineral excretion.,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 608   Edition : 37,


    ►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   8 hours,
    Ref :-   Book : Martindale    Page : 608   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 608   Edition : 37,