Procainamide is a Medicine belongs to Sodium channel blockers group whose information about Brand can be referenced from   Book : Martindale    Page : 1514   Edition : 37  

  ►   Brandname : Procanbid, Pronestyl
  ►  Strength : Tablet with 250 Mg.  Tablet with 375 Mg.  Tablet with 500 mg.  Tablet with 750 Mg.  Tablet with 1000 Mg.  Injection with 500 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 249   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM
Reference :-   Book : Martindale    Page : 1513   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Arrhythmia Oral 50 mg/kg Every 3 hours.
2 Arrhythmia IV 100 mg Injection Every 5 minutes at a rate not exceeding 50 mg/minute until the arrhythmia has been suppressed.

Ref :-  Book : Martindale    Page : 1513   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Arrhythmia Oral 15 50 mg/kg

Ref :- Book : Martindale    Page : 1514   Edition : 37  
Precaution :- If a Patient is using 'Procainamide' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Procainamide' drug in  Ventricular tachycardia  disease, then Please contraindicated in complete heart block .

►  Side Effect : Severe hypotension, Ventricular fibrillation, Asystole, Hypersenstivity, Arthralgia, Arthritis, Myalgia, Pleural effusion, Pericarditis, Fever, Agranulocytosis, Eosinophilia, Neutropenia, Thrombocytopenia, Haemolytic anaemia, Hepatomegaly, Angioedema, Skin rashes, Urticaria, Flushing, Hypergammaglobulinaemia, Anorexia, Nausea, Vomiting, Bitter taste, Diarrhea, Mental depression, Dizziness, Psychosis, Hallucinations
Ref :-   Book : Martindale    Page : 1512   Edition : 37.  

►  Drug Interaction : Drug interaction of Procainamide is with Clopamide , Abatacept , Corticotropin , Potassium Permanganate , Neostigmine , Cimetidine , Trimethoprim
Ref :-   Book : Martindale    Page : 1513   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Procainamide may enhance the effects of antihypertensives, other antiarrhythmics and arrhythmogenic drugs, antimuscarinics, and neuromuscular blockers, and diminish those of parasympathomimetics, such as neostigmine. Procainamide is actively secreted by kidney tubules and interactions may occur with drugs secreted by the same pathway, such as cimetidine and trimethoprim.
Ref :-   Book : Martindale    Page : 1513   Edition : 37.  


►  Contraindication : Heart block , Myasthenia gravis, Digoxin toxicity, Heart failure
Ref :-   Book : Martindale    Page : 1513   Edition : 37.  
  ►  Mechanism of Action :   Moderate block of voltage – gated Na+ channels and block of K+ channels in ventricular myocytes ( decreases phase 0 upstroke velocity and prolongs repolarization )and SA node cell ( shifts threshold to more positive potentials and decreases slop of phase 4 depolarization
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 418   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Camphor tree with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Camphore have Anti arrhythemic effect --- (PDR for Herbal medicines. (2000) (4th ed.). U.S )

  •   ►  URL --
  • http://www.abebooks.com/PDR-Herbal-Medicines-4th-Edition-Thomson/14662393711/bd .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 1513   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   2.5 hours,    Max value :-   5 hours.  
    Ref :-   Book : Martindale    Page : 1513   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : .