Procarbazine is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 842   Edition : 37,

  ►   Brandname : Natulan,Matulane

  ►  Strength : Capsule with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 842   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 842   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Non Hodgkin’s lymphoma Oral 100 mg/m2 Capsule For 10 to 14 days of each 4- or 6-week cycle.
2 Non Hodgkin’s lymphoma Oral 50 mg Capsule Daily.

Ref :-  Book : Martindale    Page : 843   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hodgkin’s disease Oral 50 mg/m2 Capsule

Ref :- Book : Martindale    Page : 843   Edition : 37,
►  Side Effect : peripheral neuropathy, cerebellar dysfunction, acute encephalopathy, gastrointestinal disturbance, anorexia, nausea, vomiting, bone marrow depression, headache, hallucinations, Dizziness, peripheral neuropathies, paraesthesia, decreased reflexes, lethargy, ataxia, sleep disorders, tremor, coma, convulsion,
Ref :-   Book : Martindale    Page : 842   Edition : 37,

►  Drug Interaction : Drug interaction of Procarbazine is with Mycophenolate mofetil , Phentolamine ,
Ref :-   Book : Martindale    Page : 842   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Procarbazine is a weak MAOI and the possibility of reactions with other drugs and food, although very rare, must be borne in mind,
Ref :-   Book : Martindale    Page : 842   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 842   Edition : 37,
  ►  Mechanism of Action :   Procarbazine hydrochloride is a methylhydrazine derivative whose antineoplastic effect, although not fully understood, may resemble that of the alkylating agents; it appears to inhibit protein and nucleic acid synthesis and suppress mitosis,
Ref :-   Book : Martindale    Page : 842   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with Another pathway,

  ►  Pathway with its reference as follows :-
  • Curcumin have anticancerous effect --- ( Rahmani, A., Al Zohairy, M., Aly, S., & Khan, M. (2014). Curcumin: A Potential Candidate in Prevention of Cancer via Modulation of Molecular Pathways. Biomed Research International, 2014, 1-15. )

  •   ►  URL -- http://www.hindawi.com/journals/bmri/2014/761608/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 842   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA