Procarbazine is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 842   Edition : 37  

  ►   Brandname : Natulan, Matulane
  ►  Strength : Capsule with 50 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 842   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 842   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Non Hodgkin’s lymphoma Oral 100 mg/m2 Capsule For 10 to 14 days of each 4- or 6-week cycle.
2 Non Hodgkin’s lymphoma Oral 50 mg Capsule Daily.

Ref :-  Book : Martindale    Page : 843   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hodgkin’s disease Oral 50 mg/m2 Capsule

Ref :- Book : Martindale    Page : 843   Edition : 37  
►  Side Effect : Peripheral neuropathy, Cerebellar dysfunction, Acute encephalopathy, Gastrointestinal disturbance, Anorexia, Nausea, Vomiting, Bone marrow depression, Headache, Hallucinations, Dizziness, Peripheral neuropathies, Paraesthesia, Decreased reflexes, Lethargy, Ataxia, Sleep disorders, Tremor, Coma, Convulsion
Ref :-   Book : Martindale    Page : 842   Edition : 37.  

►  Drug Interaction : Drug interaction of Procarbazine is with Mycophenolate mofetil , Phentolamine
Ref :-   Book : Martindale    Page : 842   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Procarbazine is a weak MAOI and the possibility of reactions with other drugs and food, although very rare, must be borne in mind
Ref :-   Book : Martindale    Page : 842   Edition : 37.  


►  Contraindication : Hepatic impairment, Renal impairment
Ref :-   Book : Martindale    Page : 842   Edition : 37.  
  ►  Mechanism of Action :   Procarbazine hydrochloride is a methylhydrazine derivative whose antineoplastic effect, although not fully understood, may resemble that of the alkylating agents; it appears to inhibit protein and nucleic acid synthesis and suppress mitosis
Ref :-   Book : Martindale    Page : 842   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Curcumin have anticancerous effect --- ( Rahmani, A., Al Zohairy, M., Aly, S., & Khan, M. (2014). Curcumin: A Potential Candidate in Prevention of Cancer via Modulation of Molecular Pathways. Biomed Research International, 2014, 1-15. )

  •   ►  URL --
  • http://www.hindawi.com/journals/bmri/2014/761608/ .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 842   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA