Prochlorperazine is a Medicine belongs to Antiemetic group whose information about Brand can be referenced from   Book : Martindale    Page : 1127   Edition : 37  

  ►   Brandname : Bukatel, Emidoxyn, Stemetil, Vometil, Buccastem, Proziere, Stemetil, Compazine, Compro
  ►  Strength : Tablet with 5 Mg.  Tablet with 10 Mg.  Tablet with 25 Mg.  Capsule with 10 Mg.  Capsule with 15 mg.  Capsule with 30 Mg.  Solution with 1 mg/ml.  Suppository with 2.5 mg.  Suppository with 5 Mg.  Suppository with 25 Mg.  Injection with 5 mg/ml.  Buccal tablet with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12   Martindale    Page : 1126   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV, rectal, buccal
Reference :-   Book : Martindale    Page : 1126   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Nausea and vomiting Oral 5 10 mg Tablet b.d/t.i.d
2 Nausea and vomiting Oral 20 mg Tablet
3 Nausea and vomiting IM 12.5 mg Injection
4 Nausea and vomiting buccal 3 6 mg Buccal tablet b.d.
5 Nausea and vomiting rectal 25 mg Suppository b.d.
6 Psychoses Oral 12.5 mg Tablet b.d. Dose given daily for 7 days adjusted gradually to 75 to 100 mg daily according to response; some patients may be maintained on doses of 25 to 50 mg daily.
7 Psychoses IM 12.5 25 mg Injection b.d/t.i.d
8 Severe anxiety disorders Oral 5 10 mg Tablet t.i.d/q.i.d
9 Vertigo including that due to Meniere’s disease. Oral 15 30 mg Dose: given daily in divide doses; after several weeks the dose may be gradually reduced to 5 to 10 mg daily
10 Vertigo including that due to Meniere’s disease. buccal 3 6 mg Buccal tablet b.d.

Ref :-  Book : Martindale    Page : 1126   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Nausea and vomiting 1 Year Oral 250 mcg/kg b.d/t.i.d
2 Nausea and vomiting 2 Year 5 Year IM 1.25 2.5 mg Injection
3 Nausea and vomiting 5 Year 12 Year IM 5 6.25 mg Injection
4 Schizophrenia 2 Year 5 Year oral / rectal 20 mg Tablet/ Suppository
5 Schizophrenia 6 Year 12 Year oral / rectal 25 mg Tablet/ Suppository

Ref :- Book : Martindale    Page : 1126   Edition : 37  
►  Side Effect : Dry mouth, Constipation, Difficulty in micturition, Blurred Vision, Mydriasis, Tachycardia, ECG changes, Hypotension (usually orthostatic), Delirium, Agitation, Hypersensitivity reactions, Urticaria, Exfoliative dermatitis, Erythema multiforme, Contact sensitivity, A syndrome resembling SLE, Photosensitivity reactions, Haematological disorders, Haemolytic anaemia, Aplastic anaemia, Thrombocytopenic purpura, Eosinophilia, Fatal agranulocytosis, Acute dystonia, Parkinson- like syndrome, Akathisia, Tardive dyskinesia, Perioral tremor, Neuroleptic malignant syndrome, amenorrhoea, Galactorrhoea, Gynaecomastia, Hyperprolactinaemia, Weight gain, Hyperglycaemia, Altered glucose tolerance, Hypo- or hyperthermia depending on environment, Hypercholesterolaemia, Pain and irritation at the injection site may occur on injection. Nodule formation may occur after intramuscular injection.
Ref :-   Book : Martindale    Page : 1072,1126   Edition : 37.   Martindale    Page : 1072,1126   Edition : 37.  

►  Drug Interaction : Drug interaction of Prochlorperazine is with Alcohol, General anaesthetics , Hypnotics, Anxiolytics, Opioids, , Antimalarials, Tricyclic antidepressants,  Cisapride
Ref :-   Book : Martindale    Page : 1076, 1126   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Symptoms of CNS depression may be enhanced by other drugs with CNS-depressant properties including alcohol, general anaesthetics, hypnotics, anxiolytics, and opioids. When given with other drugs that produce orthostatic hypotension, There is an increased risk of arrhythmias when antipsychotics are used with drugs that prolong the QT interval, including certain antiarrhythmics, other antipsychotics, some non-sedating antihistamines, antimalarials, and cisapride; use with diuretics that cause electrolyte imbalance (particularly hypokalaemia) may also have the same effect. There is also an increased risk of arrhythmias when tricyclic antidepressants are used with antipsychotics that prolong the QT interval.
Ref :-   Book : Martindale    Page : 1076,1126   Edition : 37.  


►  Contraindication : Pre-existing CNS depression or coma, Bone marrow suppression, Phaeochromocytoma, Prolactin-dependent tumours, It should be used with caution or not at all in patients with impaired liver, kidney, cardiovascular, cerebrovascular, and respiratory function and in those with angle-closure glaucoma, a history of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia, or urinary retention.
Ref :-   Book : Martindale    Page : 1075,1126   Edition : 37.  
  ►  Mechanism of Action :   Prochlorperazine is a phenothiazine antipsychotic. It has a wide range of activity arising from its depressant actions on the CNS and its alpha-adrenergic blocking and antimuscarinic activities. Prochlorperazine is a dopamine inhibitor; the turnover of dopamine in the brain is also increased. There is some evidence that the antagonism of central dopaminergic function, especially at the D2-dopaminergic receptor, is related to therapeutic effect in psychotic conditions. Prochlorperazine possesses sedative properties. It has antiemetic, serotonin-blocking, and weak antihistaminic properties and slight ganglion-blocking activity. Prochlorperazine can relax skeletal muscle.
Ref :-   Book : Martindale    Page : 1078-1126   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- ALCOHOL with Cause excessive drawsinesss when taken with drug..  

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ►   Route of Elimination :   Hepatic (Metabolism)
    Ref :-   Book : Martindale    Page : 1126   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   6.8 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1126   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   5 hours.  
    Ref :-   Book : Martindale    Page : 1126   Edition : 37.