Prochlorperazine is a Medicine belongs to Motility and antiemetic agent group whose information about Brand can be referenced from   Book : Martindale    Page : 1127   Edition : 37,

  ►   Brandname : Bukatel,Emidoxyn,Stemetil,Vometil,Buccastem,Proziere,Stemetil,Compazine,Compro

  ►  Strength : Tablet with 5  Mg, Tablet with 10  Mg, Tablet with 25  Mg, Capsule with 10  Mg, Capsule with 15  mg, Capsule with 30  Mg, Solution with 1  mg/ml, Suppository with 2.5  mg, Suppository with 5  Mg, Suppository with 25  Mg, Injection with 5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV, rectal, buccal,
Reference :-   Book : Martindale    Page : 1126   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Nausea and vomiting Oral 5 10 mg Tablet b.d/t.i.d
2 Nausea and vomiting Oral 20 mg Tablet
3 Nausea and vomiting IM 12.5 mg Injection
4 Nausea and vomiting buccal 3 6 mg b.d.
5 Nausea and vomiting Oral 5 10 mg Tablet t.i.d/q.i.d
6 Psychoses Oral 12.5 mg Tablet b.d. For 7 days.
7 Psychosis Oral 5 10 mg Tablet t.i.d/q.i.d
8 Severe anxiety disorders Oral 5 10 mg Tablet t.i.d/q.i.d
9 Vertigo Oral 15 30 mg Tablet Daily in divided dose.

Ref :-  Book : Martindale    Page : 1126   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Migraine IV 0.15 mg/kg Injection
2 Vomiting Oral 0.3 mg/kg Tablet b.d/t.i.d

Ref :- Book : Nelson's textbook of Pediatrics    Page : 2044   Edition : 19, Nelson's textbook of Pediatrics    Page : 1244   Edition : 19,
►  Side Effect : dry mouth, constipation, difficulty in micturition, Blurred Vision, mydriasis, tachycardia, ECG changes, hypotension, delirium, agitation, Urticaria, exfoliative dermatitis, erythema multiforme, contact sensitivity, photosensitivity, haematological disorders, local irritation, cardiac arrhythmia, catatonic-like states, insomnia, drowsiness, nightmares, Depression, Miosis, convulsion, nasal congestion, abnormal liver fuction tests, inhibition of ejaculation, impotence, priapism, pigmentary retinopathy,
Ref :-   Book : Martindale    Page : 1072,1126   Edition : 37,

►  Drug Interaction : Drug interaction of Prochlorperazine is with Zonisamide , Testosterone , Norgestrel , Bezafibrate , Ethinylestradiol , Guanethidine, , Abatacept , , Carbimazole , Epinephrine (adrenaline) , Cisapride , Tenecteplase ,
Ref :-   Book : Martindale    Page : 1076   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Symptoms of CNS depression may be enhanced by other drugs with CNS-depressant properties including alcohol, general anaesthetics, hypnotics, anxiolytics, and opioids. Phenothiazines have been reported to reduce the antihypertensive action of guanethidine and other adrenergic neurone blockers. In theory, antipsychotics with dopamine-blocking activity and dopaminergic drugs such as those used to treat parkinsonism may be mutually antagonistic. There is also an increased risk of arrhythmias when tricyclic antidepressants are used with antipsychotics that prolong the QT interval, including certain antiarrhythmics, other antipsychotics, some non-sedating antihistamines, antimalarials, and cisapride; use with diuretics that cause electrolyte imbalance (particularly hypokalaemia) may also have the same effect. ,
Ref :-   Book : Martindale    Page : 1076   Edition : 37,


►  Contraindication : CNS depression, coma, bone marrow suppression, phaeochromocytoma, Prolactin dependent tumor,
Ref :-   Book : Martindale    Page : 1126   Edition : 37,
  ►  Mechanism of Action :   Prochlorperazine is a phenothiazine antipsychotic. It has a wide range of activity arising from its depressant actions on the CNS and its alpha-adrenergic blocking and antimuscarinic activities. Chlorpromazine is a dopamine inhibitor; the turnover of dopamine in the brain is also increased. There is some evidence that the antagonism of central dopaminergic function, especially at the D2-dopaminergic receptor, is related to therapeutic effect in psychotic conditions. Chlorpromazine possesses sedative properties. It has antiemetic, serotonin-blocking, and weak antihistaminic properties and slight ganglion-blocking activity. Chlorpromazine can relax skeletal muscle.,
Ref :-   Book : Martindale    Page : 1078   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- BACCOPA MONNERIE with Dietary Substance is Drug Enhancer,

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- ALCOHOL with Cause excessive drawsinesss when taken with drug.,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1126   Edition : 37,


    ►    Plasma Half-life :   Min value :-   6.8 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1126   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   5 hours,
    Ref :-   Book : Martindale    Page : 1126   Edition : 37,