Progesterone is a Medicine belongs to Progestions group whose information about Brand can be referenced from   Book : Martindale    Page : 2335   Edition : 37  

  ►   Brandname : Crinone, Cyclogest, Gestone, Utrogestan, Crinone, Endometrin, Prochieve, Progestasert, Prometrium
  ►  Strength : Capsule with 100 Mg.  Capsule with 200 Mg.  Gel with 4 %.  Gel with 8 %.  Injection with 50 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, , rectal
Reference :-   Book : Martindale    Page : 2334   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Amenorrhoea IM 5 10 mg Injection For about 5 to 10 days until 2 days before the anticipated onset of menstruation.
2 Amenorrhoea Vaginal 45 mg Gel On alternate days for up to 6 doses.
3 Amenorrhoea Oral 400 mg Tablet h.s. For 10 days.
4 Miscarriage IM 25 100 mg Injection bis in 7 d.
5 Ovarian failure Vaginal 100 mg Tablet b.d/t.i.d
6 Ovarian failure Vaginal 400 600 mg Capsule Daily, in 2 or 3 divided doses.
7 Premenstrual syndrome Vaginal 200 400 mg b.d.
8 Menopausal Hormone replacement therapy Oral 200 mg Capsule Daily at bedtime for 12 to 14 days of each month.

Ref :-  Book : Martindale    Page : 2300   Edition : 38   Martindale    Page : 2334   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Progesterone' drug in  Acute Intermittent Porphyria  disease, then Please Do not use .

►  Side Effect : Gastrointestinal disturbance, Changes in appetite, Changes in weight, Fluid retention, Oedema, Acne, Chloasma, Allergic skin rashes, Urticaria, Mental depression, Breast changes, Gynaecomastia, Changes in libido, Hair loss, Hirsutism, Fatigue, Drowsiness, Insomnia, Fever, Headache, Premenstrual syndrome-like symptoms, Altered menstrual cycles, Irregular menstrual bleeding
Ref :-   Book : Martindale    Page : 2333   Edition : 37.  

►  Drug Interaction : Drug interaction of Progesterone is with Carbamazapine , Griseofulvin , Phenobarbital , Phenytoin , Rifampicin , Cyclosporine
Ref :-   Book : Martindale    Page : 2333   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Enzyme-inducing drugs such as carbamazepine, griseofulvin, phenobarbital, phenytoin, and rifampicin may enhance the clearance of progesterone and the progestogens.
Ref :-   Book : Martindale    Page : 2333   Edition : 37.  


►  Contraindication : , Cardiac impairment, Renal impairment, Asthma, Epilepsy, Migraine, Diabetes mellitus, Thromboembolism
Ref :-   Book : Martindale    Page : 2333   Edition : 37.  
  ►  Mechanism of Action :   Progestins enter the cells and bind to progestron receptors that are distributed between the nucleus and cytoplasm. The ligand receptor complex bind to a progesteron response element to activate gene transcriptions. a progesterone receptor complex form a dimer before binding to DNA. It can form hetrodimers as well as homodimers between to isoforms A and B. These isoform are produced by alternative splicing of the same gene.
Ref :-   Book : Basic & Clinical pharmacology    Page : 723   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Stinging nettle i. e. Bichu ghas with Another pathway.   Sarsaparilla i.e. anantmool with Another pathway.   Wild yam i.e.jangali ratalu with same pathway.  

  ►  Pathway with its reference as follows :-
  • Raised progesteron level --- (: Henners, M. (2004). Better nutrition first in natural health. )
  • Wild yum having diosgenin which is precursor for the production of progesterone. --- (Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press. )
  • Raised progesteron level --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • https://books.google.co.in/books?id=GwYAAAAAMBAJ&pg=PA16&lpg=PA16&dq=progesterone+activating+herb+journal&source=bl&ots=uUoZYaUBjX&sig=Ezpf3Xl7nJQEi3wIf5z9JJNvSxU&hl=en&sa=X&ved=0ahUKEwjMq8ju4rPOAhXL2RoKHRYHD-EQ6AEIUDAH#v=onepage&q=progesterone%20activating%20herb%20journal&f=false .
  • https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 2334   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   0.83 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2332   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : .