Proguanil is a Medicine belongs to antimalarial group whose information about Brand can be referenced from   Book : Martindale    Page : 664   Edition : 37,

  ►   Brandname : Malarone

  ►  Strength : Tablet with nf  ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 663   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prophylaxis of malaria Oral 200 mg Tablet After food.
2 Prophylaxis of malaria Oral 100 mg Tablet Daily With atovaquone .
3 Uncomplicated falciparum malaria Oral 400 mg Tablet With atovaquone 1 g, each orally as a single dose for 3 consecutive days.

Ref :-  Book : Martindale    Page : 663   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : diarrhoea, hypersensitivity reactions, Urticaria, angioedema, seizure, psychotic disorder,
Ref :-   Book : Martindale    Page : 663   Edition : 37,

►  Drug Interaction : Drug interaction of Proguanil is with Fluvoxamine, Warfarin ,
Ref :-   Book : Martindale    Page : 663   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Fluvoxamine can virtually abolish the metabolism of proguanil to its active metabolite cycloguanil via an inhibitory effect on the cytochrome P450 isoenzyme CYP2C19. ,
Ref :-   Book : Martindale    Page : 663   Edition : 37,


►  Contraindication : pregnancy, renal impairment,
Ref :-   Book : Martindale    Page : 663   Edition : 37,
  ►  Mechanism of Action :   proguanil is a derivative of pyrimidine and like pyrimethamine , is an inhibitor of dihydrofolate reductase ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 636   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Guargum with Another pathway,

  ►  Pathway with its reference as follows :-
  • Resin Acid have .Anti-malarial property --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan.,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 663   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   20 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 663   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 663   Edition : 37,