Promethazine is a Medicine belongs to Sedating antihistaminic/Motility and antiemetic agent group whose information about Brand can be referenced from   Book : Martindale    Page : 641   Edition : 37,

  ►   Brandname : Avomine,Emin,Phenergan,Phenadoz,Promethegan

  ►  Strength : Tablet with 10  Mg, Tablet with 13.5  Mg, Tablet with 25  Mg, Tablet with 50  Mg, Syrup with 5/5  mg/ml, Syrup with 6.5/5  mg/ml, Syrup with 10/5  mg/ml, Suppository with 10  Mg, Suppository with 12.5  Mg, Suppository with 25  Mg, Suppository with 50  Mg, Injection with 25  mg/ml, Injection with 50  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, rectal,
Reference :-   Book : Martindale    Page : 641   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Allergic conditions Oral 25 mg Tablet At night.
2 Insomnia Oral 20 50 mg Tablet At night.
3 Motion sickness Oral 20 mg Tablet The night before travelling.
4 Motion sickness Oral 25 Tablet The night before travelling.
5 Nausea and vomiting Oral 25 mg Tablet At night.
6 Severe vomiting in pregnancy Oral 25 mg Tablet At night.
7 Nausea and vomiting IM 25 50 mg Injection

Ref :-  Book : Martindale    Page : 640   Edition : 37, Martindale    Page : 641   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Allergic conditions 2 Year 5 Year Oral 5 15 mg Tablet
2 Allergic conditions 5 Year 10 Year Oral 10 25 mg Tablet
3 Sedation 2 Year 5 Year Oral 15 20 mg Tablet
4 Sedation 5 Year 10 Year Oral 20 25 mg Tablet
5 Motion sickness 2 Year 5 Year Oral 5 mg Tablet
6 Motion sickness 5 Year 10 Year Oral 10 mg Tablet
7 Motion sickness 5 Year 10 Year Oral 12.5 mg Tablet
8 Nausea and vomiting 5 Year 10 Year Oral 12.5 37.5 mg Tablet
9 Nausea and vomiting <10 Year Oral 25 mg Tablet
10 Allergic conditions 5 Year 10 Year IM 6.25 12.5 mg Injection
11 sedative 5 Year 10 Year IM 6.25 12.5 mg Injection
12 sedative 12 Year 18 Year IM 25 50 mg Injection q.i.d.

Ref :- Book : Martindale    Page : 641   Edition : 37,
►  Side Effect : CNS depression, slight drowsiness to deep sleep, lassitude, Dizziness, incoordination, headache, psychomotor impairment, dry mouth, thickened respiratory-tract secretions, Blurred Vision, urinary difficulty or retention, constipation, increased gastric reflux, nausea, vomiting, diarrhea, epigastric pain, bradycardia, tachycardia, Pain, burning , Paralysis, thrombophlebitis, necrosis, gangrene, blood disorder, granulocytopenia, leucopenia, haemolytic anaemia, thrombocytopenia, hypotension, extrapyramidal effects,
Ref :-   Book : Martindale    Page : 611,640   Edition : 37,

►  Drug Interaction : Drug interaction of Promethazine is with Zonisamide , Norgestrienone , Norgestrel , Ethinylestradiol , Bezafibrate , , Atropine , ,
Ref :-   Book : Martindale    Page : 613   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Sedating antihistamines may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs). It has been suggested that some sedating antihistamines could mask the warning signs of damage caused by ototoxic drugs such as aminoglycoside antibiotics,
Ref :-   Book : Martindale    Page : 613   Edition : 37,


►  Contraindication : urinary retention, prostatic hyperplasia, pyloroduodenal obstruction, angle -closure glucoma,
Ref :-   Book : Martindale    Page : 612,640   Edition : 37,
  ►  Mechanism of Action :   Inverse agonists that bind preferentially to the inactive conformation of the H1 receptor and shift the equilibrium toward the inactive receptor state. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 774   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 640   Edition : 37,


►    Plasma Half-life :
  Min value :-   5 hours,    Max value :-   14 hours,
Ref :-   Book : Martindale    Page : 640   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours,
Ref :-   Book : Martindale    Page : 640   Edition : 37,