Promethazine is a Medicine belongs to antihistamines group whose information about Brand can be referenced from   Book : Martindale    Page : 641   Edition : 37  

  ►   Brandname : Avomine, Fenezan, Atosil, Closin, Emin, Phenergan, Sominex, Ziz, Phenadoz
  ►  Strength : Tablet with 10 Mg.  Tablet with 13.5 Mg.  Tablet with 25 Mg.  Tablet with 50 Mg.  Syrup with 5/5 mg/ml.  Syrup with 6.5/5 mg/ml.  Syrup with 10/5 mg/ml.  Suppository with 10 Mg.  Suppository with 12.5 Mg.  Suppository with 25 Mg.  Suppository with 50 Mg.  Injection with 25 mg/ml.  Injection with 50 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, rectal, Topical
Reference :-   Book : Martindale    Page : 641   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Allergic conditions Oral 25 mg Tablet Dose: 25 mg at night increased to 25 mg twice daily if necessary; owing to its pronounced sedative effect it is preferably given at night but an alternative dose is 10 to 20 mg two or three times daily.
2 Short-term management of insomnia Oral 20 50 mg Tablet Given at night
3 Motion sickness Oral 20 mg Tablet Given at night before travelling followed by a similar dose the following morning if necessary. The teoclate is used similarly.
4 Motion sickness Oral 25 Tablet Given at night or 25 mg 1 to 2 hours before travelling.
5 Nausea and vomiting arising from causes such as labyrinthitis Oral 25 mg Tablet Given at night, this may be increased to 50 or 75 mg at night or to 25 mg two or three times daily if necessary to a maximum of 100 mg daily.
6 Severe vomiting in pregnancy Oral 25 mg Tablet Given at night, increased if necessary to a maximum of 100 mg.
7 rectal Suppository same as oral dose
8 IM 25 50 mg/ml Injection it may also be given by slow intravenous injection or injected into the tubing of a freely running infusion in a concentration of not more than 25 mg/ml, although it is usually diluted to 2.5 mg/ml. The rate of infusion should not exceed 25 mg/minute.

Ref :-  Book : Martindale    Page : 641   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Allergic conditions 2 Year 5 Year Oral 5 15 mg Tablet
2 Allergic conditions 5 Year 10 Year Oral 10 25 mg Tablet
3 Night sedation or premedication 2 Year 5 Year Oral 15 20 mg Tablet
4 Night sedation or premedication 5 Year 10 Year Oral 20 25 mg Tablet
5 Motion sickness 2 Year 5 Year Oral 5 mg Tablet
6 Motion sickness 5 Year 10 Year Oral 10 mg Tablet
7 Motion sickness 5 Year 10 Year Oral 12.5 mg Tablet
8 Nausea and vomiting arising from causes such as labyrinthitis 5 Year 10 Year Oral 12.5 37.5 mg Tablet
9 Nausea and vomiting 10 Year Oral Tablet
10 Allergic conditions or sedation 5 Year 10 Year IM 6.25 12.5 mg Injection

Ref :- Book : Martindale    Page : 641   Edition : 37  
►  Side Effect : CNS depression, Slight drowsiness to deep sleep, Lassitude, Dizziness, Incoordination, Headache, Psychomotor impairment, Dry mouth, Thickened respiratory-tract secretions, Blurred Vision, Urinary difficulty or retention, Constipation, Increased gastric reflux, Convulsion, Sweating, Myalgia, Paraesthesia, Extrapyramidal effects, Tremor, Sleep disturbances, Confusion, Tinnitus, Hair loss, Nausea, Vomiting, Diarrhoea, Epigastric pain, Hypersensitivity reactions, Bronchospasm, Angioedema, Anaphylaxis, Rashes, Depression, Bradycardia, Tachycardia, Transient minor increases in blood pressure and occasional hypotension, Parenteral administration of promethazine may cause various problems, ranging from pain and burning, to paralysis, thrombophlebitis, severe spasm of distal vessels, necrosis, and gangrene; such adverse effects are particularly seen after inadvertent intra-articular injection
Ref :-   Book : Martindale    Page : 611,640   Edition : 37.  

►  Drug Interaction : Drug interaction of Promethazine is with Alcohol, Barbiturates , Hypnotics, opioid analgesics, Anxiolytic sedatives, Antipsychotics, some antiepileptics , ,  Atropine
Ref :-   Book : Martindale    Page : 613,640   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Sedating antihistamines may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs)
Ref :-   Book : Martindale    Page : 613,640   Edition : 37.  


►  Contraindication : Urinary retention, Drowsiness is a major problem with the sedating antihistamines and those affected should not drive or operate machinery; alcohol should be avoided, Angle-closure glaucoma, prostatic hyperplasia, Pyloroduodenal obstruction, Renal impairment
Ref :-   Book : Martindale    Page : 612,640   Edition : 37.  
  ►  Mechanism of Action :   Inverse agonists that bind preferentially to the inactive conformation of the H1 receptor and shift the equilibrium toward the inactive receptor state.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 774   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Renal
Ref :-   Book : Martindale    Page : 640   Edition : 37.  

►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   14 hours.  
Ref :-   Book : Martindale    Page : 640   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours.  
Ref :-   Book : Martindale    Page : 640   Edition : 37.