Propafenone is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1515   Edition : 37  

  ►   Brandname : Cuxafenon, Jutanorm, Arythmol, Rythmol
  ►  Strength : Tablet/Capsule with 150 mg.  Tablet/Capsule with 225 mg.  Tablet/Capsule with 300 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 249   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1515   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Supraventricular and ventricular arrhythmias Oral 150 mg Tablet/Capsule t.i.d. Dose may be increased, if necessary, at intervals of 3 to 4 days up to a maximum of 300 mg three times daily. Reduced doses may be appropriate in patients weighing less than 70 kg and in the elderly

Ref :-  Book : Martindale    Page : 1515   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Bradycardia, heart block, Sinus arrest, Hypotension, Gastrointestinal intolerance, Dry mouth, Bitter or metallic taste in the mouth, Dizziness, Blurred Vision, Headache, Fatigue, Convulsions, Blood dyscrasias, Liver disorders, Lupus erythematosus, Rashes, impotence, Increased breathlessness, Worsening of asthma
Ref :-   Book : Martindale    Page : 1514   Edition : 37.  

►  Drug Interaction : Drug interaction of Propafenone is with HIV- protease inhibitors, Beta Blockers , ,  Rifampicin , Cimetidine , Fluoxetine , Quinidine , Desipramine, Digoxin , Theophylline , Venlafaxine , Warfarin
Ref :-   Book : Martindale    Page : 1514   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Propafenone is extensively metabolised by the cytochrome P450 enzyme system, mainly by the isoenzyme CYP2D6, although CYP1A2 and CYP3A4 are also involved. Interactions may therefore occur with other drugs that are metabolised by these enzymes. Plasma-propafenone concentrations may be reduced by enzyme inducers such as rifampicin; enzyme inhibitors, such as cimetidine, fluoxetine, quinidine, and HIV-protease inhibitors, may increase plasma-propafenone concentrations. Propafenone itself may alter the plasma concentrations of other drugs, including beta blockers, ciclosporin, desipramine, digoxin, theophylline, venlafaxine, and warfarin. The absorption of propafenone may be reduced by orlistat. There may be an increased risk of arrhythmias if propafenone is given with other antiarrhythmics or arrhythmogenic drugs.
Ref :-   Book : Martindale    Page : 1514   Edition : 37.  


►  Contraindication : Patients with uncontrolled heart failure, Conduction disturbances including heart block unless controlled by artificial pacing, cardiogenic shock (unless arrhythmia-induced), Conduction disturbances including heart block unless controlled by artificial pacing, cardiogenic shock (unless arrhythmia-induced), Severe bradycardia, or pronounced hypotension, Hepatic impairment, Renal impairment, It may alter the endocardial pacing threshold and adjustment may be necessary in patients with pacemakers, Propafenone has beta-blocking activity and may exacerbate obstructive airways disease; it should be used with great caution in such disorders and is contra-indicated in severe disease., Propafenone may aggravate myasthenia gravis and should be avoided in patients with this condition., Electrolyte disturbances should be corrected before beginning treatment
Ref :-   Book : Martindale    Page : 1514   Edition : 37.  
  ►  Mechanism of Action :   Propafenone is a class Ic antiarrhythmic with some negative inotropic and beta-adrenoceptor blocking activity
Ref :-   Book : Martindale    Page : 1515   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal
Ref :-   Book : Martindale    Page : 1515   Edition : 37.  

►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   7 hours.  
Ref :-   Book : Basic & Clinical pharmacology    Page : 242   Edition : 12.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA