Propafenone Hydrochloride is a Medicine belongs to Sodium channel blockers group whose information about Brand can be referenced from   Book : Martindale    Page : 1515   Edition : 37,

  ►   Brandname : Arythmol,Rythmol

  ►  Strength : Tablet with 150  Mg, Tablet with 225  Mg, Tablet with 300  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 249   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1515   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Supraventricular arrhythmias Oral 150 mg t.i.d.

Ref :-  Book : Martindale    Page : 1515   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : bradycardia, heart block, sinus arrest, heart failure, hypotension, Gastrointestinal intolerance, dry mouth, bitter taste, matallic taste, Dizziness, Blurred Vision, headache, fatigue, convulsion, blood dyscrasias, liver disorders, lupus erythematosus, Skin rashes, impotence, worsening of asthma, increased breathlessness,
Ref :-   Book : Martindale    Page : 1514   Edition : 37,

►  Drug Interaction : Drug interaction of Propafenone Hydrochloride is with Rifampicin , Cimetidine , Fluoxetine , Quinidine , Pioglitazone Hydrochloride , Mivacurium Chloride , Cyclosporine , desipramine, Digoxin , Theophylline , Venlafaxine , Warfarin ,
Ref :-   Book : Martindale    Page : 1514   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Propafenone is extensively metabolised by the cytochrome P450 enzyme system, mainly by the isoenzymeCYP2D6, although CYP1A2 and CYP3A4 are also involved. Interactions may therefore occur with other drugs that are metabolised by these enzymes. Plasma-propafenone concentrations may be reduced by enzyme inducers such as rifampicin; enzyme inhibitors, such as cimetidine, fluoxetine, quinidine, and HIV-protease inhibitors, may increase plasma-propafenone concentrations. Propafenone itself may alter the plasma concentrations of other drugs, including beta blockers, ciclosporin, desipramine, digoxin, theophylline, venlafaxine, and warfarin. The absorption of propafenone may be reduced by orlistat. There may be an increased risk of arrhythmias if propafenone is given with other antiarrhythmics or arrhythmogenic drugs,
Ref :-   Book : Martindale    Page : 1514   Edition : 37,


►  Contraindication : cardiogenic shock, atrial flutter, atrial fibrillation,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 419   Edition : 3,
  ►  Mechanism of Action :   Marked block of voltage-gated Na+ channels in ventricular myocytes (decreases phase 0 Upstroke velocity).,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 419   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Renal,
Ref :-   Book : Martindale    Page : 1515   Edition : 37,


►    Plasma Half-life :
  Min value :-   2 hours,    Max value :-   10 hours,
Ref :-   Book : Martindale    Page : 1515   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,