Propantheline is a Medicine belongs to anticholinergic group whose information about Brand can be referenced from   Book : Martindale    Page : 1919   Edition : 37,

  ►   Brandname : ProBanthine

  ►  Strength : Tablet with 7.5  mg, Tablet with 15  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 127   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1919   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gastrointestinal spasm Oral 15 mg Tablet t.i.d. 30 to 60 minutes before meals.
2 Gastrointestinal spasm Oral 30 mg Tablet h.s.
3 Gastrointestinal spasm Oral 7.5 mg Tablet t.i.d.
4 Peptic ulcer Oral 15 mg Tablet t.i.d. 30 to 60 minutes before meals.
5 Peptic ulcer Oral 30 mg Tablet h.s.
6 Peptic ulcer Oral 7.5 mg Tablet t.i.d.

Ref :-  Book : Martindale    Page : 1919   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Gastrointestinal spasm 1 Month 12 Year Oral 300 micrograms/kg Tablet t.i.d/q.i.d

Ref :- Book : Martindale    Page : 1919   Edition : 37,
►  Side Effect : Dryness of the mouth, difficulty in talking, difficulty in swallowing, thirst, oesophageal ulceration, reduced bronchial secretions, mydriasis, cycloplegia, photophobia, flushing, Dryness, dryness of the skin, tachycardia, palpitations, arrhythmia, difficulty in micturition, constipation, impotence,
Ref :-   Book : Martindale    Page : 1343,1919   Edition : 37,

►  Drug Interaction : Drug interaction of Propantheline is with Amantadine , Atropine , Cocaine , Phenothiazine, , , Cisapride , Domperidone , Acarbose , Glimepiride ,
Ref :-   Book : Martindale    Page : 1343,1919   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Antimuscarinic activity may be enhanced by use of other drugs having antimuscarinic properties, such as atropine, amantadine, some antihistamines, phenothiazine antipsychotics, and tricyclic antidepressants. Inhibition of drug-metabolising enzymes by MAOIs may possibly enhance the effects of antimuscarinics. The reduction in gastric motility caused by antimuscarinics may affect the absorption of other drugs. Antimuscarinics may also antagonise the gastrointestinal effects of cisapride, domperidone, and metoclopramide. Antimuscarinics and parasympathomimetics may counteract each others effects. ,
Ref :-   Book : Martindale    Page : 1343   Edition : 37,


►  Contraindication : prostatic enlargement, urinary retention, narrow-angle glaucoma, paralytic ileus, myasthenia gravis, Fever, diarrhoea, heart failure, , Parkinson’s disease,
Ref :-   Book : Martindale    Page : 1343   Edition : 37, Martindale    Page : 1343,1919   Edition : 37,
  ►  Mechanism of Action :   It is a quaternary ammonium antimuscarinic that prevent the effects of ACh by blocking its binding to muscarinic receptors on effector cells & exhibit a greater degree of nicotinic blocking activity and therefore are more likely to interfere with ganglionic or neuromuscular transmission.,
Ref :-   Book : Goodman    Page : 225   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1919   Edition : 37,


►    Plasma Half-life :
  Min value :-   2 hours,    Max value :-   3 hours,
Ref :-   Book : Martindale    Page : 1919   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,